| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
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| Other Sizes |
| Targets |
Triethyl phosphate does not have a specific biological target as it is an industrial chemical rather than a drug. Its mechanism of action as a flame retardant involves the release of phosphorus-containing radicals that interfere with the combustion process. As a plasticizer, it works by embedding between polymer chains, increasing flexibility. Its toxicological effects are primarily due to its interaction with biological systems.
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|---|---|
| ln Vitro |
In vitro, triethyl phosphate has been studied for its toxicity and potential neurotoxic effects. It can be metabolized by liver microsomes to various metabolites. In cell-based assays, it has been shown to affect cell viability and function at high concentrations. However, detailed in vitro pharmacological or toxicological data are limited.
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| ln Vivo |
In vivo, triethyl phosphate is absorbed through the skin and gastrointestinal tract. It has been studied in animal models for its toxicological effects, including neurotoxicity and reproductive toxicity. The compound is a known toxicant, and exposure should be minimized. It is not used as a therapeutic agent.
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| Enzyme Assay |
In vitro enzyme or receptor binding (non-cell) assays for triethyl phosphate are not typically performed, as it is not a drug. However, its metabolism can be studied using liver microsomes or purified cytochrome P450 enzymes. The compound's ability to inhibit enzymes, such as esterases, can also be assessed using biochemical assays.
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| Cell Assay |
In vitro cell-based assays for triethyl phosphate are performed using various cell lines to study its cytotoxic and potentially neurotoxic effects. Cells are treated with the compound, and cell viability, proliferation, and apoptosis are assessed. The compound's effects on gene expression and signaling pathways can also be analyzed.
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| Animal Protocol |
In vivo animal experiments for triethyl phosphate are conducted using rodent models to study its toxicological effects. The compound is administered orally or dermally. Neurobehavioral tests, reproductive toxicity assessments, and histopathological examinations are performed. These studies are used to evaluate the compound's safety for its intended industrial applications.
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| ADME/Pharmacokinetics |
Pharmacokinetic (PK) properties of triethyl phosphate indicate that it is absorbed through the skin and gastrointestinal tract. The compound has a molecular weight of 182.15 and a molecular formula of C6H15O4P. It is a colorless liquid with a boiling point of 215°C. It is metabolized in the liver and excreted renally.
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| Toxicity/Toxicokinetics |
Toxicity Data
LCLo (Rats) > 8,817 mg/m³/4h Non-human Toxicity Values LD50 (Rats, Oral) 1.6 g/kg LC50 (Rats, Inhalation) > 8,817 mg/cu m/4 hours LD50 (Rats, Intraperitoneal) 0.8 g/kg LD50 (Guinea Pig Skin) > 21.4 g/kg For more complete non-human toxicity data for triethyl phosphate (9 items), please visit the HSDB records page. Toxicology (toxicology) data for triethyl phosphate indicate that it is toxic. It is harmful if swallowed, inhaled, or absorbed through the skin. It can cause irritation to the eyes, skin, and respiratory tract. It may also cause damage to the nervous system and other organs. The compound should be handled with appropriate protective equipment. |
| References |
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| Additional Infomation |
Triethyl phosphate is a colorless, corrosive, and flammable liquid. It dissolves slowly in water and sinks to the bottom. It is highly irritating to skin, eyes, and mucous membranes. Triethyl phosphate is a trialkyl phosphate ester, a triethyl phosphate derivative. Its structure is similar to ethanol. Ethyl phosphate is formed by the reaction of diethyl phosphate with water; ethanol is a byproduct.
Other information: Triethyl phosphate is an industrial chemical used as a plasticizer, solvent, and flame retardant. It is also known as TEP. The compound is used in the production of plastics, resins, and coatings. Its CAS number is 78-40-0. |
| Molecular Formula |
C6H15O4P
|
|---|---|
| Molecular Weight |
182.16
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| Exact Mass |
182.07
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| CAS # |
78-40-0
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| PubChem CID |
6535
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| Appearance |
Liquid
Colorless, high-boiling liquid |
| Density |
1.1±0.1 g/cm3
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| Boiling Point |
219.3±8.0 °C at 760 mmHg
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| Melting Point |
-56 °C
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| Flash Point |
115.6±0.0 °C
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| Vapour Pressure |
0.2±0.4 mmHg at 25°C
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| Index of Refraction |
1.406
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| LogP |
1.08
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
11
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| Complexity |
113
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| Defined Atom Stereocenter Count |
0
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| SMILES |
P(=O)(OC([H])([H])C([H])([H])[H])(OC([H])([H])C([H])([H])[H])OC([H])([H])C([H])([H])[H]
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| InChi Key |
DQWPFSLDHJDLRL-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H15O4P/c1-4-8-11(7,9-5-2)10-6-3/h4-6H2,1-3H3
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| Chemical Name |
triethyl phosphate
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| Synonyms |
NSC-2677; NSC 2677; Triethyl phosphate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~200 mg/mL (~1098.0 mM; with ultrasonication)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.4897 mL | 27.4484 mL | 54.8968 mL | |
| 5 mM | 1.0979 mL | 5.4897 mL | 10.9794 mL | |
| 10 mM | 0.5490 mL | 2.7448 mL | 5.4897 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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