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    Sinomenine (Cucoline)
    Sinomenine (Cucoline)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1755
    CAS #: 568-72-9 Purity ≥98%

    Description: Sinomenine (Coculine; Cucoline; Kukoline) is a naturally occuring alkaloid found in the root of the climbing plant Sinomenium acutum which is native to Japan and China. It is traditionally used in herbal medicine in these countries, as a treatment for rheumatism and arthritis. However, its analgesic action against other kinds of pain is limited. Sinomenine is a morphinan derivative, related to opioids such as levorphanol and the non-opioid cough suppressant dextromethorphan. 

    References: Biol Pharm Bull. 2005 Jan;28(1):105-9; Acta Med Okayama. 1976 Feb;30(1):1-20.

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    Molecular Weight (MW)329.39
    FormulaC19H23NO4 
    CAS No.115-53-7  
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: > 10 mM                   
    Water: N/A
    Ethanol: N/A
    Other info

    Chemical Name: (9alpha,13alpha,14alpha)-7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one

    InChi Key: INYYVPJSBIVGPH-WTOJCKNJSA-N

    InChi Code: InChI=1S/C19H23NO4/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19/h4-5,9,12-13,22H,6-8,10H2,1-3H3/t12-,13-,19+/m0/s1

    SMILES Code: [H][[email protected]]1([[email protected]@]2(C3)C4=C(O)C(OC)=CC=C4C[[email protected]]1([H])N(C)CC2)C=C(OC)C3=O           

    SynonymsCoculine; Cucoline; Kukoline


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