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| Other Sizes |
| Targets |
N-Phthaloylglycine does not target a specific biological receptor but serves as a chemical intermediate and protected amino acid derivative. The phthaloyl group protects the amino group of glycine during peptide synthesis or other organic reactions. The carboxylic acid group can be activated for coupling reactions, making it a versatile building block for the synthesis of more complex molecules, including pharmaceuticals and biologically active compounds.
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| ln Vitro |
In vitro, N-Phthaloylglycine is used as a starting material or intermediate in organic synthesis. It can be deprotected to yield glycine or further functionalized at the carboxylic acid group. The compound's role is as a chemical reagent rather than a biologically active compound. Its utility in vitro is in the context of chemical synthesis, not in biological assays or cell-based experiments.
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| ln Vivo |
In vivo activity is not applicable for N-Phthaloylglycine, as it is a chemical intermediate and not a therapeutic compound. The compound is not designed or intended for administration to living organisms. Its primary use is in the synthesis of pharmaceuticals and other organic compounds. Any in vivo effects would be related to the final pharmaceutical products synthesized from this intermediate.
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| Enzyme Assay |
Non-cellular assays for N-Phthaloylglycine are not applicable as the compound is not a biologically active agent but a chemical intermediate. Its characterization involves standard chemical analysis including melting point determination (193-196°C), NMR spectroscopy, HPLC for purity assessment, and mass spectrometry for molecular weight confirmation. The compound's solubility in water is very high, and it has a density of 1.3849.
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| Cell Assay |
In vitro cellular experiments are not applicable for N-Phthaloylglycine as it is a chemical intermediate used in organic synthesis, not a compound tested on cells. Its role is in the preparation of other compounds that may subsequently be evaluated in biological assays. Researchers using this compound for synthesis should follow standard laboratory safety practices for handling organic chemicals.
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| Animal Protocol |
In vivo animal experiments are not conducted with N-Phthaloylglycine, as the compound is a chemical reagent and intermediate, not a therapeutic candidate. The compound is used in the synthesis of pharmaceuticals that may later be tested in animals, but the intermediate itself is not administered.
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| ADME/Pharmacokinetics |
N-Phthaloylglycine has a molecular formula of C10H7NO4 and a molecular weight of 205.17 g/mol. The CAS number is 4702-13-0. It has a melting point of 193-196°C and a boiling point of approximately 343.83°C. The compound is very soluble in water. It is typically stored at room temperature and has a shelf life of several years when kept dry. Purity is available at ≥98%.
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| Toxicity/Toxicokinetics |
Toxicity data for N-Phthaloylglycine are typical of organic chemicals. The compound is a phthalimide derivative and should be handled with appropriate personal protective equipment. Standard laboratory safety precautions should be followed when handling this compound. The compound is for research use only and is not intended for human therapeutic applications.
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| References | |
| Additional Infomation |
N-Phthaloylglycine is also known as Phthaloyl glycine and 2-(1,3-dioxoisoindolin-2-yl)acetic acid. The EINECS number is 225-177-3. It is available at 98+% purity from various chemical suppliers. The compound is commonly used as a pharmaceutical intermediate and in peptide synthesis. All products are for research use only.
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| Molecular Formula |
C10H7NO4
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|---|---|
| Molecular Weight |
205.17
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| Exact Mass |
205.037
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| CAS # |
4702-13-0
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| PubChem CID |
20825
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| Appearance |
White to off-white solid powder
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| Density |
1.5±0.1 g/cm3
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| Boiling Point |
412.6±28.0 °C at 760 mmHg
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| Melting Point |
193-196 °C(lit.)
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| Flash Point |
203.3±24.0 °C
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| Vapour Pressure |
0.0±1.0 mmHg at 25°C
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| Index of Refraction |
1.640
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| LogP |
1.19
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
15
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| Complexity |
301
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C1C2=C([H])C([H])=C([H])C([H])=C2C(N1C([H])([H])C(=O)O[H])=O
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| InChi Key |
WQINSVOOIJDOLJ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C10H7NO4/c12-8(13)5-11-9(14)6-3-1-2-4-7(6)10(11)15/h1-4H,5H2,(H,12,13)
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| Chemical Name |
2-(1,3-dioxoisoindol-2-yl)acetic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
Typically soluble in DMSO (e.g. 10 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.8740 mL | 24.3700 mL | 48.7401 mL | |
| 5 mM | 0.9748 mL | 4.8740 mL | 9.7480 mL | |
| 10 mM | 0.4874 mL | 2.4370 mL | 4.8740 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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