| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| ln Vitro |
In stroke, farnesyl pyrophosphate functions as a well-known danger signal that causes immediate cell death and subsequent loss of neurons. With its highly charged pyrophosphate head group and hydrophobic 15-carbon isoprenyl chain, farnesyl pyrophosphate causes abrupt cell death without affecting the cell's downstream metabolic pathways. Mechanistically, the cation channel transient receptor potential melastatin 2 (TRPM2) and extracellular calcium influx are key players in the cell death caused by farnesyl pyrophosphate. TRPM2 is activated by farnesyl pyrophosphate acid, which opens ion inflow [1].
|
|---|---|
| ln Vivo |
Farnesyl pyrophosphate builds up in the brain of a mouse model of middle cerebral artery occlusion (MCAO), suggesting a role for both Farnesyl pyrophosphate and the TRPM2 danger signal axis in ischemia damage. Important functions for the MVA pathway and the Farnesyl pyrophosphate/TRPM2 signaling axis are seen in brain ischemia and possible neurodegenerative disorders [1].
|
| References | |
| Additional Infomation |
2-trans,6-trans-farnesyl diphosphate is the trans,trans-stereoisomer of farnesyl diphosphate. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a 2-trans,6-trans-farnesyl diphosphate(3-).
Farnesyl pyrophosphate is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). Farnesyl diphosphate has been reported in Tripterygium wilfordii, Myxococcus xanthus, and other organisms with data available. Farnesyl pyrophosphate is a metabolite found in or produced by Saccharomyces cerevisiae. 2-trans,6-trans-farnesyl diphosphate is a metabolite found in or produced by Saccharomyces cerevisiae. |
| Molecular Formula |
C15H28O7P2
|
|---|---|
| Molecular Weight |
382.33
|
| Exact Mass |
433.21
|
| CAS # |
13058-04-3
|
| Related CAS # |
Farnesyl Pyrophosphate ammonium
|
| PubChem CID |
445713
|
| Appearance |
Typically exists as solid at room temperature
|
| Flash Point |
16 °C - closed cup (lit.)
|
| LogP |
5.603
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
7
|
| Rotatable Bond Count |
11
|
| Heavy Atom Count |
24
|
| Complexity |
568
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
C/C(=C/CC/C(=C/CC/C(=C/COP(OP(=O)(O)O)(O)=O)/C)/C)/C
|
| InChi Key |
VWFJDQUYCIWHTN-YFVJMOTDSA-N
|
| InChi Code |
InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+
|
| Chemical Name |
phosphono [(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl] hydrogen phosphate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6155 mL | 13.0777 mL | 26.1554 mL | |
| 5 mM | 0.5231 mL | 2.6155 mL | 5.2311 mL | |
| 10 mM | 0.2616 mL | 1.3078 mL | 2.6155 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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