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| Other Sizes |
| Toxicity/Toxicokinetics |
Toxicity Summary
Identification and Uses: Phthalate (OPA) is used as a disinfectant and a reagent for the fluorescence determination of primary amines and thiols. Human Studies: OPA is a commonly used rapid disinfectant solution for medical devices. Anaphylactic shock has been reported after cystoscopy using endoscopes disinfected with this disinfectant. OPA-induced anaphylactic shock has also been reported after laryngoscopy. OPA-specific IgE was detected in the serum of these patients. Four staff members in the endoscopy unit developed contact dermatitis, one of whom also developed asthma. In 80 female disinfection staff members who used OPA-containing disinfectants only, the incidence of disinfection-related adverse reactions was: skin symptoms 10%, ocular symptoms 9%, and respiratory symptoms 16%. Animal Studies: In male mice, injection of phthalic acid (OPA) induced the production of specific IgE and IgG in serum, indicating that OPA may function as a hapten. Overall, OPA can induce acute inflammation and act as a hapten allergen, but causes only mild liver damage. In ovalbumin (OVA)-sensitized mice, OPA enhances OVA-induced neutrophil recruitment to the lungs and the production of allergen-specific IgE, suggesting that OPA may function as an immune adjuvant. Major target organs after OPA exposure in rats and mice include the respiratory system (nasal cavity, larynx, trachea, and lungs), skin, eyes, testes, and epididymis. In male and female rats and mice, the most sensitive indicator of OPA inhalation toxicity was a significantly increased incidence of nasal lesions (lowest observable concentration = 0.44 ppm). OPA is mutagenic to Salmonella typhimurium TA100 strain in the absence of exogenous metabolic activation; no mutagenicity was observed in metabolically activated TA100 strains, or in metabolically activated TA98 strains or Escherichia coli WP2 uvrA/pKM101 strains with or without metabolic activation. |
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| References | |
| Additional Infomation |
Phthalate is a dialdehyde with two formyl groups attached to adjacent carbon atoms on its benzene ring. It is an epitope. It belongs to the benzaldehyde family of compounds. It is a reagent that can form fluorescently coupled products with primary amines. It is used to detect nanograms of various biogenic amines, peptides, and proteins in bodily fluids.
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| Molecular Formula |
C8H6O2
|
|---|---|
| Molecular Weight |
134.13
|
| Exact Mass |
134.036
|
| CAS # |
643-79-8
|
| Related CAS # |
25750-62-3
|
| PubChem CID |
4807
|
| Appearance |
Long, pale yellow needles from petroleum ether (MP 56-56.5 °C). Also reported as colorless powder (MP: 54 °C)
Yellow needles or crystals from ligroin |
| Density |
1.2±0.1 g/cm3
|
| Boiling Point |
266.1±23.0 °C at 760 mmHg
|
| Melting Point |
55-58 °C(lit.)
|
| Flash Point |
98.5±19.6 °C
|
| Vapour Pressure |
0.0±0.5 mmHg at 25°C
|
| Index of Refraction |
1.623
|
| LogP |
0.51
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
10
|
| Complexity |
115
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O=C([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])=O
|
| InChi Key |
ZWLUXSQADUDCSB-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C8H6O2/c9-5-7-3-1-2-4-8(7)6-10/h1-6H
|
| Chemical Name |
phthalaldehyde
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| Synonyms |
Phthaldialdehyde
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : 200 mg/mL (1491.09 mM; with sonication)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.4555 mL | 37.2773 mL | 74.5545 mL | |
| 5 mM | 1.4911 mL | 7.4555 mL | 14.9109 mL | |
| 10 mM | 0.7455 mL | 3.7277 mL | 7.4555 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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