| Size | Price | Stock | Qty |
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| 10mg |
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| 25mg |
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| 100mg |
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| 250mg |
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| 500mg | |||
| Other Sizes |
| Targets |
The primary target of Tiadinil is the plant's defense system. It acts as a plant activator of systemic acquired resistance (SAR). By inducing SAR, it enhances the plant's ability to resist pathogen attack. It has also been found to be effective in the treatment of type 2 diabetes mellitus and has been shown to improve insulin sensitivity and glucose uptake. It exhibits anti-inflammatory, antioxidant, and antidiabetic activity.
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| ln Vitro |
In vitro, Tiadinil exhibits potent biological activity, including anti-inflammatory, antioxidant, and antidiabetic activity. Its mechanism of action may involve the modulation of inflammatory pathways and improvement of insulin sensitivity. These properties make it a compound of interest not only for agricultural applications but also for potential therapeutic uses.
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| ln Vivo |
In vivo, Tiadinil is used as a systemic fungicide in agriculture. It induces systemic acquired resistance in plants, protecting them from various pathogens. Its effects on insulin sensitivity and glucose uptake suggest potential for treating metabolic disorders. However, its primary use is as a plant protection product.
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| Enzyme Assay |
For fungicidal activity assays, Tiadinil is tested against various plant pathogenic fungi using agar dilution or disk diffusion methods. The compound is dissolved in a suitable solvent and incorporated into growth media. Fungal growth is measured, and EC50 values are calculated. For plant SAR assays, plants are treated with Tiadinil and then challenged with a pathogen. Disease severity is assessed.
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| Cell Assay |
For cellular studies, cell lines relevant to diabetes or inflammation are cultured. Tiadinil is dissolved in DMSO and diluted in culture medium. Cells are treated with the compound, and parameters such as glucose uptake, insulin signaling (e.g., Akt phosphorylation), and inflammatory cytokine production are measured. For mechanistic studies, signaling pathways are analyzed by Western blot.
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| Animal Protocol |
For in vivo efficacy studies in plants, Tiadinil is applied as a foliar spray or drench. Disease incidence and severity are monitored. For animal models of diabetes, the compound would be administered orally, and blood glucose levels, insulin sensitivity, and other metabolic parameters would be measured.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for Tiadinil in animals are not extensively reported. As a small molecule, it is expected to be absorbed and metabolized. Its primary use is as an agricultural chemical, and its PK in mammals would be relevant for any potential therapeutic development.
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| Toxicity/Toxicokinetics |
Toxicological data for Tiadinil indicate that it is of low toxicity to mammals, with a rat acute oral LD50 > 2000 mg/kg. It may cause some eye and skin irritation but is not a sensitizer. As with all chemicals, appropriate safety precautions should be taken during handling.
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| References |
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| Additional Infomation |
Thiamethoxam is a monocarboxylic acid amide, formed by the condensation of the carboxyl group of 4-methyl-1,2,3-thiadiazole-5-carboxylic acid with the amino group of 3-chloro-4-methylaniline. It is a fungicide primarily used to control fungal diseases in rice. It is an antifungal pesticide. Thiamethoxam belongs to the categories of monocarboxylic acid amides, monochlorobenzene compounds, thiadiazole compounds, organosulfur compounds, and aniline fungicides.
Tiadinil (CAS 223580-51-6) is a systemic fungicide and plant activator. It induces systemic acquired resistance in plants. It has the molecular formula C₁₁H₁₀ClN₃OS and a molecular weight of 267.73. It exhibits anti-inflammatory, antioxidant, and antidiabetic activity. It is a research tool for studying plant defense and metabolic disorders. |
| Molecular Formula |
C11H10N3OSCL
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|---|---|
| Molecular Weight |
267.7346
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| Exact Mass |
267.023
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| CAS # |
223580-51-6
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| PubChem CID |
2804318
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| Appearance |
Yellow to brown solid powder
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| Density |
1.4±0.1 g/cm3
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| Index of Refraction |
1.663
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| LogP |
3.25
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
17
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| Complexity |
292
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C(C1=C(C)N=NS1)NC2=CC=C(C)C(Cl)=C2
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| InChi Key |
VJQYLJSMBWXGDV-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C11H10ClN3OS/c1-6-3-4-8(5-9(6)12)13-11(16)10-7(2)14-15-17-10/h3-5H,1-2H3,(H,13,16)
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| Chemical Name |
N-(3-chloro-4-methylphenyl)-4-methylthiadiazole-5-carboxamide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~466.89 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7351 mL | 18.6755 mL | 37.3511 mL | |
| 5 mM | 0.7470 mL | 3.7351 mL | 7.4702 mL | |
| 10 mM | 0.3735 mL | 1.8676 mL | 3.7351 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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