| Targets |
Triethoxycaprylylsilane does not have a specific biological target as it is an industrial chemical used in cosmetics. Its primary function is as a surface modifier, improving the wetting and adhesion properties of cosmetic formulations. It forms a covalent bond with hydroxyl groups on surfaces, such as skin and hair, creating a hydrophobic layer that enhances water resistance and product durability.
|
|---|---|
| ln Vitro |
In vitro, triethoxycaprylylsilane is not typically studied for biological activity. Its effects are evaluated in cosmetic formulations, where it improves the spreadability, adhesion, and water resistance of products. The compound is generally considered safe for use in cosmetics at the concentrations used.
|
| ln Vivo |
In vivo, triethoxycaprylylsilane is used in cosmetic products applied to the skin and hair. It is not absorbed systemically to a significant extent and is considered safe for topical use. The compound is used in sunscreens, foundations, and other personal care products.
|
| Enzyme Assay |
In vitro enzyme or receptor binding (non-cell) assays are not applicable for triethoxycaprylylsilane, as it is not a drug. Its properties as a surface modifier can be assessed using physical chemistry methods, such as contact angle measurements and surface energy analysis.
|
| Cell Assay |
In vitro cell-based assays are not applicable for triethoxycaprylylsilane, as it is not a biologically active compound. Its use is limited to cosmetic formulations, and it is not tested in cell-based assays for biological activity.
|
| Animal Protocol |
In vivo animal experiments are not applicable for triethoxycaprylylsilane, as it is not a therapeutic agent. Its safety for use in cosmetics has been evaluated in toxicological studies, and it is considered safe for topical use at the concentrations used.
|
| ADME/Pharmacokinetics |
Pharmacokinetic (PK) properties are not applicable for triethoxycaprylylsilane, as it is not a drug. It is used in cosmetic products applied to the skin and is not absorbed systemically to a significant extent. The compound has a molecular weight of 346.55 and a molecular formula of C14H32O3Si.
|
| Toxicity/Toxicokinetics |
Toxicology (toxicology) data for triethoxycaprylylsilane indicate that it is considered safe for use in cosmetics. It is not a skin sensitizer or irritant at the concentrations used in cosmetic formulations. The compound should be handled with appropriate safety precautions, and it is for external use only.
|
| Additional Infomation |
Octyltriethoxysilane is an organosilicon compound.
See also: Oleth-30 (note moved to). Other information: Triethoxycaprylylsilane is a surface modifier used in cosmetics and personal care products. It is also known as Silane, triethoxyoctyl. The compound is used in sunscreens, foundations, and other cosmetic products. Its CAS number is 2943-75-1. |
| Molecular Formula |
C14H32O3SI
|
|---|---|
| Molecular Weight |
276.4876
|
| Exact Mass |
276.212
|
| CAS # |
2943-75-1
|
| Related CAS # |
156327-81-0
|
| PubChem CID |
76262
|
| Appearance |
Colorless to light yellow liquid（Density：0.88 g/cm3）
|
| Density |
0.9±0.1 g/cm3
|
| Boiling Point |
224.4±8.0 °C at 760 mmHg
|
| Melting Point |
-40ºC
|
| Flash Point |
101.3±21.3 °C
|
| Vapour Pressure |
0.1±0.4 mmHg at 25°C
|
| Index of Refraction |
1.428
|
| LogP |
5.45
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
13
|
| Heavy Atom Count |
18
|
| Complexity |
159
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
[Si](C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])(OC([H])([H])C([H])([H])[H])(OC([H])([H])C([H])([H])[H])OC([H])([H])C([H])([H])[H]
|
| InChi Key |
MSRJTTSHWYDFIU-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C14H32O3Si/c1-5-9-10-11-12-13-14-18(15-6-2,16-7-3)17-8-4/h5-14H2,1-4H3
|
| Chemical Name |
triethoxy(octyl)silane
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6168 mL | 18.0838 mL | 36.1677 mL | |
| 5 mM | 0.7234 mL | 3.6168 mL | 7.2335 mL | |
| 10 mM | 0.3617 mL | 1.8084 mL | 3.6168 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
