| Size | Price | Stock | Qty |
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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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| Other Sizes |
| Targets |
Tetrasul targets mites and aphids, functioning as an acaricide and insecticide. It inhibits Tetranychus urticae (two-spotted spider mites) and aphids on hops. As a chlorinated diphenyl sulfide, its mechanism involves disruption of the nervous system or other essential physiological processes in target pests. The compound has also been investigated for its potential use in treating rosacea.
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| ln Vitro |
In vitro, tetrasul demonstrates acaricidal activity against Tetranychus urticae and other mite species. Its activity is assessed by contact toxicity assays or by measuring inhibition of mite reproduction. The compound's efficacy against aphids is evaluated in insecticidal bioassays. Its potency is compared to that of other acaricides and insecticides.
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| ln Vivo |
In vivo, tetrasul is used as an acaricide for the control of phytophagous mites and aphids in agricultural and horticultural crops. It is applied as a foliar spray or as a soil treatment. The compound's effectiveness against two-spotted spider mites and aphids on hops has been demonstrated in field studies. Tetrasul has also been used in clinical trials investigating the treatment of erythematous rosacea.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays for tetrasul are not typically performed as the compound is an acaricide rather than a pharmacologically active compound. Its mechanism of action in target pests involves neurotoxic or physiological disruption. Binding studies to pest-specific targets may be conducted for mechanistic research.
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| Cell Assay |
In vitro cell-based assays for tetrasul use insect or mite cell lines to assess cytotoxicity and mechanism of action. Cells are treated with serial dilutions of the compound, and cell viability is measured using MTT or other assays. The compound's effects on cellular physiology, including ion channel function or enzyme activity, may be evaluated.
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| Animal Protocol |
In vivo animal models for tetrasul include agricultural field trials and laboratory studies using infested plants. The compound is applied to plants infested with mites or aphids, and efficacy is evaluated by counting pest populations before and after treatment. Dose-response studies establish the effective concentration for pest control. Clinical trials for rosacea involve human subjects with erythematous rosacea.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of tetrasul are not well characterized as the compound is an agricultural pesticide. Its environmental fate, including persistence in soil and plants, degradation products, and bioaccumulation potential, is studied for regulatory purposes. The compound's absorption, distribution, metabolism, and excretion in mammals may be evaluated for toxicological risk assessment.
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| Toxicity/Toxicokinetics |
Toxicity data for tetrasul are available from regulatory toxicology studies for pesticide registration. The compound is an organochlorine compound and may have environmental persistence concerns. Acute toxicity to mammals is relatively low, but chronic exposure may have health effects. The compound is toxic to aquatic organisms. Occupational exposure may cause skin and eye irritation.
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| References | |
| Additional Infomation |
Tetrasul is an organochlorine compound. Tetrasul has been used in trials investigating the treatment of erythematous (type I) rosacea.
Tetrasul is an acaricide used for the control of phytophagous mites and aphids in agriculture. It is also known as tetradisul in Canada and diphenyl sulphide in Japan. The compound has been studied for the treatment of erythematous rosacea. Its chemical name is 1,2,4-trichloro-5-(4-chlorophenyl)sulfanylbenzene. Regulatory status varies by country, with some jurisdictions restricting its use due to environmental concerns. |
| Molecular Formula |
C12H6CL4S
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|---|---|
| Molecular Weight |
324.04
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| Exact Mass |
321.894
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| CAS # |
2227-13-6
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| PubChem CID |
16685
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.6±0.1 g/cm3
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| Boiling Point |
408.1±45.0 °C at 760 mmHg
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| Flash Point |
185.9±25.9 °C
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| Vapour Pressure |
0.0±0.9 mmHg at 25°C
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| Index of Refraction |
1.679
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| LogP |
7.27
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
17
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| Complexity |
243
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C1=C(C=CC(=C1)SC2=C(C=C(C(=C2)Cl)Cl)Cl)Cl
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| InChi Key |
QUWSDLYBOVGOCW-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C12H6Cl4S/c13-7-1-3-8(4-2-7)17-12-6-10(15)9(14)5-11(12)16/h1-6H
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| Chemical Name |
Benzene, 1,2,4-trichloro-5-((4-chlorophenyl)thio)-
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| Synonyms |
V 101 V-101 TetrasulV101
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0860 mL | 15.4302 mL | 30.8604 mL | |
| 5 mM | 0.6172 mL | 3.0860 mL | 6.1721 mL | |
| 10 mM | 0.3086 mL | 1.5430 mL | 3.0860 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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