| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
|
||
| 1g |
|
||
| Other Sizes |
| Targets |
Gold(III) chloride trihydrate does not have a defined pharmacological target. It is a chemical reagent used as a precursor for gold nanoparticles and other gold compounds. Its mechanism of action is chemical: the Au(III) center can be reduced to Au(0) to form gold nanoparticles, or it can participate in various chemical reactions as a Lewis acid catalyst.
|
|---|---|
| ln Vitro |
In vitro, gold(III) chloride trihydrate is used as a precursor for the synthesis of gold nanoparticles and other gold compounds. Gold nanoparticles have applications in biomedical research, including drug delivery, imaging, and biosensing. The compound is also used as a catalyst in organic synthesis.
|
| ln Vivo |
In vivo data for gold(III) chloride trihydrate as a therapeutic agent are not available, as the compound is a precursor used for synthesis. Gold nanoparticles prepared from this compound have been studied in vivo for various biomedical applications, but the precursor itself is not administered.
|
| Enzyme Assay |
For in vitro synthesis of gold nanoparticles, gold(III) chloride trihydrate is used as a gold precursor. Standard protocols involve dissolving the compound in water and reducing it with a reducing agent (e.g., sodium citrate, NaBH₄) in the presence of a stabilizer. The resulting gold nanoparticles are characterized by UV-Vis spectroscopy, TEM, and DLS.
|
| Cell Assay |
For in vitro cell-based experiments, gold(III) chloride trihydrate is not typically used directly in cell culture. It is a precursor used for the synthesis of gold nanoparticles or other gold compounds that are subsequently tested in cell-based assays.
|
| Animal Protocol |
In vivo animal studies using gold(III) chloride trihydrate are conducted on the gold nanoparticles or compounds synthesized from it. For biomedical applications, gold nanoparticles are administered to rodents via intravenous injection, and their biodistribution, toxicity, and therapeutic efficacy are assessed.
|
| ADME/Pharmacokinetics |
Pharmacokinetic properties of gold(III) chloride trihydrate are not available, as the compound is not a drug and is not administered to living organisms. The compound is a solid and should be stored under appropriate conditions.
|
| Toxicity/Toxicokinetics |
Gold(III) chloride trihydrate is a research chemical and should be handled with appropriate laboratory safety precautions. As a gold compound, it may cause skin and eye irritation. The compound is for research use only and not for human therapeutic or diagnostic applications.
|
| References |
|
| Additional Infomation |
Gold(III) chloride trihydrate (CAS 16961-25-4) is primarily a research-grade chemical precursor, not an FDA-approved pharmaceutical drug. Its primary application is as a precursor for the synthesis of gold nanoparticles and other gold compounds for biomedical and catalytic research.
|
| Molecular Formula |
HAUCL4.3H2O
|
|---|---|
| Molecular Weight |
393.83
|
| Exact Mass |
391.881
|
| CAS # |
16961-25-4
|
| Appearance |
Yellow to orange solid powder
|
| LogP |
2.675
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100 mg/mL (253.92 mM)
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5392 mL | 12.6958 mL | 25.3917 mL | |
| 5 mM | 0.5078 mL | 2.5392 mL | 5.0783 mL | |
| 10 mM | 0.2539 mL | 1.2696 mL | 2.5392 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
