| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
|
||
| Other Sizes |
| Targets |
Specific molecular target information for Cryptofolione is not provided in the search results. As a phenylpropanoid, it may have biological activities including antioxidant, anti-inflammatory, antimicrobial, and anticancer effects. Phenylpropanoids are known to modulate various signaling pathways including NF-kappaB, MAPK, and Nrf2. However, the specific mechanism of action and primary molecular target for Cryptofolione have not been characterized.
|
|---|---|
| ln Vitro |
Specific in vitro activity data for Cryptofolione is not provided in the search results. As a natural phenylpropanoid, it may exhibit various biological activities including DPPH radical scavenging (antioxidant), inhibition of LPS-induced NO production in macrophages (anti-inflammatory), or cytotoxicity against cancer cell lines. However, no IC50 values or detailed bioactivity data are reported. The compound is primarily used as an analytical reference standard for natural product research.
|
| ln Vivo |
Specific in vivo activity data for Cryptofolione is not provided in the search results. The compound has not been reported to be administered in animal models for efficacy studies. It is used as a research chemical for natural product isolation and characterization, not as a therapeutic agent. Its in vivo pharmacological profile remains uncharacterized.
|
| Enzyme Assay |
Not applicable. Cryptofolione is not used in cell-free binding assays. It is a natural product reference standard used in analytical chemistry for quality control and natural product research. Its characterization involves standard analytical methods such as HPLC, NMR, and MS to confirm identity and purity, not biological binding studies. The compound is stored as a powder at -20degC.
|
| Cell Assay |
Not applicable. Cryptofolione is a natural product standard used primarily in analytical chemistry, not for cell-based bioactivity assays. It is used as a reference standard for the quantification of phenylpropanoid compounds in plant extracts. If biological activity studies were to be performed, a general antioxidant assay (DPPH radical scavenging) or anti-inflammatory assay (LPS-stimulated NO production in RAW 264.7 macrophages) could be conducted. However, no such data is reported.
|
| Animal Protocol |
Not applicable. Cryptofolione is not used in animal studies as a test article. It is a reference standard for analytical applications. Any in vivo studies would involve the quantification of this compound in biological samples using the standard as a calibrator.
|
| ADME/Pharmacokinetics |
Specific pharmacokinetic data for Cryptofolione is not available. As a phenylpropanoid with a molecular weight of 256.30 g/mol, it may have moderate oral bioavailability. However, no ADME studies have been reported. Without such data, its absorption, distribution, metabolism, and excretion properties cannot be assessed.
|
| Toxicity/Toxicokinetics |
Specific toxicology data for Cryptofolione is not available. As a natural phenylpropanoid, it is presumed to have low toxicity at the concentrations used for analytical purposes. Standard laboratory safety precautions for handling organic compounds should be followed, including the use of gloves, lab coat, and safety goggles.
|
| Additional Infomation |
Cryptofolione is a natural product belonging to the class of phenylpropanoids, which are secondary metabolites derived from the amino acid phenylalanine. Phenylpropanoids are widely distributed in the plant kingdom and include important compounds such as cinnamic acid, coumarins, flavonoids, and lignans. Many phenylpropanoids possess significant biological activities including antioxidant, anti-inflammatory, antimicrobial, anticancer, and cardioprotective properties. Cryptofolione is primarily used as an analytical reference standard for the quality control of plant extracts and for natural product research. The compound is for research use only and is not an approved drug.
|
| Molecular Formula |
C19H22O4
|
|---|---|
| Molecular Weight |
314.38
|
| CAS # |
160098-78-2
|
| Appearance |
Typically exists as solids at room temperature
|
| LogP |
2.63
|
| SMILES |
O[C@H](C[C@H](/C=C/C1=CC=CC=C1)O)C/C=C/[C@]1(CC=CC(=O)O1)[H]
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1809 mL | 15.9043 mL | 31.8086 mL | |
| 5 mM | 0.6362 mL | 3.1809 mL | 6.3617 mL | |
| 10 mM | 0.3181 mL | 1.5904 mL | 3.1809 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
