| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| Other Sizes |
| Targets |
Specific target information for Kadsuric acid is not provided in the search results. As a triterpenoid compound isolated from Schisandra species, it may possess biological activities commonly associated with this class of natural products, including hepatoprotective, anti-inflammatory, and antioxidant effects [17L35]. However, its precise molecular target has not been identified. Triterpenoids from Schisandra are known to modulate liver function and protect against chemical-induced liver injury.
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|---|---|
| ln Vitro |
Specific in vitro activity data for Kadsuric acid is not provided in the search results. The compound is primarily used as an analytical reference standard for natural product research. As a triterpenoid, it may exhibit various biological activities including anti-inflammatory, hepatoprotective, or cytotoxic effects. However, no IC50 or EC50 values are reported. The compound has a purity of >98% and is stored as a powder [17L23-L25].
|
| ln Vivo |
Specific in vivo activity data for Kadsuric acid is not provided in the search results. The compound has not been reported to be administered in animal models for efficacy studies. It is used as a reference standard, not as a therapeutic agent. Its in vivo pharmacological profile remains uncharacterized.
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| Enzyme Assay |
Not applicable. Kadsuric acid is not used in cell-free binding assays. It is a natural product reference standard used in analytical chemistry for quality control and natural product research. Its characterization involves standard analytical methods such as HPLC, NMR, and MS to confirm identity and purity, not biological binding studies. The compound is stored as a powder at -20degC.
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| Cell Assay |
Not applicable. Kadsuric acid is not commonly tested in cell-based assays for biological activity. It is a natural product standard used primarily in analytical chemistry. If cytotoxicity studies were to be performed, a general protocol would involve treating cancer cell lines (e.g., HepG2, HeLa, MCF-7) with varying concentrations (1-100 uM) for 48-72 hours, followed by MTT or CellTiter-Glo assays. However, no such data is reported.
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| Animal Protocol |
Not applicable. Kadsuric acid is not used in animal studies as a test article. It is a reference standard for analytical applications. Any in vivo studies would involve the quantification of this compound in biological samples (e.g., plant extracts, plasma) using the standard as a calibrator.
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| ADME/Pharmacokinetics |
Specific pharmacokinetic data for Kadsuric acid is not available. As a triterpenoid with a molecular weight of 470.68 g/mol and two carboxylic acid groups, it is expected to have poor oral bioavailability due to low aqueous solubility and high molecular weight. Without such data, its absorption, distribution, metabolism, and excretion properties cannot be assessed.
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| Toxicity/Toxicokinetics |
Specific toxicology data for Kadsuric acid is not provided. As a natural triterpenoid, it is presumed to have low toxicity at the concentrations used for analytical purposes. Standard laboratory safety precautions for handling organic compounds should be followed, including the use of gloves, lab coat, and safety goggles.
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| Additional Infomation |
Reports indicate that safflower caldura contains caldura acid, and relevant data is available for reference.
Kadsuric acid (also known as South Schisandra Acid) is a triterpenoid natural product that can be isolated from the fruits of Schisandra sphenanthera (southern schisandra) and other plants including Kadsura coccinea and Piper kadsura [17L31-L33][17L23-L25]. Schisandra species have been used in traditional Chinese medicine for their hepatoprotective and adaptogenic properties. Kadsuric acid is an active triterpenoid constituent with a complex polycyclic structure featuring two carboxylic acid groups [17L4-L8]. The compound has a purity of >98% and is primarily used as an analytical reference standard for the quality control of Schisandra-containing herbal products. It is for research use only and is not an approved drug. |
| Molecular Formula |
C30H46O4
|
|---|---|
| Molecular Weight |
470.68
|
| Exact Mass |
470.34
|
| CAS # |
62393-88-8
|
| PubChem CID |
5384417
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| Appearance |
Typically exists as solids at room temperature
|
| Density |
1.1±0.1 g/cm3
|
| Boiling Point |
606.0±28.0 °C at 760 mmHg
|
| Flash Point |
334.3±20.5 °C
|
| Vapour Pressure |
0.0±3.7 mmHg at 25°C
|
| Index of Refraction |
1.54
|
| LogP |
9.57
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
9
|
| Heavy Atom Count |
34
|
| Complexity |
897
|
| Defined Atom Stereocenter Count |
6
|
| SMILES |
CC(CCC=C(C)C(=O)O)C1CCC2(C1(CC=C3C2CCC(C3(C)CCC(=O)O)C(=C)C)C)C
|
| InChi Key |
JGNPDWQZTUZFHK-LYNKRMMFSA-N
|
| InChi Code |
InChI=1S/C30H46O4/c1-19(2)22-11-12-25-24(28(22,5)16-15-26(31)32)14-18-29(6)23(13-17-30(25,29)7)20(3)9-8-10-21(4)27(33)34/h10,14,20,22-23,25H,1,8-9,11-13,15-18H2,2-7H3,(H,31,32)(H,33,34)/b21-10-/t20-,22+,23?,25-,28+,29-,30+/m1/s1
|
| Chemical Name |
(Z,6R)-6-[(3aR,6S,7S,9aS,9bS)-6-(2-carboxyethyl)-3a,6,9b-trimethyl-7-prop-1-en-2-yl-1,2,3,4,7,8,9,9a-octahydrocyclopenta[a]naphthalen-3-yl]-2-methylhept-2-enoic acid
|
| Synonyms |
Schisandra acid
|
| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1246 mL | 10.6229 mL | 21.2459 mL | |
| 5 mM | 0.4249 mL | 2.1246 mL | 4.2492 mL | |
| 10 mM | 0.2125 mL | 1.0623 mL | 2.1246 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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