| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Lophine does not have a specific biological target in the traditional sense, as it is primarily used as a chemical intermediate and fluorescent material. However, as a multi-substituted imidazole, its core structure is a privileged scaffold in medicinal chemistry, and derivatives can interact with various biological targets such as protein kinases.
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|---|---|
| ln Vitro |
In vitro, Lophine's primary activity is its fluorescence, which is utilized in materials science and optical applications. Its biological activity is not typically evaluated, but it serves as a building block for compounds with potential biological activities.
|
| ln Vivo |
In vivo activity is not applicable to Lophine, as it is a chemical intermediate and not a pharmacologically active compound.
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| Enzyme Assay |
In vitro enzyme or receptor binding assay protocols are not applicable to Lophine. It is characterized by its photophysical properties, such as absorption and emission spectra.
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| Cell Assay |
In vitro cell-based assay protocols are not applicable to Lophine. It is not used in cell-based studies for its biological effects.
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| Animal Protocol |
In vivo animal experimental protocols are not applicable to Lophine.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties are not applicable to Lophine. It is a solid at room temperature.
|
| Toxicity/Toxicokinetics |
Toxicological data for Lophine are limited. As a research chemical, it should be handled with standard laboratory safety precautions.
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| References | |
| Additional Infomation |
Lophine (2,4,5-Triphenylimidazole) is a research-grade chemical used primarily as a building block in organic synthesis and for its fluorescent properties in materials science. It is also a precursor for the synthesis of various pharmacologically active compounds. It has no clinical applications and is not a drug.
|
| Molecular Formula |
C21H16N2
|
|---|---|
| Molecular Weight |
296.37
|
| Exact Mass |
296.131
|
| CAS # |
484-47-9
|
| PubChem CID |
10232
|
| Appearance |
Solid powder
|
| Density |
1.2±0.1 g/cm3
|
| Boiling Point |
508.6±19.0 °C at 760 mmHg
|
| Melting Point |
274-278 °C(lit.)
|
| Flash Point |
272.6±7.9 °C
|
| Vapour Pressure |
0.0±1.3 mmHg at 25°C
|
| Index of Refraction |
1.640
|
| LogP |
6.82
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
3
|
| Heavy Atom Count |
23
|
| Complexity |
351
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
N1([H])C(C2C([H])=C([H])C([H])=C([H])C=2[H])=NC(C2C([H])=C([H])C([H])=C([H])C=2[H])=C1C1C([H])=C([H])C([H])=C([H])C=1[H]
|
| InChi Key |
RNIPJYFZGXJSDD-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C21H16N2/c1-4-10-16(11-5-1)19-20(17-12-6-2-7-13-17)23-21(22-19)18-14-8-3-9-15-18/h1-15H,(H,22,23)
|
| Chemical Name |
2,4,5-triphenyl-1H-imidazole
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
Typically soluble in DMSO (e.g. 10 mM)
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3742 mL | 16.8708 mL | 33.7416 mL | |
| 5 mM | 0.6748 mL | 3.3742 mL | 6.7483 mL | |
| 10 mM | 0.3374 mL | 1.6871 mL | 3.3742 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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