| Targets |
2-(Methylamino)ethanol does not have a specific biological target. It is an industrial chemical and synthetic building block rather than a bioactive compound. Its primary use is in organic synthesis, where it serves as an intermediate for manufacturing various chemicals, including pharmaceuticals. It is not used as a drug or therapeutic agent targeting specific enzymes or receptors.
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| ln Vitro |
Specific in vitro activity data is not applicable. 2-(Methylamino)ethanol is not a bioactive compound and is not evaluated in standard cell-based or biochemical assays for pharmacological activity. Its "activity" is chemical rather than biological, referring to its reactivity as an intermediate in synthesis reactions such as amidation or esterification.
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| ln Vivo |
Specific in vivo activity data is not applicable. The compound is not administered to animals for therapeutic purposes. It is an industrial chemical and research reagent used exclusively in synthetic chemistry. No efficacy studies in animal models have been reported.
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| Enzyme Assay |
Not applicable. 2-(Methylamino)ethanol is not used in cell-free binding assays. It is a chemical reagent for synthesis. Its characterization involves standard analytical methods such as GC, NMR, and titration to determine purity and identity. It is not used to study enzyme inhibition or receptor binding.
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| Cell Assay |
Not applicable. The compound is not tested in cell-based assays because it has no direct biological activity. It is used as a synthetic intermediate, not as a treatment for cells. However, its hydrochloride salt forms may be used in buffer preparations or as a reagent, but not for studying cell signaling or viability.
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| Animal Protocol |
Not applicable. 2-(Methylamino)ethanol is not used in animal studies as a test article. It is an industrial chemical and building block. Any in vivo applications would be for the final drug molecules synthesized using this intermediate, not for the intermediate itself.
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| ADME/Pharmacokinetics |
Metabolism / Metabolites
An in vivo precursor of choline. 2-Methylaminoethanol phosphate was observed to be incorporated into the phospholipids of brain and liver suspensions. Specific pharmacokinetic data is not applicable. The compound is a synthetic intermediate, not an active pharmaceutical ingredient. Its own ADME properties are irrelevant. If absorbed, it would be a small, water-soluble amine, but no such studies have been conducted for its use as a drug. |
| Toxicity/Toxicokinetics |
Toxicity Summary
Identification and Uses: 2-Methylaminoethanol is a viscous liquid used in the production of textile chemicals and pharmaceuticals. Human Exposure and Toxicity: One patient developed persistent hematuria, abnormal liver function, and multiple skin warts after exposure to 2-methylaminoethanol. Animal Studies: In rats, 2-methylaminoethanol is irritating to the skin, eyes, and mucous membranes. 150 ppm of 2-methylaminoethanol showed no maternal or embryotoxic effects in rats. Regardless of metabolic activation, 2-methylaminoethanol was not mutagenic to Salmonella Typhimurium TA 1535, TA 1537, TA 98, and TA 100. Non-Human Toxicity Values Oral LD50 in male rats: 1908 mg/kg; Oral LD50 in female rats: 1391 mg/kg; Dermal LD50 in male rabbits: 1880 mg/kg; Dermal LD50 in female rabbits: 1006 mg/kg. For more complete non-human toxicity data for 2-methylaminoethanol (out of 10), please visit the HSDB record page. 2-(Methylamino)ethanol is classified as a flammable liquid with a flash point of 130degF (approximately 54degC). It can produce toxic oxides of nitrogen during combustion. It may cause skin and eye irritation. Standard laboratory safety precautions should be followed, including use in a fume hood, avoiding ignition sources, and wearing appropriate PPE (gloves, goggles, lab coat). |
| Additional Infomation |
Methylethanolamine is a colorless, transparent liquid with a flash point of 165°F (74°C). It is less dense than water and readily soluble in water. Its vapor is heavier than air. Combustion produces toxic nitrogen oxides. It is used in the manufacture of other chemicals. N-Methylethanolamine is an ethanolamine compound with an N-methyl substituent. 2-(methylamino)ethanol has been reported in *Erythrophleum chlorostachys*, and relevant data are available.
2-(Methylamino)ethanol is a versatile chemical intermediate used in the synthesis of various pharmaceuticals, agrochemicals, and surfactants. The compound appears as a viscous, colorless to light yellow liquid. It is miscible with water and soluble in alcohol. The FDA has approved its use in certain applications (status: Unknown). This product is for research and industrial use only and is not intended for human therapeutic use. |
| Exact Mass |
75.068
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|---|---|
| CAS # |
109-83-1
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| PubChem CID |
8016
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| Appearance |
Colorless to light yellow liquid（Density：0.935 g/cm3）
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| Density |
0.9±0.1 g/cm3
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| Boiling Point |
159.9±13.0 °C at 760 mmHg
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| Melting Point |
23.9 °F (NTP, 1992)
; -3 °C
; -4.5 °C
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| Flash Point |
73.9±0.0 °C
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| Vapour Pressure |
0.9±0.6 mmHg at 25°C
|
| Index of Refraction |
1.44
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| LogP |
-0.96
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
5
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| Complexity |
16.4
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
OPKOKAMJFNKNAS-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C3H9NO/c1-4-2-3-5/h4-5H,2-3H2,1H3
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| Chemical Name |
2-(methylamino)ethanol
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| Synonyms |
2-Methylethanolamine; N-Methylethanolamine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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