| Size | Price | Stock | Qty |
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| 1mg |
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| Other Sizes |
| Targets |
The specific molecular target of delta-Cadinol is not well-defined. However, research indicates it exhibits biological activity by interacting with microbial cells and potentially binding to FAD-dependent oxidases. Studies have shown that it exhibits antimicrobial, trypanocidal, anti-inflammatory, and cytotoxic activities. It is associated with the major components of essential oils from plants like Kadsura longipedunculata. The exact mechanism of action is not fully elucidated, but it is an epimer of alpha-cadinol.
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| ln Vitro |
In vitro, delta-Cadinol has been shown to exhibit antimicrobial activity against various Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis, as well as anti-inflammatory and cytotoxic activity. It is one of the active compounds in essential oils that demonstrates cytotoxicity against human cancer cell lines, though its specific potency is often studied in combination with other sesquiterpenes. It also exhibits some degree of trypanocidal activity.
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| ln Vivo |
Specific in vivo activity data for pure delta-Cadinol is less commonly reported. However, it is a known component of essential oils that exhibit in vivo biological effects. As a plant metabolite and volatile oil component, it is considered to possess allelopathic and antimicrobial properties in its natural ecological context. Its role as a metabolite in organisms like Vitis vinifera suggests it plays a role in the plant's defense system, but detailed in vivo pharmacological studies are limited.
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| Enzyme Assay |
No detailed protocols are available for receptor binding studies. As an uncharacterized natural product, preliminary binding can be studied using computational docking to predict interactions with proteins like FAD-dependent NAD(P)H oxidases. For direct biochemical assays, the compound's activity is often inferred from its presence in complex mixtures, and its mechanism is assumed to involve membrane disruption or interaction with microbial cell components, but specific binding assays are not standard for this compound.
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| Cell Assay |
For in vitro assays, cells (e.g., human cancer cell lines or Gram-positive bacteria such as S. aureus) are typically cultured in appropriate media. delta-Cadinol is dissolved in DMSO and added to the culture at various concentrations (e.g., 25-200 ug/mL). Cytotoxicity is measured after 24-72 hours using standard assays like MTT or SRB. Antimicrobial activity is assessed by measuring the minimum inhibitory concentration (MIC) and zone of inhibition. These assays are often performed on crude essential oils containing delta-cadinol.
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| Animal Protocol |
In vivo studies for delta-Cadinol are not standard for isolated compound. If required, typical allelopathy studies involve applying the compound to plant seeds (e.g., lettuce) and measuring germination and growth inhibition. For antimicrobial studies, an animal model (e.g., mouse skin infection model) could be used. The compound would be formulated in a suitable vehicle and applied topically or injected. However, such specific protocols are not documented in general public sources for this isolated compound.
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| ADME/Pharmacokinetics |
No specific pharmacokinetic data for delta-Cadinol is available in general sources. As a sesquiterpenoid with a molecular weight of 222.37 and a predicted LogP around 3-4, it is expected to be lipophilic, well-absorbed, and able to cross cell membranes. It is soluble in organic solvents such as isopropyl ether, ethanol, and DMSO, but has poor water solubility. It is likely metabolized by cytochrome P450 enzymes in the liver. For experimental use, it is typically stored as a powder at -20degC and protected from light.
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| Toxicity/Toxicokinetics |
Specific toxicology data for delta-Cadinol is not available. As a plant-derived natural product, it is generally regarded with low acute toxicity, but it should be treated as a potential irritant. The compound is likely a skin, eye, and respiratory tract irritant. Standard laboratory safety precautions should be followed, including use in a fume hood and wearing personal protective equipment (gloves, lab coat, goggles). Avoid ingestion, inhalation, and skin contact. The compound is not for human use and is strictly a research chemical.
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| References | |
| Additional Infomation |
(-)-δ-carbidol is a carbidane sesquiterpene compound composed of 1,6-dimethyl-4-(propyl-2-yl)-1,2,3,4,4a,7,8,8a-octahydronaphthalene with a hydroxyl substituent at position 1, and a configuration of (1R,4S,4aR,8aS). It is a metabolite found in both algae and plants. It is a carbidane sesquiterpene compound, belonging to the octahydronaphthalene class, and is also a tertiary alcohol. It is the enantiomer of (+)-δ-carbidol. δ-carbidol has been reported in hops (Humulus lupulus), ginger (Alpinia latilabris), and other organisms with available data.
delta-Cadinol is a natural product with reported antimicrobial, anti-inflammatory, and cytotoxic activities. It is isolated from various plants and is used as a chemical standard for natural product research. The compound has no approved clinical or therapeutic use and is strictly for laboratory research purposes. No information on clinical trials or regulatory approval is available. |
| Molecular Formula |
C15H26O
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|---|---|
| Molecular Weight |
222.37
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| Exact Mass |
222.198
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| CAS # |
19435-97-3
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| PubChem CID |
3084311
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| Appearance |
White to off-white solid powder
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| Density |
0.937g/cm3
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| Boiling Point |
303.4ºC at 760 mmHg
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| Flash Point |
128.3ºC
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| Vapour Pressure |
8.96E-05mmHg at 25°C
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| Index of Refraction |
1.489
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| LogP |
3.775
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
16
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| Complexity |
292
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| Defined Atom Stereocenter Count |
4
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| SMILES |
CC1=C[C@H]2[C@@H](CC[C@@]([C@H]2CC1)(C)O)C(C)C
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| InChi Key |
LHYHMMRYTDARSZ-ZQDZILKHSA-N
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| InChi Code |
InChI=1S/C15H26O/c1-10(2)12-7-8-15(4,16)14-6-5-11(3)9-13(12)14/h9-10,12-14,16H,5-8H2,1-4H3/t12-,13-,14-,15+/m0/s1
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| Chemical Name |
(1R,4S,4aR,8aS)-1,6-dimethyl-4-propan-2-yl-3,4,4a,7,8,8a-hexahydro-2H-naphthalen-1-ol
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| Synonyms |
(-)-Torreyol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.4970 mL | 22.4850 mL | 44.9701 mL | |
| 5 mM | 0.8994 mL | 4.4970 mL | 8.9940 mL | |
| 10 mM | 0.4497 mL | 2.2485 mL | 4.4970 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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