| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
This compound does not have a specific therapeutic target. As a glutamic acid derivative, it is a fundamental amino acid. It is used as a nutritional supplement and flavor enhancer. Glutamic acid is a key neurotransmitter and metabolic intermediate.
|
|---|---|
| ln Vitro |
Commercial ergot supplements have been made from amino acids and their derivatives. They affect the release of anabolic hormones, the availability of fuel for activity, the ability to think clearly under pressure, and the prevention of muscular damage brought on by exertion. They are regarded as advantageous synergistic food ingredients [1].
This compound is not a therapeutic agent and does not have direct in vitro activity in a pharmacological sense. Its value is as a chemical building block and nutritional supplement. Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. |
| ln Vivo |
This compound is not used in in vivo studies as a therapeutic agent. It is a research chemical and nutritional supplement. It may be used in animal studies as a source of glutamic acid or as a component of diets.
|
| Enzyme Assay |
In vitro assays for this compound are not typical, as it is a basic amino acid. It can be used as a substrate in enzyme assays for glutaminase or glutamate dehydrogenase. Its primary use is as a building block in peptide synthesis and as a food additive.
|
| Cell Assay |
This compound is not used in standard cell-based assays as a therapeutic agent. Its role is as a research chemical and nutritional supplement. Its molecular weight is 183.59 g/mol, and its molecular formula is C₅H₁₀ClNO₄. It should be stored at room temperature for up to 3 years.
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| Animal Protocol |
In vivo, this compound is not administered as a drug. It is a nutritional supplement and a component of many diets. It may be used in animal studies to investigate glutamatergic signaling or as a dietary component.
|
| ADME/Pharmacokinetics |
Pharmacokinetic properties are not applicable as this is not a drug. It is a small molecule (MW 183.59 g/mol) that is a salt of the amino acid glutamic acid. It is soluble in water and very slightly soluble in alcohol and ether.
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| Toxicity/Toxicokinetics |
The toxicity of this compound is not extensively documented. As a research chemical and food additive, it is generally recognized as safe. It should be handled with standard laboratory precautions. The specific target is Amino Acid Derivatives.
|
| References | |
| Additional Infomation |
Glutamic Acid hydrochloride is the hydrochloride form of glutamic acid, a non-essential amino acid. Glutamic Acid hydrochloride acts as a gastric acidifier, releasing hydrochloric acid into the stomach and thus lowering the stomach's pH level. (National Cancer Institute)
(S)-2-aminopentanedioic acid hydrochloride is the hydrochloride salt of L-glutamic acid. It is used as a flavoring, salt substitute, and as a building block in peptide synthesis. It is a fundamental amino acid and a key metabolic intermediate. It is not a pharmaceutical. |
| Molecular Formula |
C5H10CLNO4
|
|---|---|
| Molecular Weight |
183.59
|
| Exact Mass |
183.029
|
| CAS # |
138-15-8
|
| Related CAS # |
56-86-0 (Parent)
|
| PubChem CID |
2723891
|
| Appearance |
White to off-white solid powder
|
| Density |
1.525
|
| Boiling Point |
333.8ºC at 760 mmHg
|
| Melting Point |
214 °C (dec.)(lit.)
|
| Flash Point |
155.7ºC
|
| Vapour Pressure |
2.55E-05mmHg at 25°C
|
| Index of Refraction |
24 ° (C=6, H2O)
|
| LogP |
0.765
|
| Hydrogen Bond Donor Count |
4
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
11
|
| Complexity |
145
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
C(CC(=O)O)[C@@H](C(=O)O)N.Cl
|
| InChi Key |
RPAJSBKBKSSMLJ-DFWYDOINSA-N
|
| InChi Code |
InChI=1S/C5H9NO4.ClH/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);1H/t3-;/m0./s1
|
| Chemical Name |
(2S)-2-aminopentanedioic acid;hydrochloride
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.4469 mL | 27.2346 mL | 54.4692 mL | |
| 5 mM | 1.0894 mL | 5.4469 mL | 10.8938 mL | |
| 10 mM | 0.5447 mL | 2.7235 mL | 5.4469 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Link: https://clinicaltrials.gov/ct2/show/NCT00000768
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