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    (R)-Zanubrutinib
    (R)-Zanubrutinib

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V3391
    CAS #: 1691249-44-1Purity ≥98%

    Description: (R)-Zanubrutinib is the R-enantiomer of Zanubrutinib (formerly known as BGB-3111) which is a novel, highly selective, second generation BTK inhibitor, currently under clinical investigation in hematological cancers. In both biochemical and cellular assays, BGB-3111 demonstrated nanomolar BTK inhibition activity. In several MCL and DLBCL cell lines, BGB-3111 inhibited BCR aggregation-triggered BTK autophosphorylation, blocked downstream PLC-γ2 signaling, and potently inhibited cell proliferation. In comparison with ibrutinib, BGB-3111 showed much more restricted off-target activities against a panel of kinases, including ITK. While ibrutinib significantly inhibited rituximab-induced NK cell IFN-γ secretion and in vitro cytotoxicity on mantle cell lymphoma cells, BGB-3111 was at least 10-fold weaker than ibrutinib in inhibiting rituximab induced ADCC, consistent with its weak ITK inhibition activity. 

    References: Cancer Res 2015;75(15 Suppl):Abstract nr 2597.

    Related CAS#:1633350-06-7 (racemic); 1691249-45-2 (S-isomer) 

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    Molecular Weight (MW) 471.56
    Formula C27H29N5O3
    CAS No.1691249-44-1 (R-isomer); 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO:  ≥ 50 mg/mL 
    Water:  <1 mg/mL 
    Ethanol: <1 mg/mL
    Chemical Name (7R)-4,5,6,7-Tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
    Synonyms BGB-3111; BGB 3111; BGB3111
    SMILES Code O=C(C1=C2NCC[[email protected]@H](C3CCN(C(C=C)=O)CC3)N2N=C1C4=CC=C(OC5=CC=CC=C5)C=C4)N


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