| Size | Price | Stock | Qty |
|---|---|---|---|
| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg | |||
| Other Sizes |
| Targets |
Propan-2-amine-d6 HCl does not target a specific protein in drug research. It serves as an analytical internal standard and tracer. The deuterium labels (six hydrogen atoms replaced with deuterium) provide a mass shift, allowing precise differentiation from unlabeled isopropylamine in LC-MS or GC-MS analysis.
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|---|---|
| ln Vitro |
Drug compounds have included stable heavy isotopes of carbon, hydrogen, and other elements, mostly as quantitative tracers while the drugs were being developed. Because deuteration may affect a drug's pharmacokinetics and metabolic properties, it is a cause for concern [75].
Propan-2-amine-d6 HCl is not typically used in bioactivity assays. Its unlabeled counterpart, isopropylamine, is a simple aliphatic amine used in various chemical syntheses. As an analytical standard, the labeled compound is used to quantify isopropylamine levels in metabolic or environmental studies. |
| ln Vivo |
Dedicated in vivo activity studies are not performed for this stable isotope-labeled compound. It is used as an internal standard in PK studies to quantify the concentration of unlabeled isopropylamine or related drugs that are metabolized to isopropylamine in biological samples.
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| Enzyme Assay |
Propan-2-amine-d6 HCl is used as an analytical internal standard. In a typical assay, a known amount of the labeled compound is spiked into a biological sample (e.g., plasma, urine, tissue homogenate). The sample is then extracted and analyzed by LC-MS/MS. The deuterated compound serves as an internal standard for quantification of the unlabeled analyte.
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| Cell Assay |
Propan-2-amine-d6 HCl is not typically used in cell-based assays. Its primary application is in analytical chemistry rather than biological activity testing. It may be used to validate analytical methods for measuring isopropylamine in cell culture media or cell lysates.
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| Animal Protocol |
In animal PK studies, Propan-2-amine-d6 HCl is used as an internal standard. The unlabeled isopropylamine is administered to animals, and the labeled compound is added to the collected plasma or tissue samples before extraction and LC-MS/MS analysis to accurately quantify the unlabeled isopropylamine concentration.
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| ADME/Pharmacokinetics |
As an internal standard, Propan-2-amine-d6 HCl is not administered to animals for PK assessment of itself. Its PK properties are expected to be identical to unlabeled isopropylamine. Isopropylamine is rapidly absorbed and metabolized, with a short half-life. Detailed PK parameters are not typically reported.
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| Toxicity/Toxicokinetics |
Propan-2-amine-d6 HCl is a stable isotope-labeled compound. At the trace levels used as an internal standard, it poses no toxicity risk. Unlabeled isopropylamine can be toxic at high doses, causing skin, eye, and respiratory irritation. Standard laboratory safety precautions for chemical handling apply.
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| References | |
| Additional Infomation |
Propan-2-amine-d6 HCl is a stable isotope-labeled chemical used as an analytical internal standard. It is supplied as the hydrochloride salt for improved stability. The compound is strictly for research use and is not a therapeutic drug. Its isotopic purity is typically >98%.
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| Molecular Formula |
C3H3D6N.CLH
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|---|---|
| Molecular Weight |
101.60800
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| Exact Mass |
101.088
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| CAS # |
126794-59-0
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| PubChem CID |
12203883
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| Appearance |
White to off-white solid powder
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| LogP |
1.855
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
5
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| Complexity |
10.8
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| Defined Atom Stereocenter Count |
0
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| SMILES |
[2H]C([2H])([2H])C(C([2H])([2H])[2H])N.Cl
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| InChi Key |
ISYORFGKSZLPNW-TXHXQZCNSA-N
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| InChi Code |
InChI=1S/C3H9N.ClH/c1-3(2)4;/h3H,4H2,1-2H3;1H/i1D3,2D3;
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| Chemical Name |
1,1,1,3,3,3-hexadeuteriopropan-2-amine;hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~150 mg/mL (~1476.23 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 9.8416 mL | 49.2078 mL | 98.4155 mL | |
| 5 mM | 1.9683 mL | 9.8416 mL | 19.6831 mL | |
| 10 mM | 0.9842 mL | 4.9208 mL | 9.8416 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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