| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Microbial Metabolite Human Endogenous Metabolite
This compound does not have a specific biological target; it functions as a nutritional supplement and cell culture reagent. As a tyrosine derivative, it is used in dietary supplements and research focusing on mental performance, mood enhancement, and stress reduction. It is also utilized in various pharmaceutical and cosmetic formulations for its antioxidant properties and potential to support skin health and improve the appearance of aging skin. It is integral to protein biosynthesis and metabolic pathways. |
|---|---|
| ln Vitro |
Commercial ergot supplements have been made from amino acids and their derivatives. They affect the release of anabolic hormones, the availability of fuel for activity, the ability to think clearly under pressure, and the prevention of muscular damage brought on by exertion. They are regarded as advantageous synergistic food ingredients [1].
This compound is not a therapeutic agent and does not have established in vitro biological activity in a pharmacological sense. Its value is as a nutritional supplement and cell culture reagent. It is used as a component of cell culture media for the routine culture of cells and for the biomanufacturing of recombinant proteins and monoclonal antibodies. Tyrosine is important for phosphorylation/dephosphorylation and is a precursor of various neurotransmitters and hormones. |
| ln Vivo |
This compound is used in vivo as a nutritional supplement rather than as a therapeutic agent. It is the disodium salt form of L-tyrosine, an essential amino acid, designed to provide enhanced solubility and stability in aqueous solutions for supplementation and cell culture applications. It is integral to protein biosynthesis and metabolic pathways.
|
| Enzyme Assay |
Non-cellular enzyme/receptor binding assays are not applicable to L-Tyrosine disodium salt as it is not a drug. Its use is as a nutritional supplement and cell culture reagent. It can be used as a component of cell culture media for the routine culture of cells and for the biomanufacturing of recombinant proteins and monoclonal antibodies.
|
| Cell Assay |
This compound is used in cell culture as a component of cell culture media. It provides enhanced solubility and stability in aqueous solutions compared to the free amino acid. It is used for the routine culture of cells and for the biomanufacturing of recombinant proteins and monoclonal antibodies. It should be stored under appropriate conditions.
|
| Animal Protocol |
In vivo, this compound is used as a nutritional supplement in animal studies. It may be used to study tyrosine metabolism, neurotransmitter synthesis, or as a dietary supplement in animal models. It is also used in various pharmaceutical and cosmetic formulations.
|
| ADME/Pharmacokinetics |
Pharmacokinetic properties of L-Tyrosine disodium salt are related to its role as a nutritional supplement. It is a small molecule (MW 225.16 g/mol) with the formula C9H9NNa2O3. As the disodium salt, it has enhanced solubility in aqueous solutions compared to the free amino acid. Tyrosine is a precursor of various neurotransmitters and hormones.
|
| Toxicity/Toxicokinetics |
The toxicity of L-Tyrosine disodium salt is not extensively documented, as it is a nutritional supplement and cell culture reagent generally recognized as safe for its intended uses. It should be handled with standard laboratory precautions. The compound is a faint yellow to light brown solid. It is not intended for therapeutic use.
|
| References | |
| Additional Infomation |
L-Tyrosine disodium salt is the disodium salt of L-tyrosine. It contains the L-tyrosine ion (2-).
L-Tyrosine disodium salt is a specialized form of the essential amino acid tyrosine designed to provide enhanced solubility and stability in aqueous solutions. It is used in dietary supplements and research focusing on mental performance, mood enhancement, and stress reduction. It is also utilized in various pharmaceutical and cosmetic formulations for its antioxidant properties. It is integral to protein biosynthesis and metabolic pathways. It is not a pharmaceutical and has no clinical trials or approved therapeutic status. |
| Molecular Formula |
C9H9NNA2O3
|
|---|---|
| Molecular Weight |
225.15
|
| Exact Mass |
225.037
|
| CAS # |
69847-45-6
|
| Related CAS # |
L-Tyrosine;60-18-4;L-Tyrosine-d4;62595-14-6
|
| PubChem CID |
44120124
|
| Appearance |
White to off-white solid powder
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
15
|
| Complexity |
170
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
[Na+].[Na+].O([H])C1C([H])=C([H])C(=C([H])C=1[H])C([H])([H])[C@@]([H])(C(=O)[O-])N([H])[H].O([H])C1C([H])=C([H])C(=C([H])C=1[H])C([H])([H])[C@@]([H])(C(=O)[O-])N([H])[H]
|
| InChi Key |
ASIYFCYUCMQNGK-JZGIKJSDSA-L
|
| InChi Code |
InChI=1S/C9H11NO3.2Na/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;;/h1-4,8,11H,5,10H2,(H,12,13);;/q;2*+1/p-2/t8-;;/m0../s1
|
| Chemical Name |
disodium;(2S)-2-amino-3-(4-oxidophenyl)propanoate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O: 100 mg/mL (444.15 mM)
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.4415 mL | 22.2074 mL | 44.4148 mL | |
| 5 mM | 0.8883 mL | 4.4415 mL | 8.8830 mL | |
| 10 mM | 0.4441 mL | 2.2207 mL | 4.4415 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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