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| Other Sizes |
| Targets |
Hordenine hydrochloride inhibits melanogenesis by suppressing cAMP production. As an alkaloid, it may also have other biological activities including potential antibiotic effects.
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| ln Vitro |
In vitro, Hordenine hydrochloride inhibits melanin production by inhibiting the production of cAMP. This mechanism underlies its potential use in skin depigmentation research and cosmetic applications.
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| ln Vivo |
In vivo activity data for Hordenine hydrochloride are limited. As an alkaloid found in plants, it may have various pharmacological effects, but specific in vivo studies have not been extensively reported.
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| Enzyme Assay |
For non-cellular in vitro assays, Hordenine hydrochloride is evaluated for its inhibition of cAMP production. Biochemical assays measuring cAMP levels in cell-free systems may be used to confirm the compound's mechanism of action.
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| Cell Assay |
For in vitro cellular assays, Hordenine hydrochloride is tested in melanocyte cell cultures. Cells are treated with the compound, and melanin production is measured to assess its inhibitory effects. cAMP levels may also be quantified to confirm the mechanism of action.
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| Animal Protocol |
In vivo animal studies for Hordenine hydrochloride have not been extensively documented. Based on its melanogenesis inhibitory properties, potential studies could involve topical or systemic administration to animal models to assess effects on skin pigmentation.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for Hordenine hydrochloride are limited. As a small-molecule alkaloid, it is expected to have moderate oral bioavailability and may undergo metabolism in the liver. Further studies are needed to determine its ADME profile.
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| Toxicity/Toxicokinetics |
Toxicological data for Hordenine hydrochloride are limited. As a naturally occurring alkaloid, it is generally considered to have low toxicity at moderate doses. Comprehensive safety evaluations would be required for therapeutic development. The compound has a molecular weight of 201.70 and a molecular formula of C₁₀H₁₆ClNO.
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| References | |
| Additional Infomation |
Hordenine hydrochloride is an alkaloid found in plants that inhibits melanogenesis by suppressing cAMP production. It is used in research related to melanin production and skin pigmentation. The compound is also known as Ordenina hydrochloride and Peyocactine hydrochloride.
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| Molecular Formula |
C10H16CLNO
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|---|---|
| Exact Mass |
201.092
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| CAS # |
6027-23-2
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| Related CAS # |
539-15-1 (Parent)
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| PubChem CID |
165396
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| Appearance |
White to off-white solid powder
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| Boiling Point |
270.2ºC at 760 mmHg
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| Melting Point |
178 °C
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| Flash Point |
123.5ºC
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| LogP |
2.298
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
13
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| Complexity |
117
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CN(C)CCC1=CC=C(C=C1)O.Cl
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| InChi Key |
KIZRJFIRFPIRFS-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C10H15NO.ClH/c1-11(2)8-7-9-3-5-10(12)6-4-9;/h3-6,12H,7-8H2,1-2H3;1H
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| Chemical Name |
4-[2-(dimethylamino)ethyl]phenol;hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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