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| Other Sizes |
| Targets |
Ethyl 2-amino-4-methylthiazole-5-carboxylate does not target a specific protein or enzyme as a pharmacological agent. Its utility is as a chemical building block and synthetic intermediate for the preparation of pharmaceutical compounds rather than as a drug targeting specific molecular targets. The thiazole ring is a common pharmacophore in many bioactive molecules, and this compound provides a versatile scaffold for the synthesis of various thiazole-containing drugs.
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| ln Vitro |
The in vitro activity of Ethyl 2-amino-4-methylthiazole-5-carboxylate is its function as a chemical building block for organic synthesis. The compound is useful for pharmaceutical synthesis and is a versatile building block for the preparation of various thiazole-containing bioactive molecules. The compound's structure, featuring an aminothiazole core with methyl and ethyl carboxylate substituents, provides handles for various chemical transformations.
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| ln Vivo |
No significant in vivo activity has been reported for Ethyl 2-amino-4-methylthiazole-5-carboxylate as a therapeutic agent. The compound is primarily utilized as a chemical building block and research intermediate rather than a pharmacologically active compound. It is not intended for therapeutic use in living organisms.
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| Enzyme Assay |
In vitro assays for Ethyl 2-amino-4-methylthiazole-5-carboxylate are not typically performed in the context of enzyme or receptor binding, as the compound is a chemical building block rather than a drug targeting specific biological targets. The compound is used in organic synthesis reactions where it serves as a precursor for the preparation of more complex molecules.
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| Cell Assay |
For in vitro cellular experiments, Ethyl 2-amino-4-methylthiazole-5-carboxylate is not typically used in cell-based assays. The compound is primarily used as a chemical intermediate in organic synthesis.
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| Animal Protocol |
In vivo animal experiments with Ethyl 2-amino-4-methylthiazole-5-carboxylate are not commonly performed, as the compound is primarily used as a chemical building block rather than a therapeutic candidate.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Ethyl 2-amino-4-methylthiazole-5-carboxylate have not been characterized, as the compound is a research-use chemical intermediate rather than a drug candidate. The compound has a molecular weight of 186.23 g/mol and a melting point of 176.0 to 180.0°C.
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| Toxicity/Toxicokinetics |
Ethyl 2-amino-4-methylthiazole-5-carboxylate is intended for research use only and not for human therapeutic or diagnostic applications. Standard laboratory safety precautions should be observed when handling this chemical reagent.
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| Additional Infomation |
Ethyl 2-amino-4-methylthiazole-5-carboxylate (CAS#: 7210-76-6) is a heterocyclic building block for pharmaceutical synthesis. It belongs to the thiazole family and is characterized by a five-membered ring containing sulfur and nitrogen. The compound has no clinical or therapeutic applications.
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| Molecular Formula |
C7H10N2O2S
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|---|---|
| Molecular Weight |
186.23
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| Exact Mass |
186.046
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| CAS # |
7210-76-6
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| PubChem CID |
343747
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| Appearance |
White to off-white solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
320.4±22.0 °C at 760 mmHg
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| Melting Point |
176-180 °C(lit.)
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| Flash Point |
147.6±22.3 °C
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| Vapour Pressure |
0.0±0.7 mmHg at 25°C
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| Index of Refraction |
1.574
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| LogP |
0.71
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
12
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| Complexity |
177
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| Defined Atom Stereocenter Count |
0
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| SMILES |
S1C(N([H])[H])=NC(C([H])([H])[H])=C1C(=O)OC([H])([H])C([H])([H])[H]
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| InChi Key |
WZHUPCREDVWLKC-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C7H10N2O2S/c1-3-11-6(10)5-4(2)9-7(8)12-5/h3H2,1-2H3,(H2,8,9)
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| Chemical Name |
ethyl 2-amino-4-methyl-1,3-thiazole-5-carboxylate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.3697 mL | 26.8485 mL | 53.6970 mL | |
| 5 mM | 1.0739 mL | 5.3697 mL | 10.7394 mL | |
| 10 mM | 0.5370 mL | 2.6849 mL | 5.3697 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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