| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
|
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| Other Sizes |
| Targets |
Sulfacarbamide targets multiple pathways. It has antibacterial activity by inhibiting dihydropteroate synthase (DHPS). It also has hypoglycemic activity, acting on the autonomic nervous system. It may also target potassium channels.
|
|---|---|
| ln Vitro |
In vitro, sulfacarbamide exhibits antibacterial activity. It is a blood sugar-lowering drug. It also acts on the vegetative nervous system. Its multiple activities make it a compound of interest in research.
|
| ln Vivo |
In vivo, sulfacarbamide is used as an antibacterial agent. It also has hypoglycemic effects. However, its clinical use is limited.
|
| Enzyme Assay |
In vitro enzyme/receptor binding assays for sulfacarbamide typically involve evaluating its inhibitory activity against DHPS or its binding to potassium channels. The enzyme is incubated with varying concentrations of sulfacarbamide and its substrate, and the inhibition of enzyme activity is measured.
|
| Cell Assay |
For in vitro cell-based assays, sulfacarbamide is dissolved in DMSO and applied to cultured cells at concentrations ranging from 1-100 µM. The effects on cell viability, glucose metabolism, and channel activity are assessed.
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| Animal Protocol |
In vivo animal studies for sulfacarbamide are typically conducted in rodent models of diabetes or bacterial infection. Sulfacarbamide is administered orally at doses ranging from 10-100 mg/kg. Efficacy is evaluated by measuring blood glucose levels or bacterial load.
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| ADME/Pharmacokinetics |
Sulfacarbamide has a molecular formula of C₇H₉N₃O₃S and a molecular weight of 215.23 g/mol. It is a white solid. It is soluble in DMSO and is typically stored as a powder at -20°C.
|
| Toxicity/Toxicokinetics |
Sulfacarbamide is considered to have a manageable toxicity profile. As a sulfonamide, it may cause hypersensitivity reactions and other side effects. Appropriate safety precautions should be followed when handling the compound.
|
| Additional Infomation |
Sulfamide is a sulfonamide, belonging to the benzene family of compounds.
Sulfacarbamide is a sulfonamide with blood sugar-lowering and antibacterial properties. It is also known as sulfanilylurea. Sulfacarbamide is not approved for clinical use in many countries and is intended for research purposes only. It is supplied by various research chemical suppliers for non-human use. |
| Molecular Formula |
C7H9N3O3S
|
|---|---|
| Molecular Weight |
215.23
|
| Exact Mass |
215.036
|
| CAS # |
547-44-4
|
| Related CAS # |
4675-90-5 (Na); 547-44-4;
|
| PubChem CID |
11033
|
| Appearance |
White to off-white solid powder
|
| Density |
1.504g/cm3
|
| Index of Refraction |
1.634
|
| LogP |
2.379
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
14
|
| Complexity |
301
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O=S(C1=CC=C(N)C=C1)(NC(N)=O)=O
|
| InChi Key |
WVAKABMNNSMCDK-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C7H9N3O3S/c8-5-1-3-6(4-2-5)14(12,13)10-7(9)11/h1-4H,8H2,(H3,9,10,11)
|
| Chemical Name |
(4-aminophenyl)sulfonylurea
|
| Synonyms |
Sulfanilylurea; Uramid; Sulfacarbamide
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ≥ 28 mg/mL (~130.09 mM)
H2O : ~5 mg/mL (~23.23 mM) |
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.6462 mL | 23.2310 mL | 46.4619 mL | |
| 5 mM | 0.9292 mL | 4.6462 mL | 9.2924 mL | |
| 10 mM | 0.4646 mL | 2.3231 mL | 4.6462 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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