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    (Sar1,Val5,Ala8)-Angiotensin II
    (Sar1,Val5,Ala8)-Angiotensin II

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V34902
    CAS #: 34273-10-4Purity ≥98%

    Description: Saralasin [(Sar1,Val5,Ala8)-Angiotensin II], a peptide compound, is a partial agonist/competitive non-selective antagonist of angiotensin II receptors, though it is commonly mistaken as a competitive antagonist. Saralasin's distinction as a partial agonist is based on the fact that its therapeutic effect (i.e. reduced hypertension) is only observed in patients with high plasma angiotensin II levels, but in patients with low angiotensin II levels Saralasin causes hypertension. In other words, the effects of Saralasin on the angiotensin II receptor in the absence of angiotensin II is pharmacodynamically similar to angiotensin II itself thus it is a partial agonist, because if it was an antagonist it would not elicit an effect when bound to its receptor. Saralasin is an angiotensin II analogue, containing sarcosine-1 and alanine-8, hence the name (sarcosine, alanine, angiotensin). 

    ReferencesIp S, Tsang S, Wong T, Che C, Leung P (2003). 'Saralasin, a nonspecific angiotensin II receptor antagonist, attenuates oxidative stress and tissue injury in cerulein-induced acute pancreatitis'. Pancreas. 26 (3): 224–9. 

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    Molecular Formula: C42H65N13O10 

    M.W.: 912

    Chemical Name: (S)-2-((R)-1-((6S,9S,12S,15R,18R)-18-((1H-imidazol-5-yl)methyl)-6-(3-((diaminomethylene)amino)propyl)-12-(4-hydroxybenzyl)-9,15-diisopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecan-19-oyl)pyrrolidine-2-carboxamido)propanoic acid

    SMILES O=C([[email protected]@H](CC1=CN=CN1)NC([[email protected]@H](C(C)C)NC([[email protected]](CC(C=C2)=CC=C2O)NC([[email protected]](C(C)C)NC([[email protected]](CCC/N=C(N)\N)NC(CNC)=O)=O)=O)=O)=O)N3[[email protected]@H](C(N[[email protected]](C(O)=O)C)=O)CCC3

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