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| 10mg |
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Purity: ≥98%
Solasodine is a naturally occuring and poisonous alkaloid chemical compound found in plants of the Solanaceae family. It is an antioxidant glycoalkaloid of Solanum species.
| ln Vitro |
After two days of treatment with solasodine (90 μM), P19 cells exhibited substantial budding. Strong expression of various neuronal markers, including as βIII-tubulin, synaptophysin, MAP2, ChAT, and the neuroblast marker doublecortin, was induced by solasodine. P19 cells are stimulated to differentiate by solasodine, mostly along neural routes [1]. By suppressing the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins, solasodine causes apoptosis [3].
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| ln Vivo |
In PCT-induced convulsions, solasodine (25–100 mg/kg; i.p.; once) therapy markedly postponed the hindlimb myotonic extensor (HLTE) phase's latency. and in a dose-dependent way greatly improved thiopental-induced sleep. Anticonvulsant and CNS depressive properties are exhibited by solasodine [2]. After two weeks of treatment with solasodine (375 μM; icv), ependymal, subventricular zone, and cortical cells that colocalized with doublecortin immunostaining showed a substantial increase in bromodeoxyuridine uptake. Rats given solanodine treatment exhibit a substantial upregulation of drug-binding translocators and cholesterol expression in ependymal cells [1].
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| Animal Protocol |
Animal/Disease Models: Swiss albino mice (18-25 g) treated with picrotoxin (PCT) or thiopental [2]
Doses: 25 mg/kg, 50 mg/kg and 100 mg/kg Route of Administration: i.p. Injection; Experimental Results: Latency of the hindlimb myotonic extensor (HLTE) phase was Dramatically delayed in PCT-induced convulsions. and Dramatically enhanced thiopental-induced sleep in a dose-dependent manner. |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
LABELED SOLASODINE WAS INJECTED INTO 2 NORMAL MEN AND INTO SYRIAN HAMSTERS. IN BOTH MEN, BLOOD (3)H WAS LARGELY ASSOCIATED WITH ERYTHROCYTES WHICH AFTER 8 DAYS STILL ACCOUNTED FOR 3.3% OF THE DOSE; PLASMA CONTAINED 1.6%, URINE 7% AND FECES 20% OF THE DOSE. EXCRETION OF (3)H BY HAMSTERS HAD DECLINED TO A VERY LOW LEVEL AFTER 8 DAYS WHEN 22-30% OF THE DOSE HAD BEEN EXCRETED. UNCHANGED SOLASODINE WAS STILL DETECTABLE IN LIVER 22 DAYS AFTER ADMIN. |
| References |
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| Additional Infomation |
Solasodine has been reported in Solanum violaceum, Solanum aviculare, and other organisms with data available.
See also: Solasodine (annotation moved to). |
| Molecular Formula |
C27H43NO2
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|---|---|
| Molecular Weight |
413.6358
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| Exact Mass |
413.329
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| CAS # |
126-17-0
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| PubChem CID |
5250
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| Appearance |
White to off-white solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
537.9±50.0 °C at 760 mmHg
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| Melting Point |
284 °C (dec.)(lit.)
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| Flash Point |
279.1±30.1 °C
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| Vapour Pressure |
0.0±3.2 mmHg at 25°C
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| Index of Refraction |
1.572
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| LogP |
5.78
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
30
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| Complexity |
749
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
KWVISVAMQJWJSZ-FIBXIUFESA-N
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| InChi Code |
InChI=1S/C27H43NO2/c1-16-7-12-27(28-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(29)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28-29H,6-15H2,1-4H3/t16-,17-,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1
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| Chemical Name |
(4S,5'R,6aR,6bS,8aS,8bR,9R,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,4,5,6,6a,6b,7,8,8a,8b,9,11a,12,12a,12b-hexadecahydrospiro[naphtho[2',1'
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| Synonyms |
Solasodine Purapuridine Salasdine Solancarpidine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
Ethanol : ~20 mg/mL (~48.35 mM)
DMSO : ~1.96 mg/mL (~4.74 mM) H2O : ~0.67 mg/mL (~1.62 mM) |
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4176 mL | 12.0878 mL | 24.1756 mL | |
| 5 mM | 0.4835 mL | 2.4176 mL | 4.8351 mL | |
| 10 mM | 0.2418 mL | 1.2088 mL | 2.4176 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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