| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
(+)-1-(1-Naphthyl)ethylamine does not have a specific biological target. Its primary use is as a chiral building block and reagent in organic synthesis. As a chiral amine, it can be used for the resolution of racemic acids and as a ligand or catalyst precursor in asymmetric synthesis. It may also serve as a reference standard for pharmaceutical impurities.
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|---|---|
| ln Vitro |
3886-70-2 | Reference Standard for Cinacalcet Impurity 26
This compound does not have biological in vitro activity in a therapeutic sense. Its "activity" is chemical, serving as a reagent. It is used as a building block in the synthesis of more complex molecules, including potential pharmaceuticals. Its optical purity (min. 98.0 ee%) is critical for its application in chiral synthesis. |
| ln Vivo |
(+)-1-(1-Naphthyl)ethylamine is not used in in vivo studies as a therapeutic agent. It is a research chemical used in synthesis and as a reference standard. It may be used to synthesize compounds that are later tested in animals, but the reagent itself is not administered.
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| Enzyme Assay |
Non-cellular assays are not applicable as this compound is not biologically active. It is used as a chemical reagent and reference standard. For its use as a reference standard in impurity testing, analytical methods such as HPLC are employed. The compound's identity and purity are confirmed by techniques like GC and non-aqueous titration.
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| Cell Assay |
This compound is not used in cell-based assays. Its applications are in synthetic chemistry and analytical chemistry. It can be used as a starting material or intermediate in the synthesis of compounds that may later be tested in cells, but it is not the subject of such experiments. It is stored under refrigerated conditions (0-10°C) and in an inert gas to prevent degradation.
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| Animal Protocol |
In vivo animal experiments do not involve (+)-1-(1-Naphthyl)ethylamine as a test article. It is a research chemical. If used in the synthesis of a drug candidate, that candidate would be subjected to animal testing. The compound itself is not intended for therapeutic use.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties are not applicable as this is not a drug. It is a small, lipophilic molecule (LogP 2.67, MW 171.24) that is sensitive to air and moisture. It is stable when stored properly under inert gas and refrigerated conditions. It is incompatible with acids, oxidizing agents, acid anhydrides, and acyl chlorides.
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| Toxicity/Toxicokinetics |
Toxicological data for (+)-1-(1-Naphthyl)ethylamine is limited as it is a research chemical. It should be handled with standard laboratory precautions. It is an amine and can be a skin and respiratory irritant. It should be handled in a fume hood with appropriate PPE. It is not intended for human or veterinary use.
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| Additional Infomation |
(R)-(+)-1-(1-Naphthyl)ethylamine is a chiral amine used as a building block in organic synthesis and as a reference standard in pharmaceutical analysis. Its optical purity is a key specification for its use in chiral resolution and asymmetric synthesis. It is not a drug and has no clinical trials or approved therapeutic status. Its primary value is as a research chemical for the synthesis of enantiomerically pure compounds.
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| Molecular Formula |
C12H13N
|
|---|---|
| Molecular Weight |
171.24
|
| Exact Mass |
171.104
|
| CAS # |
3886-70-2
|
| PubChem CID |
2724264
|
| Appearance |
Colorless to light yellow liquid（Density：1.064±0.06 g/cm3）
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| Density |
1.1±0.1 g/cm3
|
| Boiling Point |
289.9±0.0 °C at 760 mmHg
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| Flash Point |
144.3±11.5 °C
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| Vapour Pressure |
0.0±0.6 mmHg at 25°C
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| Index of Refraction |
1.630
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| LogP |
2.67
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| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
1
|
| Heavy Atom Count |
13
|
| Complexity |
167
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
N([H])([H])[C@]([H])(C([H])([H])[H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12
|
| InChi Key |
RTCUCQWIICFPOD-SECBINFHSA-N
|
| InChi Code |
InChI=1S/C12H13N/c1-9(13)11-8-4-6-10-5-2-3-7-12(10)11/h2-9H,13H2,1H3/t9-/m1/s1
|
| Chemical Name |
(1R)-1-naphthalen-1-ylethanamine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.8398 mL | 29.1988 mL | 58.3976 mL | |
| 5 mM | 1.1680 mL | 5.8398 mL | 11.6795 mL | |
| 10 mM | 0.5840 mL | 2.9199 mL | 5.8398 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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