Quercetin (Sophoretin; NSC 9221; Kvercetin)

Alias: NSC 9221; NCI-C60106; NSC 9219; Meletin; Quercetin; Kvercetin; Quercetine; Quercetol; Quertine; Sophoretin; Xanthaurine
Cat No.:V0147 Purity: ≥98%
Quercetin (Sophoretin; NSC-9221; Kvercetin) is a natural flavonoid isolated from various vegetables, fruits and wine.
Quercetin (Sophoretin; NSC 9221; Kvercetin) Chemical Structure CAS No.: 117-39-5
Product category: PI3K
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
500mg
1g
5g
10g
25g
50g
Other Sizes

Other Forms of Quercetin (Sophoretin; NSC 9221; Kvercetin):

  • Quercetin-d3 (quercetin d3)
  • Quercetin Dihydrate
  • Quercetin hydrate
  • Quercetin-d5 (quercetin d5)
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Quercetin (Sophoretin; NSC-9221; Kvercetin) is a natural flavonoid isolated from various vegetables, fruits and wine. Quercetin has been reported to possess a variety of biological activities including anti-inflammatory, anti-oxidant and pro-apoptotic functions in cancer cells. As a PI3K inhibitor with an IC50 range of 2.4–5.4 μMand as a stimulator of recombinant SIRT1, it inhibited tumor growth in various ways. Because it is advantageous for diabetics, quercetin is a component of many dietary supplements.

Biological Activity I Assay Protocols (From Reference)
Targets
PI3Kδ (IC50 = 2.4 μM); PI3Kγ (IC50 = 3 μM); PI3Kβ (IC50 = 5.4 μM); Autophagy; Mitophagy
ln Vitro
Quercetin, a flavonol and a plant-derived flavonoid, is a type of plant-based chemical, or phytochemical, that can be found in fruits, vegetables, leaves, and grains. Supplements, drinks, and foods may all contain it as an ingredient. It is being researched for a wide range of potential health benefits, including anti-inflammatory and antioxidant properties that have been suggested by several studies. With an IC50 range of 2.4 to 5.4 M, quercetin (Sophoretin) inhibits PI3K. It severely inhibited PI3K and Src kinases, only slightly affected Akt1/2, PKC, p38, and ERK1/2, and barely had any effect on PI3K and Src kinases.[1] Quercetin blocks TNF-induced LDH% release, EC-dependent neutrophil adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation.[2]
ln Vivo
Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.[3]
Enzyme Assay
Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation.
Cell Assay
Cells were treated with various concentrations of drug for 24 h.
Animal Protocol
On the right back of mice, 2×108 LNCaP cells and 5 105 PC-3 cells suspended in 100 liters of matrigel and PBS are inoculated subcutaneously. Mice are randomly assigned to four groups (n=8 in each group) and treated intraperitoneally when xenograft tumors have grown to a volume of about 100 mm3.
References

[1]. Fitoterapia . 2010 Mar;81(2):75-80.

[2]. Yao Xue Xue Bao . 1996;31(3):176-81.

[3]. PLoS One . 2015 May 26;10(5):e0128277.

These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C15H10O7
Molecular Weight
302.2357
Exact Mass
302.0427
Elemental Analysis
C, 59.61; H, 3.34; O, 37.05
CAS #
117-39-5
Appearance
Solid powder
SMILES
C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O
InChi Key
REFJWTPEDVJJIY-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
Chemical Name
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one
Synonyms
NSC 9221; NCI-C60106; NSC 9219; Meletin; Quercetin; Kvercetin; Quercetine; Quercetol; Quertine; Sophoretin; Xanthaurine
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: ~61 mg/mL (~201.8 mM)
Water: <1 mg/mL
Ethanol: ~10 mg/mL (~33.1 mM)
Solubility (In Vivo)
2% DMSO+30% PEG 300+2% Tween 80+ddH2O: 6mg/mL (Please use freshly prepared in vivo formulations for optimal results.)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 3.3086 mL 16.5431 mL 33.0863 mL
5 mM 0.6617 mL 3.3086 mL 6.6173 mL
10 mM 0.3309 mL 1.6543 mL 3.3086 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

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An example of molarity calculation using the molarity calculator is shown below:
What is the mass of compound required to make a 10 mM stock solution in 5 ml of DMSO given that the molecular weight of the compound is 350.26 g/mol?
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Dilution Calculator allows you to calculate how to dilute a stock solution of known concentrations. For example, you may Enter C1, C2 & V2 to calculate V1, as detailed below:

What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=25 μM, V2=25 ml and V1 is the unknown:
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g/mol

Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:

Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
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In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)
Step 2: Enter in vivo formulation (This is only a calculator, not the exact formulation for a specific product. Please contact us first if there is no in vivo formulation in the solubility section.)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
             (2) Be sure to add the solvent(s) in order.

Clinical Trial Information
NCT Number Status Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01720147 Active
Recruiting
Drug: Quercetin
(dietary supplement)
Fanconi Anemia Children's Hospital Medical
Center, Cincinnati
July 2012 Phase 1
NCT04907253 Active
Recruiting
Drug: Quercetin
Drug: Placebo
Coronary Artery Disease Montreal Heart Institute June 4, 2021 Phase 2
NCT04313634 Active
Recruiting
Drug: Fisetin
Drug: Quercetin
Healthy Sundeep Khosla, M.D. June 9, 2020 Phase 2
NCT02226484 Completed Drug: Quercetin GERD
Reflux
University of North Carolina,
Chapel Hill
August 2014 Phase 1
NCT03476330 Recruiting Drug: Quercetin
(dietary supplement)
Fanconi Anemia
Squamous Cell Carcinoma
Children's Hospital Medical
Center, Cincinnati
May 8, 2018 Phase 2
Biological Data
  • Quercetin

    Quercetin combined with 2-ME enhanced inhibition of PC-3 xenograft tumor growth. Yang F, et al. PLoS One. 2015, 10(5), e0128277.

  • Quercetin


    Quercetin combined with 2-ME decreased pAKT protein expression in PC-3 and LNCaP xenograft tumor tissues.

  • Quercetin

    Quercetin combined with 2-ME decreased VEGF protein and mRNA in PC-3 and LNCaP xenograft tumor tissues.

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