Sabcomeline (BCI-224; BRL-55473; CEB-2424; SB-202026A) is a novel, potent and selective M1 receptor partial agonist that was under development for the treatment of Alzheimer's disease. It was advanced to phase III clinical trials before being discontinued due to unsatisfactory results.
McArthur RA, Gray J, Schreiber R. Cognitive effects of muscarinic M1 functional agonists in non-human primates and clinical trials. Curr Opin Investig Drugs. 2010 Jul;11(7):740-60. Review. PubMed PMID: 20571970.
|Related CAS #||
159912-58-0 (HCl);159912-53-5(free base)
(R)-3-Quinuclidineglyoxylonitrile (Z)-O-methyloxime, monohydrochloride
BCI-224 BRL-55473 CEB-2424 SB-202026A BCI224 BRL55473 CEB2424 SB202026A. Memric.
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|Preparing Stock Solutions||1 mg||5 mg||10 mg|
|1 mM||5.1746 mL||25.8732 mL||51.7464 mL|
|5 mM||1.0349 mL||5.1746 mL||10.3493 mL|
|10 mM||0.5175 mL||2.5873 mL||5.1746 mL|
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
In vivo formula preparation method：take μL DMSO mother liquor，join μL Corn oil，mix well and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.