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    RA-9 UPS inhibitor
    RA-9 UPS inhibitor

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V2165
    CAS #: 919091-63-7Purity ≥98%

    Description: RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS). RA-9 Inhibits Proteasome-Associated DUBs and Ovarian Cancer in Vitro and in Vivo via Exacerbating Unfolded Protein Responses. Treatment with RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors. Loss of cell viability following RA-9 exposure is associated with an unfolded protein response as mechanism to compensate for unsustainable levels of proteotoxic stress. In vivo treatment with RA-9 retards tumor growth, increases overall survival, and was well tolerated by the host.

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    CAS: 919091-63-7
    Chemical Formula: C19H15N3O5
    Exact Mass: 365.1012
    Molecular Weight: 365.345
    Elemental Analysis: C, 62.46; H, 4.14; N, 11.50; O, 21.90

    Synonym: RA-9; RA 9; RA9; RA-9 UPS inhibitor

    Chemical Name: (3E,5E)-3,5-Bis[(4-nitrophenyl)methylene]-4-piperidinone

    InChi Key: YUYPWAMLWZVHAE-KAVGSWPWSA-N

    InChi Code: InChI=1S/C19H15N3O5/c23-19-15(9-13-1-5-17(6-2-13)21(24)25)11-20-12-16(19)10-14-3-7-18(8-4-14)22(26)27/h1-10,20H,11-12H2/b15-9+,16-10+

    SMILES Code: O=C1/C(CNC/C1=C\C2=CC=C([N+]([O-])=O)C=C2)=C/C3=CC=C([N+]([O-])=O)C=C3


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    These protocols are for reference only. InvivoChem does not independently validate these methods.

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