| Size | Price | Stock | Qty |
|---|---|---|---|
| 250g |
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| Other Sizes |
| Targets |
(S)-2-Aminopropanamide hydrochloride does not have a specific primary biological target, as it functions primarily as a synthetic building block rather than a direct pharmacological agent. However, the compound's L-alanineamide moiety is a structural motif found in various biologically active peptides and peptidomimetics. The compound's amide group can form hydrogen bonds with biological targets, while the amino group can participate in ionic interactions. Its defined (S)-stereochemistry is critical for the biological activity of the final peptide-based drug molecules. The compound serves as a precursor for the synthesis of various peptide-based pharmaceuticals, including enzyme inhibitors, receptor agonists, and antimicrobial peptides. Its derivatives may target diverse biological pathways including proteases, receptors, and transporters. The compound's C-terminal amide protection allows for selective incorporation into peptide sequences during solid-phase peptide synthesis.
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|---|---|
| ln Vitro |
In vitro, (S)-2-aminopropanamide hydrochloride is used as a building block in peptide synthesis for the construction of peptide-based drug candidates. It is a highly crystalline, enantiomerically pure C-terminal protected amino acid derivative. In peptide synthesis, the compound is used to introduce L-alanineamide residues into peptide sequences. The compound's amide functionality provides a protected C-terminus that can be deprotected and further functionalized. In medicinal chemistry, it serves as a scaffold for the synthesis of peptide-based drug candidates, particularly enzyme inhibitors and antimicrobial peptides. Its defined (S)-stereochemistry is critical for the biological activity of the final peptide molecules. In organic synthesis, it is used as a versatile building block for creating complex molecules efficiently.
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| Enzyme Assay |
Cell-free assays for (S)-2-aminopropanamide hydrochloride are focused on its use as a chemical reagent. Standard protocols for peptide synthesis involve coupling the compound with amino acids or peptides using coupling reagents such as HATU, HOBt, or EDC. The reaction progress is monitored by HPLC or MS. The compound's reactivity can be studied using various analytical techniques including NMR spectroscopy, mass spectrometry, and HPLC. Its use as a building block for pharmaceutical synthesis involves standard organic synthesis procedures.
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| Cell Assay |
Cellular assays are not performed with the parent compound (S)-2-aminopropanamide hydrochloride. Instead, its derivatives, such as peptide-based drug candidates, are evaluated in cell-based systems for various biological activities. Peptide-based drugs are tested in cell-based assays for receptor binding, enzyme inhibition, antimicrobial activity, or other relevant endpoints. The parent compound itself is not used as a test article in cell-based experiments due to its role as a synthetic building block.
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| Animal Protocol |
Animal studies are not conducted with the parent compound (S)-2-aminopropanamide hydrochloride. Its derivatives, such as peptide-based drug candidates, are evaluated in animal models for therapeutic efficacy. The parent compound itself is not administered to animals, as it is a synthetic intermediate. Toxicity and pharmacological profiles for the parent compound are inferred from related amino acid amide derivatives.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for (S)-2-aminopropanamide hydrochloride are not available, as the compound is primarily a chemical intermediate rather than a drug candidate. With a molecular weight of 124.57 g/mol and a melting point of 222-227 °C, the compound is small and polar, suggesting limited membrane permeability if administered. However, comprehensive pharmacokinetic studies including absorption, distribution, metabolism, and excretion have not been performed, as the compound is not intended for therapeutic use. For research purposes, the compound is typically handled as a neat chemical and not administered to living organisms for pharmacokinetic profiling.
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| Additional Infomation |
(S)-2-Aminopropanamide hydrochloride is a research chemical, not an approved drug. It has no clinical trial or marketing approval status for therapeutic use. The compound is a highly crystalline, enantiomerically pure C-terminal protected amino acid derivative. It is a biochemical reagent that can be used as a biological material or organic compound for life science related research. The compound has a molecular formula of C3H9ClN2O and a molecular weight of 124.57 g/mol. It appears as a solid with a melting point of 222-227 °C and has a purity of ≥95%. It should be stored at room temperature in a cool and dark place, preferably below 15 °C.
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| Molecular Formula |
C3H9CLN2O
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|---|---|
| Molecular Weight |
124.57
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| Exact Mass |
124.04
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| CAS # |
33208-99-0
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| PubChem CID |
2775816
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| Appearance |
White to off-white solid powder
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| Boiling Point |
247.4ºC at 760 mmHg
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| Melting Point |
212-217°C
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| Flash Point |
103.4ºC
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| LogP |
1.021
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
7
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| Complexity |
61.8
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| Defined Atom Stereocenter Count |
1
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| SMILES |
C[C@H](N)C(N)=O.[H]Cl
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| InChi Key |
FIAINKIUSZGVGX-DKWTVANSSA-N
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| InChi Code |
InChI=1S/C3H8N2O.ClH/c1-2(4)3(5)6;/h2H,4H2,1H3,(H2,5,6);1H/t2-;/m0./s1
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| Chemical Name |
(2S)-2-aminopropanamide;hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.0276 mL | 40.1381 mL | 80.2761 mL | |
| 5 mM | 1.6055 mL | 8.0276 mL | 16.0552 mL | |
| 10 mM | 0.8028 mL | 4.0138 mL | 8.0276 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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