| Size | Price | Stock | Qty |
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| 50g |
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| Other Sizes |
| Targets |
No specific biological target has been identified for 2-amino-6-fluoropyridine, as it functions primarily as a synthetic intermediate rather than a direct pharmacological agent. However, the compound's pyridine core and amino functionality provide a scaffold for the synthesis of molecules that interact with various biological targets. The amino group can form hydrogen bonds and ionic interactions with biological targets, while the pyridine ring can participate in π-π stacking and hydrophobic interactions. The fluorine atom can enhance metabolic stability, modulate lipophilicity, and participate in halogen bonding with biological targets. The compound serves as a precursor for the synthesis of various pyridine-based pharmaceuticals and bioactive molecules. Its derivatives may target diverse biological pathways including enzymes, receptors, and transporters. The compound's small size and polar character may facilitate interactions with biological targets through hydrogen bonding and other non-covalent interactions.
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| ln Vitro |
In vitro, 2-amino-6-fluoropyridine is used as a building block in organic synthesis for the construction of more complex pyridine derivatives. The compound's amino group allows for acylation, alkylation, and other transformations to form amides, sulfonamides, and other derivatives. The fluorine atom can be used to modulate the properties of drug candidates. It is a useful research chemical that may be utilized as a biomaterial or organic/chemical reagent for biomedical research. In medicinal chemistry, the compound serves as a scaffold for the synthesis of pyridine-based drug candidates. Its amino and fluorine substituents allow for the introduction of various functional groups to optimize biological activity and pharmacokinetic properties. In organic synthesis, it is used as a versatile building block for creating complex molecules efficiently.
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| Enzyme Assay |
Cell-free assays for 2-amino-6-fluoropyridine are focused on its use as a chemical reagent. Standard protocols for amide formation involve coupling the compound's amine with carboxylic acids using coupling reagents such as HATU, HOBt, or EDC. The reaction progress is monitored by TLC or HPLC, and the products are purified by column chromatography. The compound's reactivity can be studied using various analytical techniques including NMR spectroscopy, mass spectrometry, and HPLC. Its use as a building block for pharmaceutical synthesis involves standard organic synthesis procedures.
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| Cell Assay |
Cellular assays are not commonly performed with 2-amino-6-fluoropyridine itself, as it is primarily a chemical intermediate rather than a bioactive compound. However, its derivatives may be evaluated in cell-based systems for various biological activities. The parent compound itself is not used as a test article in cell-based experiments due to its primary role as a synthetic building block. Instead, it is used in the synthesis of drug candidates that are subsequently tested in cellular assays.
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| Animal Protocol |
Animal studies are not conducted with the parent compound 2-amino-6-fluoropyridine. Its derivatives may be evaluated in animal models for therapeutic efficacy, but the parent compound itself is not administered to animals. The compound is a synthetic intermediate and is not intended for therapeutic use.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for 2-amino-6-fluoropyridine are not available, as the compound is primarily a chemical reagent rather than a drug candidate. With a molecular weight of 112.11 g/mol and a melting point of 57-61 °C, the compound is small and would be expected to have moderate membrane permeability if administered. However, comprehensive pharmacokinetic studies including absorption, distribution, metabolism, and excretion have not been performed, as the compound is not intended for therapeutic use. For research purposes, the compound is typically handled as a neat chemical and not administered to living organisms for pharmacokinetic profiling.
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| Additional Infomation |
2-Amino-6-fluoropyridine is a research chemical, not an approved drug. It has no clinical trial or marketing approval status for therapeutic use. The compound is a useful research chemical that may be utilized as a biomaterial or organic/chemical reagent for biomedical research. It has a molecular formula of C5H5FN2 and a molecular weight of 112.11 g/mol. It appears as a white to almost white powder or crystal with a melting point of 57-61 °C and a boiling point of 225.0 °C. It has a purity of ≥98.0% by GC and nonaqueous titration.
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| Molecular Formula |
C5H5FN2
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|---|---|
| Molecular Weight |
112.11
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| Exact Mass |
112.043
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| CAS # |
1597-32-6
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| PubChem CID |
2761399
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| Appearance |
Off-white to light brown solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
225.0±20.0 °C at 760 mmHg
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| Melting Point |
59-61ºC
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| Flash Point |
89.9±21.8 °C
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| Vapour Pressure |
0.1±0.4 mmHg at 25°C
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| Index of Refraction |
1.554
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| LogP |
1.13
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
8
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| Complexity |
76.8
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| Defined Atom Stereocenter Count |
0
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| SMILES |
NC1=NC(F)=CC=C1
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| InChi Key |
UZALKVXCOUSWSL-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C5H5FN2/c6-4-2-1-3-5(7)8-4/h1-3H,(H2,7,8)
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| Chemical Name |
6-fluoropyridin-2-amine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.9198 mL | 44.5991 mL | 89.1981 mL | |
| 5 mM | 1.7840 mL | 8.9198 mL | 17.8396 mL | |
| 10 mM | 0.8920 mL | 4.4599 mL | 8.9198 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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