| Size | Price | Stock | Qty |
|---|---|---|---|
| 10mg |
|
||
| 50mg |
|
||
| 100mg |
|
||
| Other Sizes |
| Targets |
TP748 does not have a defined biological target as it is a synthetic intermediate rather than a drug molecule. Its role in research is as a chemical building block for the construction of fully synthetic tetracycline antibiotics. The compound itself is not designed to interact with biological receptors or enzymes. Instead, it serves as a scaffold that enables the synthesis of tetracycline derivatives that target the bacterial ribosome, the classic target of tetracycline antibiotics. The pharmacological activity of TP748 is realized only after it is incorporated into more complex tetracycline structures through subsequent chemical synthesis steps.
|
|---|---|
| ln Vitro |
Enantioenriched (S)-allylamine 3, a crucial intermediary in the whole synthesis of tetracycline, may now be produced with a reliable, economical, and high-yield approach that has been established [1].
TP748 itself does not possess intrinsic biological activity as it is a synthetic intermediate rather than a pharmacologically active compound. Its in vitro activity is related to its utility as a chemical reagent in organic synthesis reactions, such as coupling, functionalization, and cyclization steps, to produce fully synthetic tetracycline antibiotics. The compound's chemical reactivity, rather than its biological activity, is the focus of in vitro studies. Researchers use TP748 to construct tetracycline scaffolds that are then evaluated for antibacterial activity against various bacterial strains. |
| ln Vivo |
In vivo activity is not applicable to TP748, as it is a chemical intermediate used in organic synthesis rather than a pharmacologically active drug candidate. The compound is not intended for administration to animals or humans, and its biological effects in vivo have not been studied. Any in vivo activity would be associated with the final tetracycline antibiotics synthesized from TP748, not with the intermediate itself. TP748 is strictly a research chemical used for the synthesis of antibiotic compounds, and it does not possess therapeutic properties on its own.
|
| Enzyme Assay |
In vitro enzyme/receptor binding experiments are not applicable to TP748 because it is a synthetic intermediate rather than a biologically active compound. The compound is not designed to bind to enzymes or receptors. Instead, its characterization involves chemical analysis methods such as NMR spectroscopy, HPLC, and mass spectrometry to confirm its structure and purity. Researchers use these analytical techniques to verify the identity and quality of TP748 before using it in chemical synthesis. The compound's chemical properties, such as solubility and reactivity, are assessed in organic solvents rather than in biological assay systems.
|
| Cell Assay |
In vitro cellular experiments are not performed with TP748, as it is a chemical intermediate used in organic synthesis rather than a biologically active compound. The compound is not intended for cell-based assays, and its effects on cellular systems have not been studied. TP748 is used exclusively as a building block in the chemical synthesis of tetracycline antibiotics. Researchers handling TP748 follow standard chemical safety protocols for organic synthesis, including the use of appropriate personal protective equipment and working in a fume hood. The compound is stored under conditions that maintain its chemical stability.
|
| Animal Protocol |
In vivo animal experiments are not applicable to TP748, as it is a chemical intermediate rather than a pharmacologically active compound. The compound is not administered to animals, and its biological effects have not been studied in vivo. Any animal studies would be conducted with the final tetracycline antibiotics that are synthesized from TP748, not with the intermediate itself. TP748 is strictly a research chemical used for the synthesis of antibiotic compounds in the laboratory, and it does not have therapeutic applications that would warrant in vivo testing.
|
| ADME/Pharmacokinetics |
Pharmacokinetic properties are not applicable to TP748, as it is a chemical intermediate used in organic synthesis rather than a pharmacologically active drug candidate. The compound is not intended for administration to animals or humans, and its absorption, distribution, metabolism, and excretion have not been studied. TP748 is used exclusively as a building block in the chemical synthesis of tetracycline antibiotics. Its physicochemical properties, such as molecular weight (258.32) and solubility, are relevant to its handling in chemical reactions rather than to biological systems.
|
| Toxicity/Toxicokinetics |
Toxicological data for TP748 are limited, as the compound is a chemical intermediate rather than a drug candidate. Standard safety precautions for handling organic chemicals apply, including the use of personal protective equipment and working in a well-ventilated area. The compound is not intended for human consumption, and its toxicity profile has not been extensively characterized. Researchers handling TP748 should refer to the material safety data sheet (MSDS) for specific hazard information. The compound is typically stored at room temperature in a dry, well-ventilated area away from incompatible materials.
|
| References |
[1]. Wu-Yan Zhang, et al. Process Research and Development of TP-808: A Key Intermediate for the Manufacture of Synthetic Tetracyclines. Process Res. Dev. 2017, 21, 3, 377-386.
|
| Additional Infomation |
TP748 is a research chemical that has not entered clinical trials or received regulatory approval for therapeutic use. It is a key synthetic intermediate for the preparation of fully synthetic tetracycline antibiotics, a class of compounds designed to overcome bacterial resistance. The compound is exclusively used in medicinal chemistry research for the synthesis of novel antibiotic agents. Its value lies in its ability to serve as a versatile scaffold for constructing advanced tetracycline frameworks. Further pharmacological development would involve the synthesis and evaluation of tetracycline derivatives derived from TP748, not the intermediate itself.
|
| Molecular Formula |
C₁₅H₁₈N₂O₂;
|
|---|---|
| Molecular Weight |
258.32;
|
| Exact Mass |
258.136
|
| CAS # |
951698-15-0
|
| PubChem CID |
17756552
|
| Appearance |
White to off-white solid powder
|
| Density |
1.1±0.1 g/cm3
|
| Boiling Point |
367.3±42.0 °C at 760 mmHg
|
| Flash Point |
176.0±27.9 °C
|
| Vapour Pressure |
0.0±0.8 mmHg at 25°C
|
| Index of Refraction |
1.547
|
| LogP |
2.95
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
6
|
| Heavy Atom Count |
19
|
| Complexity |
277
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
O1C(=CC(=N1)OCC1C=CC=CC=1)[C@H](C=C)N(C)C
|
| InChi Key |
NMTKAGBTRNHHDC-ZDUSSCGKSA-N
|
| InChi Code |
InChI=1S/C15H18N2O2/c1-4-13(17(2)3)14-10-15(16-19-14)18-11-12-8-6-5-7-9-12/h4-10,13H,1,11H2,2-3H3/t13-/m0/s1
|
| Chemical Name |
(1S)-N,N-dimethyl-1-(3-phenylmethoxy-1,2-oxazol-5-yl)prop-2-en-1-amine
|
| Synonyms |
TP-748
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
