| Size | Price | Stock | Qty |
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| 5g |
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| Other Sizes |
| Targets |
Perfluoroundecanoic acid is an orally active inducer of oxidative stress and DNA damage, exerting genotoxic and reproductive toxicity in Swiss mice. It is not a drug but an environmental contaminant and industrial chemical. It is known to activate the peroxisome proliferator-activated receptor alpha (PPARalpha) and may disrupt endocrine function. Its "target" in toxicology studies includes the liver, testis, and other organs.
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| ln Vitro |
Perfluoroundecanoic acid induces oxidative stress and DNA damage in vitro, although specific IC50 values are not provided. In Swiss mice, it exerts genotoxic and reproductive toxicity. It is known to be toxic to the liver and has been associated with reproductive and developmental toxicity in animal studies. It is used as a standard in analytical chemistry to monitor environmental and biological samples.
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| ln Vivo |
Perfluoroundecanoic acid is an orally active toxicant in animals. In Swiss mice, it exerts genotoxic effects and reproductive toxicity. Chronic exposure to perfluorinated compounds (PFCs) has been linked to liver toxicity, immune suppression, and developmental effects in various animal models. PFUnDA, as a long-chain PFC, is known to persist in the body and cause bioaccumulation.
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| Enzyme Assay |
Not applicable. Perfluoroundecanoic acid is not used in cell-free enzyme assays as a substrate or inhibitor. It is an industrial chemical and environmental contaminant. Its activity is assessed in vivo or in cell culture systems. For analytical purposes, it is quantified by LC-MS/MS. For receptor binding studies, it can be used to assess PPARalpha activation using a reporter gene assay.
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| Cell Assay |
The toxicological effects of Perfluoroundecanoic acid can be assessed in hepatocytes. Procedure: Primary mouse hepatocytes are isolated via collagenase perfusion and seeded in 6-well plates (1×10⁶ cells/well). Cells are treated with varying concentrations of Perfluoroundecanoic acid (1-500 uM) for 24-48 hours. Cellular reactive oxygen species (ROS) levels are measured using DCFH-DA fluorescent dye. DNA damage is assessed by the comet assay (single-cell gel electrophoresis). Cell viability is measured by MTT assay. The EC50 for cytotoxicity or ROS induction is calculated.
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| Animal Protocol |
The in vivo toxicity of Perfluoroundecanoic acid can be evaluated in a mouse model. Procedure: Male Swiss mice (8 weeks, n=10 per group) are administered Perfluoroundecanoic acid orally (gavage) at doses of 0, 10, 50, and 100 mg/kg daily for 28 days. Control animals receive vehicle (e.g., 0.5% Tween-80 in water). Body weight and food intake are monitored weekly. At the end of the study, mice are euthanized, and blood is collected for serum chemistry (ALT, AST, creatinine). Liver, testis, and kidney are harvested for histological analysis (H&E staining). Sperm count and morphology are assessed for reproductive toxicity. Micronucleus test is performed on bone marrow smears to assess genotoxicity.
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| ADME/Pharmacokinetics |
Perfluoroundecanoic acid is orally active and known to bioaccumulate. In animal studies, it has a long half-life (weeks to months) and is distributed primarily to the liver, kidneys, and blood. It is not extensively metabolized and is excreted mainly in urine and feces. Due to its persistence, it accumulates in the body over time.
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| Toxicity/Toxicokinetics |
Perfluoroundecanoic acid is toxic and has been shown to induce oxidative stress, DNA damage, genotoxicity, and reproductive toxicity in mice. It is classified as a hazardous substance and can cause liver injury, developmental toxicity, and endocrine disruption. Due to its environmental persistence and bioaccumulation, it is a pollutant of concern. Perfluoroundecanoic acid is for research use only and is not a drug.
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| References | |
| Additional Infomation |
Perfluoroundecanoic acid is a fluoroalkyl acid, specifically perfluorinated undecanoic acid. It is an exogenous substance and environmental pollutant whose function is related to undecanoic acid. Perfluoroundecanoic acid belongs to the perfluoroalkyl acids (PFAAs). PFAAs are frequently detected in the environment, plants, fish, and animals. They are decomposition products of stain- and oil-resistant coatings on food packaging, sofas, carpets, and other surfaces. Like many PFAAs, it is persistent and bioaccumulative. PFAAs are considered endocrine disruptors, and many are known toxins and carcinogens. PFAAs have been used in the manufacture of well-known consumer products such as Teflon and Gore-Tex.
Perfluoroundecanoic acid (PFUnDA) is a perfluoroalkyl carboxylic acid (PFCA) belonging to the class of per- and polyfluoroalkyl substances (PFAS). It is used as a processing aid in the manufacture of fluoropolymers and has been detected in the environment as a persistent contaminant. PFUnDA is known to be toxic and has been shown to induce oxidative stress, DNA damage, genotoxicity, and reproductive toxicity. It is used as a reference standard for environmental and toxicological analysis. This product is for research use only. |
| Molecular Formula |
C11HF21O2
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|---|---|
| Molecular Weight |
564.09
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| Exact Mass |
563.964
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| CAS # |
2058-94-8
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| PubChem CID |
77222
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| Appearance |
White to off-white solid powder
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| Density |
1.764g/cm3
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| Boiling Point |
229.5ºC at 760 mmHg ,160ºC60 mm Hg(lit.)
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| Melting Point |
96-101ºC(lit.)
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| Flash Point |
92.6ºC
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| Vapour Pressure |
0.0247mmHg at 25°C
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| Index of Refraction |
1.288
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| LogP |
6.351
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
23
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| Rotatable Bond Count |
9
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| Heavy Atom Count |
34
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| Complexity |
789
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| Defined Atom Stereocenter Count |
0
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| SMILES |
FC(C(C(C(C(C(=O)O[H])(F)F)(F)F)(F)F)(F)F)(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)F
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| InChi Key |
SIDINRCMMRKXGQ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C11HF21O2/c12-2(13,1(33)34)3(14,15)4(16,17)5(18,19)6(20,21)7(22,23)8(24,25)9(26,27)10(28,29)11(30,31)32/h(H,33,34)
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| Chemical Name |
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-henicosafluoroundecanoic acid
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| Synonyms |
Perfluoroundecanoic acid; Heneicofluoroundecanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7728 mL | 8.8638 mL | 17.7277 mL | |
| 5 mM | 0.3546 mL | 1.7728 mL | 3.5455 mL | |
| 10 mM | 0.1773 mL | 0.8864 mL | 1.7728 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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