| Size | Price | Stock | Qty |
|---|---|---|---|
| 50g |
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| Other Sizes |
| Targets |
4,4'-Dimethyl-2,2'-bipyridine does not have a defined pharmacological target. It is a bidentate ligand used in coordination chemistry and as a chemical intermediate. The compound is used for the determination of ferrous and cyanide compounds. As a fragment molecule, it provides a structural basis for the design and screening of novel drug candidates.
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| ln Vitro |
for the purpose of measuring cyanide and ferrous iron. initial ingredients for the production of molecules that generate blue light when stimulated at 450 nm and 43% quantum field.
In vitro, 4,4'-dimethyl-2,2'-bipyridine is used as a chemical intermediate and as a bidentate ligand in coordination chemistry. It is used for the determination of ferrous and cyanide compounds. The compound's electron-donating methyl groups modify the electronic and steric profile of the molecule relative to the unsubstituted parent, making it useful for tuning the properties of metal complexes. |
| ln Vivo |
In vivo activity data for 4,4'-dimethyl-2,2'-bipyridine are not available, as the compound is not intended for in vivo administration. It is a chemical intermediate and ligand used for in vitro applications. The compound is not designed for therapeutic use and has no established in vivo pharmacokinetic or pharmacodynamic profile.
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| Enzyme Assay |
For in vitro chemical synthesis, 4,4'-dimethyl-2,2'-bipyridine is used as a ligand in coordination chemistry and as a chemical intermediate. Standard protocols involve dissolving the compound in an appropriate solvent (e.g., ethanol, acetonitrile) and reacting it with metal salts to form coordination complexes. The compound's bidentate nature allows it to chelate metal ions such as ruthenium, iron, and copper, forming stable complexes used in catalysis and materials science.
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| Cell Assay |
For in vitro cell-based experiments, 4,4'-dimethyl-2,2'-bipyridine is not typically used directly in cell culture. It is a chemical intermediate and ligand used for coordination chemistry and organic synthesis. The compound may be used in the synthesis of metal complexes that are subsequently tested in cell-based assays, but it is not added directly to cell cultures as a test compound.
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| Animal Protocol |
In vivo animal studies for 4,4'-dimethyl-2,2'-bipyridine are not applicable, as the compound is a chemical intermediate and ligand used for in vitro applications. No animal studies have been conducted for this compound as a therapeutic agent, and it is not intended for diagnostic or therapeutic use in animals or humans.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of 4,4'-dimethyl-2,2'-bipyridine are not available, as the compound is not a drug and is not administered to living organisms. The compound has a molecular weight of 184.24 g/mol. As a bipyridine derivative, it is expected to have moderate lipophilicity and may bind to metal ions in biological systems. The compound is primarily used as a reagent rather than as a drug candidate.
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| Toxicity/Toxicokinetics |
4,4'-Dimethyl-2,2'-bipyridine is a research chemical and should be handled with appropriate laboratory safety precautions. As a nitrogen-containing heterocycle, it may cause skin and eye irritation. The compound is for research use only and not for human therapeutic or diagnostic applications. Specific LD₅₀ values, acute toxicity classifications, and chronic toxicity data are not available in the public literature. Standard safety practices include the use of personal protective equipment and working in a fume hood.
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| Additional Infomation |
Structure in the first source
4,4'-Dimethyl-2,2'-bipyridine (dmbpy) (CAS 1134-35-6) is primarily a research-grade chemical intermediate and ligand, not an FDA-approved pharmaceutical drug. Its primary applications are as a bidentate ligand in coordination chemistry, as a chemical intermediate, for the determination of ferrous and cyanide compounds, and as a fragment molecule for drug discovery. No clinical trials or approved therapeutic indications exist for this compound. |
| Molecular Formula |
C12H12N2
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|---|---|
| Molecular Weight |
184.24
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| Exact Mass |
184.1
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| CAS # |
1134-35-6
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| PubChem CID |
14338
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| Appearance |
White to light yellow solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
309.3±37.0 °C at 760 mmHg
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| Melting Point |
169-174 °C(lit.)
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| Flash Point |
116.8±18.1 °C
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| Vapour Pressure |
0.0±0.6 mmHg at 25°C
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| Index of Refraction |
1.566
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| LogP |
2.2
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
14
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| Complexity |
161
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| Defined Atom Stereocenter Count |
0
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| SMILES |
N1C([H])=C([H])C(C([H])([H])[H])=C([H])C=1C1C([H])=C(C([H])([H])[H])C([H])=C([H])N=1
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| InChi Key |
NBPGPQJFYXNFKN-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C12H12N2/c1-9-3-5-13-11(7-9)12-8-10(2)4-6-14-12/h3-8H,1-2H3
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| Chemical Name |
4-methyl-2-(4-methylpyridin-2-yl)pyridine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 10 mg/mL (54.28 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.4277 mL | 27.1385 mL | 54.2770 mL | |
| 5 mM | 1.0855 mL | 5.4277 mL | 10.8554 mL | |
| 10 mM | 0.5428 mL | 2.7139 mL | 5.4277 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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