| Size | Price | Stock | Qty |
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| Targets |
The specific molecular targets of Rubrofusarin are not well characterized in the available literature. As a polyketide-derived naphthopyranone, it may interact with various cellular targets, including enzymes and receptors. It has been reported to have antimicrobial and cytotoxic activities, suggesting it may affect cell wall synthesis, protein synthesis, or other essential cellular processes.
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| ln Vitro |
Rubrofusarin has demonstrated antimicrobial activity in vitro against various bacterial and fungal species. It has also shown cytotoxic activity against cancer cell lines. Specific IC50 values are not detailed in the available literature. Its activity is typically assessed using standard antimicrobial susceptibility tests and cell viability assays.
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| ln Vivo |
Specific in vivo data for Rubrofusarin is not detailed in the available literature. As a natural product with antimicrobial and cytotoxic activities, it has potential for in vivo efficacy in treating infections or cancer. Further studies are needed to confirm its in vivo activity and pharmacokinetic properties.
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| Enzyme Assay |
The in vitro antimicrobial activity of Rubrofusarin is assessed using standard broth microdilution or agar diffusion assays. The compound is tested against a panel of bacterial and fungal strains, and the minimum inhibitory concentration (MIC) is determined. Cytotoxicity is assessed using cancer cell lines and measuring cell viability after treatment with the compound.
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| Cell Assay |
Cell-based assays are used to evaluate Rubrofusarin's cytotoxic activity. Various cancer cell lines are treated with Rubrofusarin at various concentrations, and cell viability is measured using MTT, XTT, or CellTiter-Glo assays. IC50 values for cytotoxicity are calculated from dose-response curves.
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| Animal Protocol |
Rubrofusarin may have been evaluated in animal models of infection or cancer. In these studies, the compound would be administered to infected or tumor-bearing animals, and its effects on disease progression or survival would be assessed. However, specific protocols are not detailed in the available literature.
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| ADME/Pharmacokinetics |
Rubrofusarin has a molecular weight of 272.25 and a molecular formula of C15H12O5. It is a yellow pigment and a polyketide-derived naphthopyranone. Purity is typically ≥98%. The compound is soluble in DMSO. Storage is recommended at -20°C. It is a natural product isolated from various fungal species.
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| Toxicity/Toxicokinetics |
Rubrofusarin is a research compound and its full toxicological profile is not detailed in the available literature. As a natural product with antimicrobial and cytotoxic activities, it may have significant toxicity at higher doses. Standard safety precautions should be followed when handling the compound.
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| References |
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| Additional Infomation |
Fusarium erythrosine belongs to the benzo[g]chromen-4-one class of compounds, with two hydroxyl substituents at positions 5 and 6, and methyl and methoxy substituents at positions 2 and 8, respectively. It is an orange polyketide pigment and a common intermediate in the biosynthetic pathways of many fungi. Fusarium erythrosine can be used as a fungal metabolite, biopigment, and EC 1.14.18.1 (tyrosinase) inhibitor. It is a benzo[g]chromenone, polyketide compound, aromatic ether, and phenolic compound. It is the conjugate acid of fusarium erythrosine (1-). Fusarium erythrosine has been reported to be found in Fusarium graminearum, Aspergillus niger, and several other organisms with relevant data.
Rubrofusarin (CAS#: 3567-00-8) is a natural product, a polyketide-derived naphthopyranone, isolated from various fungal species including Fusarium and Aspergillus. It is a yellow pigment and secondary metabolite. Rubrofusarin has demonstrated antimicrobial and cytotoxic activities in vitro. It is a valuable research compound for studying natural product chemistry, antimicrobial agents, and anticancer compounds. |
| Molecular Formula |
C15H12O5
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|---|---|
| Molecular Weight |
272.25278
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| Exact Mass |
272.068
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| CAS # |
3567-00-8
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| PubChem CID |
72537
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| Appearance |
Yellow to orange solid powder
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| Density |
1.432g/cm3
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| Boiling Point |
438.7ºC at 760mmHg
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| Melting Point |
210 - 211 °C
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| Flash Point |
167ºC
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| Index of Refraction |
1.691
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| LogP |
2.674
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
20
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| Complexity |
432
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
FPNKCZKRICBAKG-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C15H12O5/c1-7-3-10(16)14-12(20-7)5-8-4-9(19-2)6-11(17)13(8)15(14)18/h3-6,17-18H,1-2H3
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| Chemical Name |
5,6-dihydroxy-8-methoxy-2-methylbenzo[g]chromen-4-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6731 mL | 18.3655 mL | 36.7309 mL | |
| 5 mM | 0.7346 mL | 3.6731 mL | 7.3462 mL | |
| 10 mM | 0.3673 mL | 1.8365 mL | 3.6731 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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