| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
1H-Imidazole hydrochloride does not have a defined pharmacological target. It is a biochemical reagent used as a ligand, buffer, and catalyst in various applications. Imidazole derivatives are known to have various biological activities, but the hydrochloride salt is primarily used as a reagent rather than a drug substance.
|
|---|---|
| ln Vitro |
1H-Imidazole hydrochloride is a biochemical reagent that can be utilized in life science research as an organic compound or biological material.
In vitro, 1H-Imidazole hydrochloride is used as a ligand, buffer, and catalyst. It plays an important role in drug synthesis and natural compound extraction. The compound is also widely used in certain industrial fields such as plastics, coatings, textiles, and electronic materials manufacturing. It is soluble in water (approximately 500 mg/mL) and methanol (50 mg/mL). |
| ln Vivo |
In vivo data for 1H-Imidazole hydrochloride are not available, as the compound is a biochemical reagent used for in vitro applications. It is not intended for in vivo administration and has no established in vivo pharmacokinetic or pharmacodynamic profile. The compound is not designed for therapeutic use, although it has no direct medical applications.
|
| Enzyme Assay |
For in vitro biochemical assays, 1H-Imidazole hydrochloride is used as a buffer component, ligand, or catalyst. The compound is dissolved in water or methanol at appropriate concentrations. As a buffer, it is effective in the pH range of 6.0-8.0. As a ligand, it can coordinate with metal ions in various catalytic and analytical applications. The compound is hygroscopic and should be stored desiccated.
|
| Cell Assay |
For in vitro cell-based experiments, 1H-Imidazole hydrochloride is not typically used directly in cell culture. It is a biochemical reagent used for the synthesis of compounds or as a buffer in assay development. The compound may be used in the preparation of cell culture media or buffers, but it is not added directly to cells as a test compound.
|
| Animal Protocol |
In vivo animal studies for 1H-Imidazole hydrochloride are not applicable, as the compound is a biochemical reagent used for in vitro applications. No animal studies have been conducted for this compound as a therapeutic agent, and it is not intended for diagnostic or therapeutic use in animals or humans.
|
| ADME/Pharmacokinetics |
Pharmacokinetic data for 1H-Imidazole hydrochloride are not available, as the compound is not a drug and is not administered to living organisms. The compound has a molecular weight of 104.54 g/mol and a melting point of 158-161°C. It is highly soluble in water (approximately 500 mg/mL) and methanol (50 mg/mL). The pH of a solution is 9.0-10.0.
|
| Toxicity/Toxicokinetics |
1H-Imidazole hydrochloride is a research chemical and should be handled with appropriate laboratory safety precautions. As an imidazole salt, it may cause skin and eye irritation. The compound is hygroscopic and should be stored desiccated. Specific LD₅₀ values, acute toxicity classifications, and chronic toxicity data are available from safety data sheets. Standard safety practices include the use of personal protective equipment and working in a fume hood.
|
| Additional Infomation |
1H-Imidazole hydrochloride (Imidazole hydrochloride, CAS 1467-16-9) is a research-grade biochemical reagent, not an FDA-approved pharmaceutical drug. Its primary applications are as a ligand, buffer, and catalyst, with important roles in drug synthesis and natural compound extraction. The compound is also used in industrial applications such as plastics, coatings, textiles, and electronic materials manufacturing. No clinical trials or approved indications exist for this compound.
|
| Molecular Formula |
C3H5CLN2
|
|---|---|
| Molecular Weight |
104.54
|
| Exact Mass |
104.014
|
| CAS # |
1467-16-9
|
| PubChem CID |
10197644
|
| Appearance |
White to off-white solid powder
|
| Melting Point |
158-161 °C(lit.)
|
| LogP |
1.211
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
0
|
| Heavy Atom Count |
6
|
| Complexity |
28.1
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
C1=CN=CN1.Cl
|
| InChi Key |
JDIIGWSSTNUWGK-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C3H4N2.ClH/c1-2-5-3-4-1;/h1-3H,(H,4,5);1H
|
| Chemical Name |
1H-imidazole;hydrochloride
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 9.5657 mL | 47.8286 mL | 95.6572 mL | |
| 5 mM | 1.9131 mL | 9.5657 mL | 19.1314 mL | |
| 10 mM | 0.9566 mL | 4.7829 mL | 9.5657 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
