| Size | Price | Stock | Qty |
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| 250mg |
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| 500mg |
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| 50g |
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| 100g |
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| 500g |
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| Other Sizes |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
This substance can enter the body through inhalation and ingestion. Animal experiments…high doses…cyclohexanol is readily absorbed through the skin…after oral administration…the compound in rabbits was excreted in the urine as a sulfate and glucuronic acid conjugate. Similar results were obtained after repeated inhalation of the compound in animals. …Rabbits exposed to the lowest concentration (145 ppm) of cyclohexanol in the air did not show an increase in sulfate conjugates in their urine, but glucuronic acid excretion was 5 times the normal value. …The increase in urinary glucuronic acid paralleled the decrease in the percentage of inorganic sulfate. …The proportion of sulfate in the urine returned to normal after cessation of exposure…leading to the conclusion that this substance does not remain in the body for a long time. Metabolism / Metabolites In the presence of NADPH and oxygen, cyclohexane is hydroxylated to cyclohexanol in rat liver microsomes. Pretreatment with intraperitoneal phenobarbital (80 mg/kg/day) increased hydroxylation activity by 6-fold, while pretreatment with intraperitoneal benzo[a]pyrene (20 mg/kg) decreased cyclohexane hydroxylation activity. In rats, rabbits, and guinea pigs (oral or intraperitoneal, doses 50–500 mg/kg) and humans (oral, doses 25 or 200 mg), urinary metabolites following administration of cyclohexylamine hydrochloride were identified as cyclohexanol. In rabbits, cyclohexanol was primarily excreted as glucuronide conjugates (60% of dose), but a small amount was further oxidized to transcyclohexane-1,2-diol (6%). Hepatic NAD-dependent alcohol dehydrogenases…are responsible for metabolizing…cyclohexanol…For more complete data on the metabolism/metabolites of cyclohexanol (8 in total), please visit the HSDB record page. Biological Half-Life No relevant report found; [TDR, page 430] |
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| Toxicity/Toxicokinetics |
Interactions
This study investigated the acute effects of ethanol (EtOH) on the urinary excretion of cyclohexanol (CH-ol), 1,2-cyclohexanediol, and 1,4-cyclohexanediol (CH-diol), important biomarkers of solvent exposure and chemical intermediates such as cyclohexanone (CH-one), cyclohexane (CH), and cyclohexanol. Volunteers (5–8 per group) were exposed to CH-one, CH, or CH-ol vapors at concentrations of approximately 200, 1000, and (standard reference concentration: 2000) mg/m³ for 8 hours, while simultaneously ingesting ethanol (4 doses of 14 g each during the exposure period). Urine was collected over 72 hours, and the CH-ol and CH-diol levels were analyzed. Results: In the ethanol exposure group, the metabolic yields of CH-ol, 1,2-, and 1,4-CH-diol were 11.3%, 36%, and 23% after CH-one exposure; 3.1%, 15%, and 8% after CH exposure; and 6.6%, 24%, and 18% after CH-ol exposure. [The corresponding values obtained in the previous ethanol-free control were: 1.0%, 39%, and 18% for CH-one; 0.5%, 23%, and 11% for CH; and 1.1%, 19%, and 8% for CH-ol.] The excretion curves of the metabolites in the ethanol exposure group were not delayed compared to the corresponding curves in the control group. Conclusion: The urinary excretion of CH-diol is much less sensitive to ethanol than that of CH-ol. It is recommended that CH-diol be used as a useful and more reliable biomarker for exposure to CH-one, CH, and CH-ol in field investigations. Non-Human Toxicity Values Oral LD50 in rats: 2060 mg/kg; Oral (gavage) LD50 in rats: 1550 mg/kg; Intraperitoneal LD50 in mice: 1352 mg/kg; Subcutaneous LD50 in mice: 2480 mg/kg. For more complete non-human toxicity data on cyclohexanol (8 types), please visit the HSDB record page. Toxicity Data LC (rat) > 6,500 mg/m3/1h (inhalation) |
| Additional Infomation |
Cyclohexanol is a colorless liquid with a camphor-like odor. It is soluble in most organic liquids. Its flash point is 57°C (154°F). Inhalation or skin contact may cause poisoning. High concentrations of vapor have anesthetic effects. It irritates the skin, eyes, and mucous membranes. It is used in the manufacture of soaps, varnishes, and plastics. Cyclohexanol is an alcohol composed of a cyclohexane molecule linked to a single hydroxyl substituent. It is the parent compound of cyclohexanols. It can be used as a solvent. It is a member of the cyclohexanol class and is also a secondary alcohol. Cyclohexanol has been reported to be found in pomegranate (Punica granatum), upland cotton (Gossypium hirsutum), and mango (Mangifera indica), and there is relevant data available. Cyclohexanol is a monohydroxy derivative of cyclohexane containing the general formula R-C6H11O. They have a camphor-like odor and are used in the manufacture of soaps, insecticides, fungicides, dry cleaning agents, and plasticizers. Cyclohexanol is a metabolite found or produced in Saccharomyces cerevisiae. View other related relationships...
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| Molecular Formula |
C6H12O
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|---|---|
| Molecular Weight |
100.16
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| Exact Mass |
100.089
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| CAS # |
108-93-0
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| PubChem CID |
7966
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| Appearance |
Liquid（0.948 g/cm3） ; Colorless to light yellow
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
159.6±8.0 °C at 760 mmHg
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| Melting Point |
73 °F (NTP, 1992)
; 25.93 °C
; 23 °C
; 77 °F
; 24 °C
; 77 °F
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| Flash Point |
67.8±0.0 °C
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| Vapour Pressure |
0.9±0.6 mmHg at 25°C
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| Index of Refraction |
1.478
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| LogP |
1.34
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
7
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| Complexity |
46.1
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C1CCC(CC1)O
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| InChi Key |
HPXRVTGHNJAIIH-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H12O/c7-6-4-2-1-3-5-6/h6-7H,1-5H2
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| Chemical Name |
cyclohexanol
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| Synonyms |
Hydroxycyclohexane;NSC 54711;Naxol;Cyclohexanol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 9.9840 mL | 49.9201 mL | 99.8403 mL | |
| 5 mM | 1.9968 mL | 9.9840 mL | 19.9681 mL | |
| 10 mM | 0.9984 mL | 4.9920 mL | 9.9840 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Link: https://clinicaltrials.gov/ct2/show/NCT05255107
Conditions:Keratitis|Corneal UlcerLink: https://clinicaltrials.gov/ct2/show/NCT01708538
Conditions:Corneal Ectasia Disorders Including KeratoconusLink: https://clinicaltrials.gov/ct2/show/NCT01789528
Conditions:Pharmacokinetics|Open Label|CAZ-AVI|CXL|Effect on Intestinal Flora|SafetyProducts are for research use only; We do not sell to patients
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