| Size | Price | Stock | Qty |
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| 5g |
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| Other Sizes |
| Targets |
Strombine does not have a specific pharmacological target. It is an endogenous metabolite produced by a dehydrogenase. As an imino acid, it is involved in anaerobic metabolism in marine invertebrates and some fish species, where it serves as an alternative energy source during periods of low oxygen availability. Its biological role is primarily metabolic rather than as a drug targeting a specific receptor or enzyme.
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| ln Vitro |
In vitro, Strombine is characterized as an imino acid produced by a dehydrogenase. It is a compound present in the hemolymph that is capable of cryoprotection. Specific pharmacological activity data, such as IC50 values against specific targets, are not applicable as it is not a drug candidate. Its activity is studied in the context of comparative biochemistry and metabolism.
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| ln Vivo |
In vivo, Strombine functions as an endogenous metabolite involved in anaerobic metabolism in invertebrates and fish. It serves as an alternative energy source during periods of low oxygen availability. It is not used as a therapeutic agent in humans or animals.
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| Enzyme Assay |
A cell-free assay for Strombine is not applicable as it is not an enzyme inhibitor or receptor ligand. Its properties as an amino acid derivative can be characterized by standard biochemical methods. It can be used as a substrate or marker in enzymatic assays studying dehydrogenase activity.
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| Cell Assay |
Cellular experiments with Strombine are not typical, as it is not a pharmacologically active compound. Its study is primarily in the context of comparative biochemistry and metabolism in marine organisms.
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| Animal Protocol |
In vivo animal experiments for Strombine are not applicable, as it is an endogenous metabolite and not a therapeutic drug.
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| ADME/Pharmacokinetics |
Strombine has a molecular formula of C5H9NO4 and a molecular weight of 147.13. It is a solid powder with a purity of ≥95%. The compound should be sealed in dry storage. Pharmacokinetic properties are not applicable as it is not a therapeutic drug.
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| Toxicity/Toxicokinetics |
Toxicity data for Strombine are not provided in the available sources. As an endogenous amino acid derivative, it is not considered toxic at physiological concentrations. It is not used as a therapeutic drug.
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| Additional Infomation |
N-(carboxymethyl)-L-alanine is a derivative of L-alanine, in which a hydrogen atom on the amino group is replaced by a carboxymethyl group. It is a marine metabolite that attracts fish. It is a metabolite found in both marine and animal organisms. It is an aminodicarboxylic acid and also a derivative of L-alanine. Functionally, it is related to iminodiacetic acid.
Strombine (CAS: 56857-47-7) is a naturally occurring amino acid derivative and imino acid. It is also known as N-(carboxymethyl)-L-alanine, 2-methyliminodiacetic acid, and (S)-2-((carboxymethyl)amino)propanoic acid. The compound is involved in anaerobic metabolism and has cryoprotective properties. Its molecular formula is C5H9NO4 and its molecular weight is 147.13. It is not a therapeutic drug and is strictly for research purposes. |
| Molecular Formula |
C5H9NO4
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|---|---|
| Molecular Weight |
147.1293
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| Exact Mass |
147.053
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| CAS # |
56857-47-7
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| PubChem CID |
440119
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| Appearance |
White to off-white solid powder
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| LogP |
-2.9
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
10
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| Complexity |
145
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| Defined Atom Stereocenter Count |
1
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| SMILES |
O([H])C([C@]([H])(C([H])([H])[H])N([H])C([H])([H])C(=O)O[H])=O
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| InChi Key |
XYUPSBLFPTWJLC-VKHMYHEASA-N
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| InChi Code |
InChI=1S/C5H9NO4/c1-3(5(9)10)6-2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m0/s1
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| Chemical Name |
(2S)-2-(carboxymethylamino)propanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~25 mg/mL (~169.92 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.7967 mL | 33.9836 mL | 67.9671 mL | |
| 5 mM | 1.3593 mL | 6.7967 mL | 13.5934 mL | |
| 10 mM | 0.6797 mL | 3.3984 mL | 6.7967 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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