| Size | Price | Stock | Qty |
|---|---|---|---|
| 25g |
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| Other Sizes |
| Targets |
Fluorinert FC-40 does not have a defined pharmacological target. It is a chemically inert, non-flammable perfluorinated fluid used primarily for heat management in critical systems and laboratory applications. The compound is also a useful modifier for the design of soft porous polymers and may be utilized as a biomaterial or organic/chemical reagent for biomedical research.
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|---|---|
| ln Vitro |
In vitro, Fluorinert FC-40 is used as a chemically inert, non-flammable cooling fluid for heat management in laboratory applications. It is also a useful modifier for the design of soft porous polymers and may be utilized as a biomaterial or organic/chemical reagent for biomedical research. The compound's perfluorinated nature makes it chemically inert and immiscible with most organic solvents and water.
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| ln Vivo |
In vivo data for Fluorinert FC-40 are limited, as the compound is primarily used as a heat transfer fluid and laboratory reagent. It is not intended for therapeutic administration. The compound's perfluorinated nature results in extremely low biological reactivity and minimal absorption. It has no established in vivo pharmacokinetic or pharmacodynamic profile as a drug.
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| Enzyme Assay |
For in vitro applications, Fluorinert FC-40 is used as a heat transfer fluid in temperature-controlled laboratory equipment. It is also used as a modifier for the design of soft porous polymers. The compound's chemical inertness and thermal stability make it suitable for various laboratory applications where non-reactive, non-flammable fluids are required.
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| Cell Assay |
For in vitro cell-based experiments, Fluorinert FC-40 is not typically used directly in cell culture due to its immiscibility with aqueous media. It may be used in specialized applications such as oxygen delivery systems or as a component in microfluidic devices. The compound is not added directly to cell cultures as a test compound.
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| Animal Protocol |
In vivo animal studies for Fluorinert FC-40 are not conducted for therapeutic purposes. The compound may be used in animal studies as a heat transfer fluid or as a component of specialized equipment. It is not administered to animals as a test compound and has no established in vivo efficacy or safety profile as a drug.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for Fluorinert FC-40 are not available, as the compound is not a drug and is not administered to living organisms. The compound has a molecular weight of 521.07+(671.09), a melting point of -57°C, a boiling point of 155°C, a density of 1.87 g/cm³, and a refractive index of 1.2900. It is chemically inert and non-flammable.
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| Toxicity/Toxicokinetics |
Fluorinert FC-40 is classified with hazard statements: May cause respiratory irritation, causes skin irritation, causes serious eye irritation. The compound should be handled with appropriate laboratory safety precautions including the use of personal protective equipment and working in a well-ventilated area. Specific LD₅₀ values and acute toxicity classifications are available from safety data sheets.
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| Additional Infomation |
Fluorinert FC-40 (Perfluoro-compound FC-40, CAS 51142-49-5) is a research-grade perfluorinated fluid, not an FDA-approved pharmaceutical drug. Its primary applications are as a chemically inert, non-flammable cooling fluid for heat management in critical systems and laboratory applications. The compound is also a useful modifier for the design of soft porous polymers and may be utilized as a biomaterial for biomedical research. No clinical trials or approved indications exist for this compound.
|
| Molecular Formula |
C21F48N2
|
|---|---|
| Molecular Weight |
1192.16
|
| Exact Mass |
1191.93
|
| CAS # |
51142-49-5
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| PubChem CID |
2723673
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| Appearance |
Colorless to light yellow liquid
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| Density |
1.85 g/mL at 25ºC(lit.)
|
| Boiling Point |
158-173ºC
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| Melting Point |
-57ºC
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| Flash Point |
64.1ºC
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| Index of Refraction |
1.29
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| LogP |
15.225
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| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
50
|
| Rotatable Bond Count |
15
|
| Heavy Atom Count |
71
|
| Complexity |
1390
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
FC(C(C(C(N(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)C(F)(F)F)(F)F)(F)F)(F)F)(F)F.FC(C(C(C(N(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F
|
| InChi Key |
QDOIZVITZUBGOQ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C12F27N.C9F21N/c13-1(14,7(25,26)27)4(19,20)10(34,35)40(11(36,37)5(21,22)2(15,16)8(28,29)30)12(38,39)6(23,24)3(17,18)9(31,32)33;10-1(11,5(18,19)20)3(14,15)7(24,25)31(9(28,29)30)8(26,27)4(16,17)2(12,13)6(21,22)23
|
| Chemical Name |
1,1,2,2,3,3,4,4,4-nonafluoro-N,N-bis(1,1,2,2,3,3,4,4,4-nonafluorobutyl)butan-1-amine;1,1,2,2,3,3,4,4,4-nonafluoro-N-(1,1,2,2,3,3,4,4,4-nonafluorobutyl)-N-(trifluoromethyl)butan-1-amine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100 mg/mL (83.88 mM)
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.8388 mL | 4.1941 mL | 8.3881 mL | |
| 5 mM | 0.1678 mL | 0.8388 mL | 1.6776 mL | |
| 10 mM | 0.0839 mL | 0.4194 mL | 0.8388 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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