| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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| 10g | |||
| Other Sizes |
Purity: ≥98%
| Targets |
Remdesivir impurity x does not have a specific biological target, as it is an intermediate and impurity rather than a therapeutic agent. However, as an intermediate in the synthesis of remdesivir and GS-441524, it is chemically related to these antiviral compounds. Remdesivir targets the RNA-dependent RNA polymerase (RdRp) of viruses, including SARS-CoV-2, by acting as a nucleoside analogue that terminates viral RNA chain elongation. GS-441524 is the active metabolite of remdesivir. Remdesivir impurity x is used in the synthesis of these antiviral agents and in quality control applications to ensure the purity of the final drug products.
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| ln Vitro |
In vitro studies on Remdesivir impurity x are not typically performed, as the compound is an intermediate and impurity rather than a therapeutic agent. The compound is used as an analytical reference standard in pharmaceutical analysis rather than as a bioactive compound in cell-based assays. Its chemical properties and purity are characterized using analytical techniques such as HPLC, NMR, and mass spectrometry. Remdesivir impurity x is not intended for biological testing and is strictly a research chemical for analytical applications.
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| ln Vivo |
In vivo studies on Remdesivir impurity x are not applicable, as the compound is an intermediate and impurity rather than a therapeutic agent. The compound is not intended for in vivo use or for therapeutic applications. Remdesivir impurity x is used as an analytical reference standard in pharmaceutical analysis and quality control applications. The compound's role is limited to chemical synthesis and analytical chemistry, and it does not have biological activity.
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| Enzyme Assay |
Non-cellular assays for Remdesivir impurity x are not applicable, as the compound is an intermediate and impurity rather than a therapeutic agent. The compound is used as an analytical reference standard in pharmaceutical analysis. Its chemical properties and purity are characterized using analytical techniques such as HPLC, NMR, and mass spectrometry. Remdesivir impurity x is used in method development, method validation, and quality control applications for the commercial production of remdesivir. These analytical methods are essential for ensuring the quality and purity of remdesivir drug substance and drug products.
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| Cell Assay |
In vitro cell-based assays for Remdesivir impurity x are not applicable, as the compound is an intermediate and impurity rather than a therapeutic agent. The compound is not intended for biological testing and is strictly a research chemical for analytical applications. Its use is limited to chemical synthesis and pharmaceutical analysis. Remdesivir impurity x does not have biological activity and is not used in cell-based assays.
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| Animal Protocol |
In vivo animal studies for Remdesivir impurity x are not applicable, as the compound is an intermediate and impurity rather than a therapeutic agent. The compound is not intended for in vivo use or for therapeutic applications. Its use is limited to chemical synthesis and pharmaceutical analysis. Remdesivir impurity x does not have biological activity and is not used in animal studies.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for Remdesivir impurity x are not applicable, as the compound is an intermediate and impurity rather than a therapeutic agent. The compound is not intended for in vivo use, and its pharmacokinetic properties have not been characterized. Remdesivir impurity x is used as an analytical reference standard in pharmaceutical analysis and quality control applications. Its molecular weight is 561.64 g/mol, and its molecular formula is C33H31N5O4.
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| Toxicity/Toxicokinetics |
Toxicological data for Remdesivir impurity x are not applicable, as the compound is an intermediate and impurity rather than a therapeutic agent. The compound is not intended for in vivo use, and its toxicological properties have not been characterized. Remdesivir impurity x is used as an analytical reference standard in pharmaceutical analysis and quality control applications. As a research chemical, it is intended for laboratory use only and is not for human consumption. Appropriate safety precautions should be taken when handling Remdesivir impurity x.
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| Additional Infomation |
Remdesivir impurity x (GS-441524-intermediate) is a key intermediate in the synthesis of remdesivir and GS-441524. It has the molecular formula C33H31N5O4 and CAS number 1355357-49-1. Remdesivir impurity x is used as an analytical reference standard for quality control in remdesivir production. Remdesivir is an FDA-approved antiviral drug for COVID-19. Remdesivir impurity x is not a drug and is strictly a research chemical for analytical applications.
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| Molecular Formula |
C33H31N5O4
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|---|---|
| Molecular Weight |
561.642
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| Exact Mass |
561.2376
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| Elemental Analysis |
C, 70.57; H, 5.56; N, 12.47; O, 11.39
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| CAS # |
1355357-49-1
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| PubChem CID |
101561033
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| Appearance |
Solid powder
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| LogP |
5.397
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
11
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| Heavy Atom Count |
42
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| Complexity |
883
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| Defined Atom Stereocenter Count |
4
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| SMILES |
O1[C@]([H])(C([H])([H])OC([H])([H])C2C([H])=C([H])C([H])=C([H])C=2[H])[C@]([H])([C@]([H])([C@]1(C#N)C1=C([H])C([H])=C2C(N([H])[H])=NC([H])=NN12)OC([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])OC([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H]
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| InChi Key |
PJXBLWLWNWGFJO-TXLSGFARSA-N
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| InChi Code |
InChI=1S/C33H31N5O4/c34-22-33(29-17-16-27-32(35)36-23-37-38(27)29)31(41-20-26-14-8-3-9-15-26)30(40-19-25-12-6-2-7-13-25)28(42-33)21-39-18-24-10-4-1-5-11-24/h1-17,23,28,30-31H,18-21H2,(H2,35,36,37)/t28-,30-,31-,33+/m1/s1
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| Chemical Name |
(2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-carbonitrile
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| Synonyms |
GS441524-intermediate GS 441524-intermediate GS-441524-intermediate remdesivir-intermediate Remdesivir related compound 5
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7805 mL | 8.9025 mL | 17.8050 mL | |
| 5 mM | 0.3561 mL | 1.7805 mL | 3.5610 mL | |
| 10 mM | 0.1781 mL | 0.8903 mL | 1.7805 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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