My cart
In the shopping cart is not goods, to choose and buy!
  • Product Name
  • Size
  • Quantity
  • Amount
    Selected items : 0 pieces Total : CHECK OUT()
    Quercetin (Sophoretin; NSC 9221; Kvercetin)
    Quercetin (Sophoretin; NSC 9221; Kvercetin)

    Price:
    Market Price:

    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V0147
    CAS #: 117-39-5Purity ≥98%

    Description: Quercetin (Sophoretin; NSC-9221; Kvercetin) is a natural flavonoid isolated from various vegetables, fruits and wine. Quercetin has been reported to possess a variety of biological activities including anti-inflammatory, anti-oxidant and pro-apoptotic functions in cancer cells. It inhibited tumor growth with different mechanisms such as acting as a PI3K inhibitor with IC50 of 2.4-5.4 μM, and also as a stimulator of recombinant SIRT1Quercetin is an ingredient of many nutritional products as it is also beneficial for diabetics. 

    References: PLoS One. 2015 May 26;10(5):e0128277; Fitoterapia. 2010 Mar;81(2):75-80.

    Related CAS #: 482-35-9 (EMIQ; Isoquercetin); 17-39-5 (quercetin)    

    Customer Validation
    Official Supplier of
    • VE
    • OF
    • YALE
    • hhmi
    • 香港大学
    Related Products
    Publications Citing InvivoChem Products
    • Physicochemical and Storage Information
    • Protocol
    • Quality Control Documentation
    • Related Biological Data
    • Customer Review

    Molecular Weight (MW)

    302.24

    Formula

    C15H10O7

    CAS No.

    117-39-5

    Storage

    -20℃ for 3 years in powder form

    -80℃ for 2 years in solvent

    Solubility (In vitro)

    DMSO: 61 mg/mL (201.8 mM)

    Water:<1 mg/mL

    Ethanol: 10 mg/mL (33.1 mM)

    Other info

    Synonym: NCI-C60106; NSC 9219; NSC 9221; Kvercetin; Meletin; Quercetin; Quercetine; Quercetol; Quertine; Sophoretin; Xanthaurine.

    InChi Key: REFJWTPEDVJJIY-UHFFFAOYSA-N

    InChi Code: InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H

    SMILES Code: O=C1C(O)=C(C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13

    Chemical Name

    2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one


    • Molarity Calculator
    • Dilution Calculator
    • The molarity calculator equation

      Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

      • Mass
      • Concentration
      • Volume
      • Molecular Weight *
      • =
      • ×
      • ×
    • The dilution calculator equation

      Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

      This equation is commonly abbreviated as: C1V1 = C2V2

      • Concentration (start)
      • ×
      • Volume (start)
      • =
      • Concentration (final)
      • ×
      • Volume (final)
      • ×
      • =
      • ×
      • C1
      •  
      • V1
      •  
      • C2
      •  
      • V2

    In Vitro

    Kinase Assay: Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation.


    Cell Assay: Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation.

    In Vivo

    Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth. LD50: >3000mg/kg (i.g.)

    Animal model

    Mice bearing LNCaP xenografts or PC-3 xenografts

    Formulation & Dosage

    Dissolved in 25% hydroxypropyl-β-cyclodextrin; 75 mg/kg

    References

    [1] Yang F, et al. PLoS One. 2015, 10(5), e0128277.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Quercetin

    Quercetin combined with 2-ME enhanced inhibition of PC-3 xenograft tumor growth. Yang F, et al. PLoS One. 2015, 10(5), e0128277.

    Quercetin


    Quercetin combined with 2-ME decreased pAKT protein expression in PC-3 and LNCaP xenograft tumor tissues.

    Quercetin

    Quercetin combined with 2-ME decreased VEGF protein and mRNA in PC-3 and LNCaP xenograft tumor tissues.


    评论

      Home Prev Next Last page / pices

      发评论

      ×
      Your information is safe with us. * Required Fields.
      Products are for research use only;  We do not sell to patients
      Tel: 1-708-310-1919
      Fax: 1-708-557-7486
      Subscribe to our E-newsletter
      • Name*
      • *
      • E-mail*
      • *
      • instructions:
      • *
      Copyright 2020 InvivoChem LLC | All Rights Reserved
      prompt
      Do you confirm the receipt?