| Size | Price | Stock | Qty |
|---|---|---|---|
| 5g |
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| Other Sizes |
| Targets |
As a dipeptide, (S)-2-(2-Aminopropanamido)acetic acid does not have a defined primary drug target. Its role is as a research chemical and a building block in peptide synthesis. The compound may be used to study dipeptide transport, metabolism, and biological activity. It may also serve as a precursor for the synthesis of more complex peptides. However, the compound itself is not known to directly bind to or modulate any specific protein or receptor.
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|---|---|
| ln Vitro |
Commercial ergot supplements have been made from amino acids and their derivatives. They affect the release of anabolic hormones, the availability of fuel for activity, the ability to think clearly under pressure, and the prevention of muscular damage brought on by exertion. They are regarded as advantageous synergistic food ingredients [1].
In vitro activity data for (S)-2-(2-Aminopropanamido)acetic acid is primarily related to its role as a chemical precursor or a research tool. It does not exhibit significant intrinsic pharmacological activity in cell-free or cell-based assays. The compound may be used in vitro to study dipeptide metabolism or as a standard in analytical methods. Amino acid derivatives like this one have been commercially used as ergogenic supplements, where they affect the release of anabolic hormones and fuel availability. However, the specific in vitro activity of this dipeptide has not been extensively characterized. |
| ln Vivo |
There is no reported in vivo activity for (S)-2-(2-Aminopropanamido)acetic acid as a drug substance. The compound is used primarily as a research chemical. It may be used in animal studies to investigate dipeptide metabolism or nutritional effects. However, it is not administered for pharmacological evaluation as a drug candidate. Its role is confined to the laboratory, where it serves as a research tool.
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| Enzyme Assay |
In vitro enzyme assays could be used to study the metabolism of (S)-2-(2-Aminopropanamido)acetic acid. For example, the activity of dipeptidases that cleave the Ala-Gly bond could be measured. In such an assay, the compound is incubated with a tissue homogenate or purified enzyme, and the release of alanine and glycine is monitored using HPLC or amino acid analysis. This approach is standard for studying dipeptide metabolism.
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| Cell Assay |
Cell-based assays for (S)-2-(2-Aminopropanamido)acetic acid could involve studying its transport or metabolism in cultured cells. For example, intestinal epithelial cells could be treated with the compound, and its uptake or hydrolysis could be measured. This assay would help elucidate the mechanisms of dipeptide transport and metabolism in a cellular context.
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| Animal Protocol |
In vivo animal experiments for (S)-2-(2-Aminopropanamido)acetic acid could involve studying its nutritional effects or metabolism. For example, rats could be administered the compound orally or intravenously, and blood levels of alanine, glycine, and the dipeptide could be measured over time. This experiment would provide information on the absorption, distribution, and metabolism of the dipeptide in vivo.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of (S)-2-(2-Aminopropanamido)acetic acid have been studied as a dipeptide. It is absorbed from the gastrointestinal tract via peptide transporters (PEPT1) and hydrolyzed by dipeptidases in the intestinal epithelium and plasma. The resulting amino acids (alanine and glycine) are then distributed throughout the body. The half-life of the dipeptide in plasma is typically short due to rapid hydrolysis.
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| Toxicity/Toxicokinetics |
The toxicity profile of (S)-2-(2-Aminopropanamido)acetic acid is generally considered to be low, as it is a naturally occurring dipeptide composed of two amino acids. It is classified for research use only and is not intended for human or veterinary use. Standard laboratory safety precautions should be followed when handling this compound. Specific toxicological information for this compound is not extensively available.
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| References | |
| Additional Infomation |
Ala-Gly is a dipeptide formed from L-alanyl and glycine residues. It is a metabolite and a zwitterion tautomer of Ala-Gly.
(S)-2-(2-Aminopropanamido)acetic acid (Ala-Gly) is a dipeptide used in life sciences research. It is not a drug and has no approved therapeutic indications or clinical trial history. The compound is commercially available from various chemical suppliers for research purposes only. Its primary applications are in studying dipeptide metabolism, transport, and as a building block for peptide synthesis. |
| Molecular Formula |
C5H10N2O3
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|---|---|
| Molecular Weight |
146.14
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| Exact Mass |
146.069
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| CAS # |
687-69-4
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| Related CAS # |
25765-55-3
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| PubChem CID |
6998029
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| Appearance |
White to off-white solid powder
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| Density |
1.263 g/cm3
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| Boiling Point |
417.4ºC at 760 mmHg
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| Melting Point |
249-255ºC (dec.)
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| Flash Point |
206.2ºC
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| LogP |
-3.7
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
10
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| Complexity |
146
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
C[C@H](N)C(NCC(O)=O)=O
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| InChi Key |
CXISPYVYMQWFLE-VKHMYHEASA-N
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| InChi Code |
InChI=1S/C5H10N2O3/c1-3(6)5(10)7-2-4(8)9/h3H,2,6H2,1H3,(H,7,10)(H,8,9)/t3-/m0/s1
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| Chemical Name |
2-[[(2S)-2-aminopropanoyl]amino]acetic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.8428 mL | 34.2138 mL | 68.4275 mL | |
| 5 mM | 1.3686 mL | 6.8428 mL | 13.6855 mL | |
| 10 mM | 0.6843 mL | 3.4214 mL | 6.8428 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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