| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
2-Quinoxalinol does not have a specific biological target. It is a small molecule that can interact with various compounds, such as antioxidant vitamins and aromatic metabolites, including neurotransmitters and melatonin. Its photocatalytic activity suggests it can participate in light-driven chemical reactions. As a heterocyclic compound, it may also interact with biological molecules through various non-covalent interactions. The compound's interactions with neurotransmitters and melatonin make it of interest for neurochemical research.
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|---|---|
| ln Vitro |
In vitro, 2-Quinoxalinol is used as a research tool to study its photocatalytic activity and its interactions with various compounds. Its activity is typically assessed in chemical assays measuring its ability to participate in photochemical reactions or to interact with target molecules. As a heterocyclic compound, it may also be used as a building block in organic synthesis.
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| ln Vivo |
In vivo activity data for 2-Quinoxalinol are not available in the current scientific literature, as it is primarily a research chemical for in vitro studies.
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| Enzyme Assay |
In vitro assays for 2-Quinoxalinol involve studying its photocatalytic properties or its interactions with other molecules. Its interactions with neurotransmitters or melatonin can be assessed using spectroscopic or electrochemical methods.
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| Cell Assay |
2-Quinoxalinol is not typically used in cell-based assays.
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| Animal Protocol |
2-Quinoxalinol is not used in animal studies.
|
| ADME/Pharmacokinetics |
2-Quinoxalinol has a molecular weight of 146.15. It is a research chemical and its pharmacokinetic properties are not relevant.
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| References | |
| Additional Infomation |
Quinoxalo-2-ol is a hydroxyquinoxalool, formed by introducing a hydroxyl substituent at the 2-position of the quinoxalool molecule. It is a metabolite derived from the hydride of quinoxalool.
2-Quinoxalinol (Quinoxalin-2-one) is a research-grade heterocyclic compound with photocatalytic activity. It interacts with various compounds, including neurotransmitters and melatonin. It has not entered clinical trials and is not approved for any therapeutic indication. Its mechanism of action is chemical, involving photocatalytic and interaction properties. The compound is available for research purposes. |
| Molecular Formula |
C8H6N2O
|
|---|---|
| Molecular Weight |
146.14604
|
| Exact Mass |
146.048
|
| CAS # |
1196-57-2
|
| PubChem CID |
14526
|
| Appearance |
Off-white to light brown solid powder
|
| Density |
1.3±0.1 g/cm3
|
| Boiling Point |
363.4±22.0 °C at 760 mmHg
|
| Melting Point |
271-272°C
|
| Flash Point |
173.6±22.3 °C
|
| Vapour Pressure |
0.0±0.8 mmHg at 25°C
|
| Index of Refraction |
1.705
|
| LogP |
0.8
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
0
|
| Heavy Atom Count |
11
|
| Complexity |
200
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O=C1NC2=CC=CC=C2N=C1
|
| InChi Key |
FFRYUAVNPBUEIC-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C8H6N2O/c11-8-5-9-6-3-1-2-4-7(6)10-8/h1-5H,(H,10,11)
|
| Chemical Name |
1H-quinoxalin-2-one
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
Typically soluble in DMSO (e.g. 10 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.8423 mL | 34.2114 mL | 68.4229 mL | |
| 5 mM | 1.3685 mL | 6.8423 mL | 13.6846 mL | |
| 10 mM | 0.6842 mL | 3.4211 mL | 6.8423 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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