| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| Other Sizes |
| Targets |
(+)-Fenchone does not target a specific protein or enzyme as a pharmacological agent. Its utility is based on its chemical properties as a chiral monoterpene ketone, making it valuable as a chiral building block in organic synthesis. The compound may interact with olfactory receptors as a flavor and fragrance compound, but this is not a pharmacological target. As a naturally occurring compound found in fennel, it may have some biological activities, but these are not well-characterized in the context of specific molecular targets.
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| ln Vitro |
One of Fenchone's enantiomers, (+)-Fenchone, is found in several essential oils[1].
The in vitro activity of (+)-fenchone is primarily related to its chemical reactivity as a ketone and its chiral properties. The compound is used as a chiral pool starting material and chiral auxiliary precursor, enabling the synthesis of enantiomerically enriched compounds. Its camphor-like odor makes it valuable in perfumery and as a flavor in foods. No specific pharmacological in vitro activities such as enzyme inhibition or receptor modulation have been well-documented for this compound. |
| ln Vivo |
In vivo, (+)-fenchone is not used as a therapeutic agent. It is a constituent of fennel essential oil and is used as a flavor and fragrance compound. The compound may have some biological effects when consumed as part of food or essential oils, but these are not well-characterized in the context of pharmacological activity.
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| Enzyme Assay |
In vitro assays for (+)-fenchone are not typically performed in the context of enzyme or receptor binding, as the compound is primarily used as a chemical reagent and fragrance ingredient. However, as a chiral compound, it may be used in studies of enantioselective reactions or as a standard for analytical methods.
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| Cell Assay |
For in vitro cellular experiments, (+)-fenchone is not typically used in cell-based assays. The compound is primarily used in organic synthesis and as a flavor/fragrance ingredient.
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| Animal Protocol |
In vivo animal experiments with (+)-fenchone are not commonly performed, as the compound is primarily used as a chemical reagent and fragrance ingredient rather than a therapeutic candidate.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of (+)-fenchone have not been extensively characterized. The compound has a molecular weight of 152.24 g/mol and is a liquid at room temperature. It is slightly soluble in water (1.1 g/L at 25°C) and has a density of 0.945-0.948 g/mL. It should be stored at room temperature in a cool, dark place below 15°C.
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| Toxicity/Toxicokinetics |
Toxicological data for (+)-fenchone has not been systematically evaluated for therapeutic use. As a naturally occurring compound used as a flavor and fragrance ingredient, it is generally considered safe at typical exposure levels. However, standard laboratory safety precautions should be observed when handling this chemical reagent.
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| References | |
| Additional Infomation |
(1S,4R)-Fenone is a fenone with a 1S,4R stereochemical configuration. It is a colorless, oily liquid found in anise oil and used in perfumery and food flavoring. It is the enantiomer of (1R,4S)-Fenone. (+)-Fenone has been reported in artemisia, spruce, and other organisms with available data.
(+)-Fenchone is a naturally occurring bicyclic monoterpene ketone found in fennel essential oil. It is used in perfumery and as a flavor in foods, and is widely utilized as a chiral pool starting material, chiral auxiliary precursor, and specialized solvent. The compound has no clinical or therapeutic applications. |
| Molecular Formula |
C10H16O
|
|---|---|
| Molecular Weight |
152.23
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| Exact Mass |
152.12
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| CAS # |
4695-62-9
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| PubChem CID |
1201521
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| Appearance |
Colorless to light yellow liquid
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
193.5±0.0 °C at 760 mmHg
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| Melting Point |
5-6ºC(lit.)
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| Flash Point |
69.3±10.7 °C
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| Vapour Pressure |
0.5±0.3 mmHg at 25°C
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| Index of Refraction |
1.485
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| LogP |
2.13
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
11
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| Complexity |
217
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| Defined Atom Stereocenter Count |
2
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| SMILES |
CC1(C)[C@@H]2CC[C@@](C)(C2)C1=O
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| InChi Key |
LHXDLQBQYFFVNW-XCBNKYQSSA-N
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| InChi Code |
InChI=1S/C10H16O/c1-9(2)7-4-5-10(3,6-7)8(9)11/h7H,4-6H2,1-3H3/t7-,10+/m1/s1
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| Chemical Name |
(1S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.5690 mL | 32.8450 mL | 65.6901 mL | |
| 5 mM | 1.3138 mL | 6.5690 mL | 13.1380 mL | |
| 10 mM | 0.6569 mL | 3.2845 mL | 6.5690 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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