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| Other Sizes |
| Targets |
Thioglycolate sodium does not have a specific biological target. It is a reducing agent that breaks disulfide bonds in proteins, including keratin in hair. In microbiology, it is used in thioglycolate media to create reducing conditions for the growth of anaerobic bacteria. In animal models, it is used to induce peritonitis by eliciting an inflammatory response.
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| ln Vitro |
In vitro, thioglycolate sodium is used as a reducing agent to break disulfide bonds in proteins. It is used in cosmetics for hair waving and depilation. In microbiology, it is used in thioglycolate media to create anaerobic conditions for bacterial culture. The compound is not typically tested for direct biological activity in cell-based assays.
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| ln Vivo |
A mouse peritonitis model can be created using sodium thioglycolate in animal modeling.
In vivo, thioglycolate sodium is used to construct peritonitis animal models. Intraperitoneal injection of thioglycolate sodium elicits an inflammatory response, recruiting immune cells to the peritoneal cavity. This model is used to study inflammation and immune cell recruitment. The compound is not a therapeutic agent. |
| Enzyme Assay |
Thioglycolate sodium is not used in cell-free enzyme/receptor binding assays. Its role is as a reducing agent and as a reagent for creating anaerobic conditions in microbiology. It is not used in biochemical assays involving enzymes or receptors.
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| Cell Assay |
Thioglycolate sodium is used in cell culture to create reducing conditions in thioglycolate media for the cultivation of anaerobic bacteria. It is not used in mammalian cell culture assays. The compound is toxic to mammalian cells at high concentrations.
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| Animal Protocol |
In vivo, thioglycolate sodium is administered to rodents via intraperitoneal injection to induce peritonitis. The inflammatory response is characterized by the recruitment of neutrophils and macrophages to the peritoneal cavity. Animals are sacrificed at various time points, and peritoneal exudate cells are collected for analysis. All procedures follow institutional animal care guidelines.
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| ADME/Pharmacokinetics |
Thioglycolate sodium is a chemical reagent and is not subject to pharmacokinetic evaluation as a drug. Its physicochemical properties include a molecular weight of 114.1 g/mol and a molecular formula of C2H3NaO2S. The compound is stable under normal storage conditions. It has a strong odor and is soluble in water. It should be stored in a cool, dry place away from oxidizing agents.
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| Toxicity/Toxicokinetics |
Toxicity Summary
Based on available data, the CIR expert panel concluded that…sodium thioacetate (calculated as thioacetic acid) at concentrations up to 15.2% is safe for use in hair straighteners, perming agents, conditioners, styling products, other non-dyeing hair products, as well as hair dyes and colorants, in this safety assessment. Hairdressers should avoid skin contact and minimize skin contact for consumers. In hair removal products, sodium thioacetate is safe if the formulation ensures no irritation under recommended conditions of use. Specific conditions must be met for the use of sodium thioacetate in cosmetics. Thioglycolate sodium can cause skin irritation and may be absorbed through the skin. It has been evaluated in toxicity studies, with no evidence of systemic toxicity or developmental toxicity at administration sites. Dermal application to rats and mice has been studied in NTP toxicity reports. Standard laboratory safety precautions should be observed, including the use of personal protective equipment (gloves, goggles, lab coat) and adequate ventilation. |
| Additional Infomation |
Sodium thioacetate is a white powder with a slight odor. It is used for cold perming and hair removal. Sodium thioacetate is an organosodium salt with the counterion thioacetate (1-). It is a reducing agent. It contains the thioacetate (1-) ion.
Thioglycolate sodium is not a drug but a multifunctional chemical reagent with applications in cosmetics, pharmaceuticals, and laboratory research. It is a strong reducing agent for disulfides and is used to break down keratin in hair for depilatories and hair waving products. In research, it is used to construct peritonitis animal models and in thioglycolate media for anaerobic bacterial culture. It is not approved for therapeutic use. |
| Molecular Formula |
C2H3NAO2S
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|---|---|
| Molecular Weight |
114.10
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| Exact Mass |
113.975
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| CAS # |
367-51-1
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| Related CAS # |
68-11-1 (Parent)
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| PubChem CID |
23690444
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| Appearance |
White to light brown solid powder
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| Density |
1.311g/cm3
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| Boiling Point |
225.5ºC at 760 mmHg
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| Melting Point |
greater than 572 °F (NTP, 1992)
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| Flash Point |
99.8ºC
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
6
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| Complexity |
46.8
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C(C(=O)[O-])S.[Na+]
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| InChi Key |
GNBVPFITFYNRCN-UHFFFAOYSA-M
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| InChi Code |
InChI=1S/C2H4O2S.Na/c3-2(4)1-5;/h5H,1H2,(H,3,4);/q;+1/p-1
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| Chemical Name |
sodium;2-sulfanylacetate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O: 125 mg/mL (1095.53 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.7642 mL | 43.8212 mL | 87.6424 mL | |
| 5 mM | 1.7528 mL | 8.7642 mL | 17.5285 mL | |
| 10 mM | 0.8764 mL | 4.3821 mL | 8.7642 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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