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| Other Sizes |
| Targets |
This compound does not have a specific biological target; it functions as a chemical intermediate and research tool. As an N-alkyl glycine derivative, it is used in studies of amino acid metabolism and enzyme activity. It can also serve as a building block in peptide synthesis. N-Ethylglycine is known for its applications in various scientific research fields, including enzyme kinetics, protein structure studies, and drug metabolism. Amino acids and their derivatives have been commercially used as ergogenic supplements.
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| ln Vitro |
Commercial ergot supplements have been made from amino acids and their derivatives. They affect the release of anabolic hormones, the availability of fuel for activity, the ability to think clearly under pressure, and the prevention of muscular damage brought on by exertion. They are regarded as advantageous synergistic food ingredients [1].
This compound is not a therapeutic agent and does not have established in vitro biological activity in a pharmacological sense. Its value is as a research chemical, metabolite, and intermediate. N-Ethylglycine has been explored as an ergogenic supplement, potentially influencing anabolic hormone secretion, serving as fuel during exercise, enhancing mental performance under stress, and preventing exercise-induced muscle damage. However, the compound itself is primarily used as a research tool rather than as a directly active pharmacological agent. |
| ln Vivo |
N-Ethylglycine is not administered in vivo as a therapeutic agent. It is a research chemical and metabolite. It may be used in animal studies to investigate amino acid metabolism or as a reference standard for drug metabolism studies, but it is not a therapeutic agent itself. It has been explored as an ergogenic supplement, but it is not a registered drug.
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| Enzyme Assay |
In vitro assays for N-Ethylglycine are not typical. It can be used as a substrate or standard in enzyme assays for glycine metabolism or as a reference standard in analytical chemistry. It has a role as a metabolite and can be used to study drug metabolism pathways. It can also be used as a building block in peptide synthesis.
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| Cell Assay |
N-Ethylglycine is not used in standard cell-based assays as a therapeutic agent. Its role is as a research chemical and metabolite. It should be stored at room temperature in a cool and dry place, under inert gas to avoid moisture (hygroscopic). It is a solid at 20°C. Purity is typically ≥98%. The product is for research purposes only and is not intended for human or veterinary use.
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| Animal Protocol |
In vivo, N-Ethylglycine is not administered as a drug. It is a research chemical and metabolite. It may be used in animal studies to investigate amino acid metabolism or as a reference standard for drug metabolism studies, but it is not a therapeutic agent itself. It has been identified in Pogostemon cablin.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties are not applicable to N-Ethylglycine as it is not a drug. It is a small molecule (MW 103.12 g/mol) with the formula C4H9NO2. It is a non-proteinogenic amino acid that naturally occurs as a trace metabolite. It is sparingly soluble in water and slightly soluble in methanol.
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| Toxicity/Toxicokinetics |
The toxicity of N-Ethylglycine is not extensively documented, as it is a research chemical not intended for human or veterinary use. It should be handled with standard laboratory precautions, including the use of appropriate personal protective equipment and working in a well-ventilated area. The compound is a solid at room temperature and should be stored in a cool, dry place under inert gas to avoid moisture (hygroscopic). It is not intended for diagnostic, therapeutic, or other medical applications.
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| References |
[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
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| Additional Infomation |
N-Ethylglycine is an N-alkylglycine, a zwitterion tautomer of N-ethylglycine. It has been reported that N-ethylglycine exists in Pogostemon cablin, and relevant data are available for reference.
N-Ethylglycine is an N-alkylated glycine derivative and a non-proteinogenic amino acid that naturally occurs as a trace metabolite and has been identified in the Murchison meteorite. It is used as an intermediate in organic synthesis and has been explored as an ergogenic supplement. It is known for its applications in various scientific research fields, including enzyme kinetics, protein structure studies, and drug metabolism. This compound is not a pharmaceutical and has no clinical trials or approved therapeutic status. |
| Molecular Formula |
C4H9NO2
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|---|---|
| Molecular Weight |
103.12
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| Exact Mass |
103.063
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| CAS # |
627-01-0
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| PubChem CID |
316542
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| Appearance |
White to off-white solid powder
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| Density |
1.052 g/cm3
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| Boiling Point |
200.5ºC at 760 mmHg
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| Melting Point |
182-186ºC
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| Flash Point |
75.1ºC
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| LogP |
0.071
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
7
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| Complexity |
62.7
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CCNCC(=O)O
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| InChi Key |
YPIGGYHFMKJNKV-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C4H9NO2/c1-2-5-3-4(6)7/h5H,2-3H2,1H3,(H,6,7)
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| Chemical Name |
2-(ethylamino)acetic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 9.6974 mL | 48.4872 mL | 96.9744 mL | |
| 5 mM | 1.9395 mL | 9.6974 mL | 19.3949 mL | |
| 10 mM | 0.9697 mL | 4.8487 mL | 9.6974 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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