Sabcomeline HCl

Alias: BCI-224 BRL-55473 CEB-2424 SB-202026A BCI224 BRL55473 CEB2424 SB202026A. Memric.

Cat No.:V12525 Purity: ≥98%

COA Product Data Instructions for use SDS

Sabcomeline (BCI-224; BRL-55473; CEB-2424; SB-202026A) is a novel, potent and selective M1 receptor partial agonist that was under development for the treatment of Alzheimers disease.

Sabcomeline HCl Chemical Structure CAS No.: 159912-58-0
Product category: New1

This product is for research use only, not for human use. We do not sell to patients.

Size	Price
5mg
50mg
500mg

BULK INQUIRY

1-708-310-1919 [email protected]

Other Forms of Sabcomeline HCl:

Sabcomeline

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Product Description
Bioactivity & Protocols
Physicochemical Properties
Solubility Data
Calculators
Related Products

Product Description

Sabcomeline (BCI-224; BRL-55473; CEB-2424; SB-202026A) is a novel, potent and selective M1 receptor partial agonist that was under development for the treatment of Alzheimer's disease. It was advanced to phase III clinical trials before being discontinued due to unsatisfactory results.

Biological Activity I Assay Protocols (From Reference)

References	McArthur RA, Gray J, Schreiber R. Cognitive effects of muscarinic M1 functional agonists in non-human primates and clinical trials. Curr Opin Investig Drugs. 2010 Jul;11(7):740-60. Review. PubMed PMID: 20571970.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Physicochemical Properties

Molecular Formula	C10H16CLN3O
Molecular Weight	193.2456
CAS #	159912-58-0
Related CAS #	159912-58-0 (HCl);159912-53-5(free base)
SMILES	N#C/C([C@H]1CN2CCC1CC2)=N\OC.[H]Cl
InChi Key	INJWRVWKJFJRFO-SCRZZQONSA-N
InChi Code	InChI=1S/C10H15N3O.ClH/c1-14-12-10(6-11)9-7-13-4-2-8(9)3-5-13/h8-9H,2-5,7H2,1H31H/b12-10+/t9-/m0./s1
Chemical Name	(R)-3-Quinuclidineglyoxylonitrile (Z)-O-methyloxime, monohydrochloride
Synonyms	BCI-224 BRL-55473 CEB-2424 SB-202026A BCI224 BRL55473 CEB2424 SB202026A. Memric.
Storage	Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	5.1746 mL	25.8732 mL	51.7464 mL
	5 mM	1.0349 mL	5.1746 mL	10.3493 mL
	10 mM	0.5175 mL	2.5873 mL	5.1746 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

Molarity Calculator allows you to calculate the mass, volume, and/or concentration required for a solution, as detailed below:

Calculate the Mass of a compound required to prepare a solution of known volume and concentration
Calculate the Volume of solution required to dissolve a compound of known mass to a desired concentration
Calculate the Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of molarity calculation using the molarity calculator is shown below:
What is the mass of compound required to make a 10 mM stock solution in 5 ml of DMSO given that the molecular weight of the compound is 350.26 g/mol?

Enter 350.26 in the Molecular Weight (MW) box
Enter 10 in the Concentration box and choose the correct unit (mM)
Enter 5 in the Volume box and choose the correct unit (mL)
Click the “Calculate” button
The answer of 17.513 mg appears in the Mass box. In a similar way, you may calculate the volume and concentration.

Dilution Calculator allows you to calculate how to dilute a stock solution of known concentrations. For example, you may Enter C1, C2 & V2 to calculate V1, as detailed below:

What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=25 μM, V2=25 ml and V1 is the unknown:

Enter 10 into the Concentration (Start) box and choose the correct unit (mM)
Enter 25 into the Concentration (End) box and select the correct unit (mM)
Enter 25 into the Volume (End) box and choose the correct unit (mL)
Click the “Calculate” button
The answer of 62.5 μL (0.1 ml) appears in the Volume (Start) box

Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:

Note: Chemical formula is case sensitive: C12H18N3O4 c12h18n3o4
Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter the chemical/molecular formula and click the “Calculate’ button.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (or molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Reconstitution Calculator allows you to calculate the volume of solvent required to reconstitute your vial.

Enter the mass of the reagent and the desired reconstitution concentration as well as the correct units
Click the “Calculate” button
The answer appears in the Volume (to add to vial) box

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)

Dosage mg/kg

Average weight of animals g

Dosing volume per animal μL

Number of animals

Step 2: Enter in vivo formulation (This is only a calculator, not the exact formulation for a specific product. Please contact us first if there is no in vivo formulation in the solubility section.)

% DMSO

% Tween 80

% ddH₂O

Calculate Reset

Calculation results

Working concentration： mg/mL；

Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O，mix and clarify.

Note： (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.