| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
| Targets |
This compound does not target a specific biological receptor. It is a chemical excipient and a nutritional source. Its primary mechanism is metabolic, as it is rapidly absorbed from the gut, transported directly to the liver via the portal vein, and undergoes beta-oxidation to generate ketone bodies (acetoacetate and beta-hydroxybutyrate) which serve as an efficient energy source.
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| ln Vitro |
MCTs are rapidly absorbed and metabolized, providing a quick source of ATP. In biochemical experiments, they serve as a non-toxic control for long-chain fatty acids to study lipid metabolism. Unlike long-chain triglycerides (LCTs), they do not require incorporation into chylomicrons for transport, making them useful for inducing ketosis without affecting cholesteryl ester metabolism.
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| ln Vivo |
Not available. As a nutritional supplement and excipient, the compound itself has no specific in vivo activity as a drug. However, dietary MCTs are used in the clinical management of epilepsy as part of the ketogenic diet, and they are known to improve cognitive function and reduce amyloid-beta accumulation in animal models of Alzheimer's disease.
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| Enzyme Assay |
Not applicable. As a solvent or a mixture of natural fatty acids, it does not interact with a specific receptor in a lock-and-key manner.
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| Cell Assay |
Not applicable. As a solvent and a control, it is not used to stimulate a biological pathway. It may be used as a component of a cell culture medium at specific concentrations for studies on cellular metabolism, but it is not typically a test article in a biological activity experiment.
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| Animal Protocol |
For in vivo studies, the compound is typically administered directly to animals by oral gavage, or mixed into their diet at defined percentages (e.g., 20-40% of total calories). It is used as a solvent in in vivo formulation preparation. For example, in a typical co-solvent system, 900 uL of MCT oil can be mixed with 100 uL of a DMSO stock solution of a hydrophobic drug to prepare a solution for intraperitoneal (IP) or intravenous (IV) injection.
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| ADME/Pharmacokinetics |
As a triglyceride, it is rapidly metabolized to caprylic and caproic acid, which are further broken down to carbon dioxide and water. Its use as a solvent can alter the pharmacokinetics (absorption, distribution) of a co-administered active drug by affecting its solubility and stability.
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| Toxicity/Toxicokinetics |
MCTs are generally recognized as safe (GRAS) as a food additive and are well-tolerated at typical doses used in research. Overconsumption can lead to gastrointestinal distress, including diarrhea, due to the rapid osmotic load. No specific toxicology studies are reported, as it is considered a benign material.
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| Additional Infomation |
Mid-chain triglyceride of caprylic/caprolic acid is a research-grade biochemical and a common pharmaceutical excipient. It is not a drug and is not intended for any therapeutic use. It is widely used as a co-solvent in the formulation of poorly soluble compounds for in vivo animal studies, and as a control or source of energy in metabolic research. It is also the primary component of commercial MCT oil products used as dietary supplements.
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| Appearance |
Colorless to light yellow liquid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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