| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
Solvent Yellow 93 does not have a specific biological target, as it is primarily used as a dye and colorant. Its primary function is to provide color in industrial and consumer products. In biological research, dyes like Solvent Yellow 93 are sometimes used as tools for staining or labeling, but they are not designed to interact with a specific receptor or enzyme. The compound's interactions with biological systems are generally non-specific, and its primary relevance to biology is in the context of toxicology and environmental impact.
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| ln Vitro |
In vitro, Solvent Yellow 93 is not typically used in biological activity assays due to its role as a dye. However, it may be used in certain staining or labeling protocols in research settings. The compound's bright yellow color and solubility in organic solvents make it suitable for use in histological and cytological applications. It can also be used as a model compound in studies of dye degradation or environmental fate. Its ability to blend with fluorescent dyes for color mixing suggests potential applications in fluorescence-based assays.
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| ln Vivo |
In vivo, Solvent Yellow 93 is not used as a therapeutic agent; it is primarily an industrial and consumer product colorant. However, due to its widespread use, there is potential for human exposure through inhalation, dermal contact, or ingestion. The compound's insolubility in water and solubility in organic solvents suggest that it may be absorbed and distributed in lipid-rich tissues if exposure occurs. Its environmental fate and potential for bioaccumulation are important considerations in the context of its industrial use.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays are not applicable to Solvent Yellow 93, as it is not a pharmacologically active compound. However, its physicochemical properties, such as solubility and stability, can be determined using standard protocols. Solubility is measured by adding excess dye to a solvent and determining the concentration of the dissolved compound using UV-Vis spectrophotometry. The compound's stability in various solvents can be assessed by measuring its absorbance over time. These properties are important for understanding the compound's behavior in various applications.
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| Cell Assay |
In vitro cellular experiments are not typically performed with Solvent Yellow 93, as it is not a biologically active compound. However, its potential cytotoxicity may be assessed using cell viability assays such as MTT or Alamar Blue. Cells are exposed to varying concentrations of the dye for 24-72 hours, and cell viability is measured. The IC50 value, if any, would indicate the concentration at which the dye reduces cell viability by 50%. Such studies are important for evaluating the safety of the compound in consumer products.
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| Animal Protocol |
In vivo animal studies are not typically conducted with Solvent Yellow 93, as it is not a therapeutic agent. However, the safety of the compound as a consumer product ingredient may be evaluated in toxicity studies. In such studies, the dye is administered to animals via oral, dermal, or inhalation routes, and the animals are monitored for signs of toxicity. Histopathological examination of tissues and analysis of clinical chemistry parameters are performed to assess the compound's safety. These studies are conducted according to regulatory guidelines for industrial chemicals.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties are not typically studied for Solvent Yellow 93, as it is not a therapeutic agent. However, if absorbed, the compound's high molecular weight (358.39 g/mol) and lipophilicity would suggest extensive tissue distribution and potential accumulation in adipose tissue. Metabolism would likely involve cytochrome P450-mediated oxidation, and excretion would occur via the biliary and renal routes. The compound's insolubility in water would limit its renal clearance. These properties are relevant for assessing the compound's safety and potential for bioaccumulation.
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| Toxicity/Toxicokinetics |
The toxicity of Solvent Yellow 93 has been evaluated in the context of its use as an industrial and consumer product dye. The compound is generally considered to have low acute toxicity. However, some azo dyes are known to be metabolized to aromatic amines, which may be carcinogenic. The safety of Solvent Yellow 93 in consumer products has been reviewed by regulatory agencies. The compound may cause skin or eye irritation upon direct contact. Standard safety precautions should be followed when handling this compound.
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| References | |
| Additional Infomation |
Solvent Yellow 93 is a synthetic azomethine dye used as a colorant in toners, solvents, oils, plastics, and fuels. Its bright yellow hue and good stability in different solvents make it a valuable dye for various industrial applications. It is also used in the formulation of marker inks and certain cosmetics. The compound is insoluble in water but soluble in organic solvents such as ethanol, chloroform, and acetone. Its safety in consumer products has been evaluated by regulatory agencies, and it is permitted for use at specified concentrations.
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| Molecular Formula |
C₂₁H₁₈N₄O₂
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|---|---|
| Molecular Weight |
358.39
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| Exact Mass |
358.142
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| CAS # |
4702-90-3
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| PubChem CID |
5705091
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| Appearance |
Yellow to orange solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
556.2±60.0 °C at 760 mmHg
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| Melting Point |
180 °C
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| Flash Point |
290.2±32.9 °C
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| Vapour Pressure |
0.0±1.5 mmHg at 25°C
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| Index of Refraction |
1.668
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| LogP |
2.31
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
27
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| Complexity |
712
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CC1=NN(C(=O)C1/C=C/2\C(=NN(C2=O)C3=CC=CC=C3)C)C4=CC=CC=C4
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| InChi Key |
QPAPQRFSPBUJAU-CPNJWEJPSA-N
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| InChi Code |
InChI=1S/C21H18N4O2/c1-14-18(20(26)24(22-14)16-9-5-3-6-10-16)13-19-15(2)23-25(21(19)27)17-11-7-4-8-12-17/h3-13,18H,1-2H3/b19-13+
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| Chemical Name |
(4E)-5-methyl-4-[(3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-yl)methylidene]-2-phenylpyrazol-3-one
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| Synonyms |
Solvent Yellow 93; Solvent Yellow 93
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~6.25 mg/mL (~17.44 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7903 mL | 13.9513 mL | 27.9026 mL | |
| 5 mM | 0.5581 mL | 2.7903 mL | 5.5805 mL | |
| 10 mM | 0.2790 mL | 1.3951 mL | 2.7903 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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