| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| Other Sizes |
| Targets |
Sodium lauroyl glutamate functions as a surfactant, reducing the surface tension of aqueous solutions to aid in the removal of dirt and oil. As an anionic surfactant, it has a negative charge that helps to emulsify and suspend oils and particles. It does not target a specific biological receptor but acts through its physicochemical properties.
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|---|---|
| ln Vitro |
In vitro, Sodium lauroyl glutamate (1% w/w) acts as a mild surfactant. Its activity is characterized by its ability to reduce surface tension and form micelles. It has been shown to have irritant contact dermatitis potential but may also have anti-irritant potential on human skin surfaces in active agent mixtures.
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| ln Vivo |
In vivo, Sodium lauroyl glutamate is used in cleaning products for its surfactant properties. It is not a therapeutic agent and is not administered systemically. Its effects are localized to the skin and mucous membranes when used in topical formulations. It is considered safe for use in cosmetics and personal care products.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays are not applicable for Sodium lauroyl glutamate, as it is a surfactant and not a pharmacologically active compound targeting specific enzymes or receptors. Its activity is based on its physicochemical properties as a surfactant, which can be assessed by measuring surface tension, critical micelle concentration, and foaming properties.
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| Cell Assay |
In vitro cellular assays for Sodium lauroyl glutamate typically involve testing its irritancy potential on skin cell models. The compound's effects on cell viability and barrier function are assessed using reconstructed human epidermis or other in vitro skin models. These assays help evaluate its safety for use in cosmetic products.
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| Animal Protocol |
In vivo animal models are not typically used for Sodium lauroyl glutamate as a therapeutic agent, as it is a surfactant used in personal care products. Its safety and irritation potential are evaluated through standard dermatological testing, such as patch tests on human volunteers, rather than animal models.
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| ADME/Pharmacokinetics |
Sodium lauroyl glutamate has a molecular formula of C17H30NNaO5 and a molecular weight of 351.4 g/mol. Its IUPAC name is sodium (2S)-2-(dodecanoylamino)-5-hydroxy-5-oxopentanoate. It is also known as Sodium N-lauroylglutamate and Amisoft LS 11. It is a white powder or solid that is soluble in water.
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| Toxicity/Toxicokinetics |
Sodium lauroyl glutamate is considered a mild and safe surfactant with low irritation potential. It is biodegradable and derived from natural sources. It is not intended for human therapeutic use but is widely used in cosmetic and personal care products. Standard safety precautions for handling surfactants should be followed.
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| Additional Infomation |
Sodium lauroyl glutamate (CAS# 29923-31-7) is an amino acid anionic surfactant derived from glutamic acid and lauric acid. It is a mild surfactant used as a gentle cleanser in personal care products. It is biodegradable and has low irritation potential. The compound is for research use only and is not approved for human therapeutic use.
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| Molecular Formula |
C17H30NNAO5
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|---|---|
| Molecular Weight |
351.41
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| Exact Mass |
350.194
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| CAS # |
29923-31-7
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| Related CAS # |
29047-63-0 (Parent)
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| PubChem CID |
23668603
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| Appearance |
White to off-white solid powder
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| Boiling Point |
543.6ºC at 760 mmHg
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| Flash Point |
282.6ºC
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| LogP |
2.397
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
15
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| Heavy Atom Count |
24
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| Complexity |
363
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| Defined Atom Stereocenter Count |
1
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| SMILES |
CCCCCCCCCCCC(N[C@@H](CCC(O)=O)C([O-])=O)=O.[Na+]
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| InChi Key |
IWIUXJGIDSGWDN-UQKRIMTDSA-M
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| InChi Code |
InChI=1S/C17H31NO5.Na/c1-2-3-4-5-6-7-8-9-10-11-15(19)18-14(17(22)23)12-13-16(20)21;/h14H,2-13H2,1H3,(H,18,19)(H,20,21)(H,22,23);/q;+1/p-1/t14-;/m0./s1
|
| Chemical Name |
sodium;(2S)-2-(dodecanoylamino)-5-hydroxy-5-oxopentanoate
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| Synonyms |
Amisoft LS 11; Hostapon CLG; Sodium lauroyl glutamate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~5 mg/mL (~14.23 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8457 mL | 14.2284 mL | 28.4568 mL | |
| 5 mM | 0.5691 mL | 2.8457 mL | 5.6914 mL | |
| 10 mM | 0.2846 mL | 1.4228 mL | 2.8457 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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