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Ethyl acrylate-methyl methacrylate copolymer

Cat No.:V67022 Purity: ≥98%
Ethyl acrylate-methyl methacrylate copolymer could be utilized as pharmaceutical excipients such as sustained-release coating materials, matrix sustained-release tablet binders, and sustained-release agents.
Ethyl acrylate-methyl methacrylate copolymer
Ethyl acrylate-methyl methacrylate copolymer Chemical Structure CAS No.: 9010-88-2
Product category: Biochemical Assay Reagents
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
1g
Other Sizes
Official Supplier of:
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Product Description
Ethyl acrylate-methyl methacrylate copolymer could be utilized as pharmaceutical excipients such as sustained-release coating materials, matrix sustained-release tablet binders, and sustained-release agents. Pharmaceutical excipients or pharmaceutical auxiliaries refer to other chemical substances other than drug ingredients used in the pharmaceutical process. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients can also affect the absorption, distribution, metabolism, and elimination (ADME) processes of concomitant medications.
Ethyl acrylate-methyl methacrylate copolymer (CAS#: 9010-88-2), also known as Neutral methacrylate copolymer, is a fully polymerized copolymer of methyl methacrylate and ethyl acrylate. It is produced using a process of emulsion polymerization and manufactured by redox initiated polymerization of the monomers ethyl acrylate and methyl methacrylate using a free radical donor redox initiator system. The copolymer is comprised of the monomers ethyl acrylate and methyl methacrylate in a molar ratio of 2:1. It typically possesses good adhesion properties, making it suitable for applications in coatings, adhesives, and sealants. The copolymer is characterized by its clarity and gloss and is known for its resistance to UV light and weathering, enhancing its longevity in outdoor applications.
Biological Activity I Assay Protocols (From Reference)
Targets
Ethyl acrylate-methyl methacrylate copolymer does not target a specific protein or enzyme as a pharmacological agent. Its utility is as a polymer for industrial applications rather than as a drug targeting specific molecular targets. The copolymer is used in coatings, adhesives, and sealants due to its physical properties.
ln Vitro
The in vitro activity of Ethyl acrylate-methyl methacrylate copolymer is its function as a polymer material with specific physical properties. The copolymer has good adhesion properties, making it suitable for coatings, adhesives, and sealants. It is characterized by clarity and gloss and is resistant to UV light and weathering.
ln Vivo
No significant in vivo activity has been reported for Ethyl acrylate-methyl methacrylate copolymer as a therapeutic agent. The compound is primarily utilized as an industrial polymer rather than a pharmacologically active compound. It is not intended for therapeutic use in living organisms.
Enzyme Assay
In vitro assays for Ethyl acrylate-methyl methacrylate copolymer are not typically performed in the context of biological activity. The polymer is used in industrial applications where its physical properties are characterized by techniques such as tensile testing, adhesion testing, and thermal analysis.
Cell Assay
For in vitro cellular experiments, Ethyl acrylate-methyl methacrylate copolymer is not typically used in cell-based assays. The polymer is primarily used in industrial applications.
Animal Protocol
In vivo animal experiments with Ethyl acrylate-methyl methacrylate copolymer are not commonly performed, as the compound is primarily used as an industrial polymer rather than a therapeutic candidate.
ADME/Pharmacokinetics
Pharmacokinetic properties of Ethyl acrylate-methyl methacrylate copolymer have not been characterized, as the compound is an industrial polymer rather than a drug candidate. The copolymer has a density of 1.2 g/mL at 25°C and appears as a solid at room temperature.
Toxicity/Toxicokinetics
Ethyl acrylate-methyl methacrylate copolymer is intended for industrial use only and not for human therapeutic or diagnostic applications. Standard laboratory safety precautions should be observed when handling this chemical reagent.
References

[1]. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

Additional Infomation
Ethyl acrylate-methyl methacrylate copolymer (Neutral methacrylate copolymer) (CAS#: 9010-88-2) is a fully polymerized copolymer of methyl methacrylate and ethyl acrylate used in coatings, adhesives, and sealants. It is characterized by good adhesion, clarity, gloss, and UV resistance. The compound has no clinical or therapeutic applications.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
(C5H8O2.C5H8O2)X
Exact Mass
200.105
CAS #
9010-88-2
Related CAS #
113547-51-6;121917-49-5;9010-88-2
PubChem CID
62704
Appearance
Typically exists as solid at room temperature
Density
1.2 g/mL at 25ºC(lit.)
Boiling Point
99.5ºC at 760mmHg
Melting Point
150ºC
Flash Point
15.6ºC
Index of Refraction
n20/D 1.49
LogP
1.471
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
5
Heavy Atom Count
14
Complexity
170
Defined Atom Stereocenter Count
0
InChi Key
XPNLOZNCOBKRNJ-UHFFFAOYSA-N
InChi Code
InChI=1S/2C5H8O2/c1-4(2)5(6)7-3;1-3-5(6)7-4-2/h1H2,2-3H3;3H,1,4H2,2H3
Chemical Name
ethyl prop-2-enoate;methyl 2-methylprop-2-enoate
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
Solubility (In Vivo)
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.

Injection Formulations
(e.g. IP/IV/IM/SC)
Injection Formulation 1: DMSO : Tween 80: Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution 50 μL Tween 80 850 μL Saline)
*Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution.
Injection Formulation 2: DMSO : PEG300Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO 400 μLPEG300 50 μL Tween 80 450 μL Saline)
Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO 900 μL Corn oil)
Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals).
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Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO 900 μL (20% SBE-β-CD in saline)]
*Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.
Injection Formulation 5: 2-Hydroxypropyl-β-cyclodextrin : Saline = 50 : 50 (i.e. 500 μL 2-Hydroxypropyl-β-cyclodextrin 500 μL Saline)
Injection Formulation 6: DMSO : PEG300 : castor oil : Saline = 5 : 10 : 20 : 65 (i.e. 50 μL DMSO 100 μLPEG300 200 μL castor oil 650 μL Saline)
Injection Formulation 7: Ethanol : Cremophor : Saline = 10: 10 : 80 (i.e. 100 μL Ethanol 100 μL Cremophor 800 μL Saline)
Injection Formulation 8: Dissolve in Cremophor/Ethanol (50 : 50), then diluted by Saline
Injection Formulation 9: EtOH : Corn oil = 10 : 90 (i.e. 100 μL EtOH 900 μL Corn oil)
Injection Formulation 10: EtOH : PEG300Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL EtOH 400 μLPEG300 50 μL Tween 80 450 μL Saline)


Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium)
Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose
Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals).
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Oral Formulation 3: Dissolved in PEG400
Oral Formulation 4: Suspend in 0.2% Carboxymethyl cellulose
Oral Formulation 5: Dissolve in 0.25% Tween 80 and 0.5% Carboxymethyl cellulose
Oral Formulation 6: Mixing with food powders


Note: Please be aware that the above formulations are for reference only. InvivoChem strongly recommends customers to read literature methods/protocols carefully before determining which formulation you should use for in vivo studies, as different compounds have different solubility properties and have to be formulated differently.

 (Please use freshly prepared in vivo formulations for optimal results.)
Calculator

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An example of molarity calculation using the molarity calculator is shown below:
What is the mass of compound required to make a 10 mM stock solution in 5 ml of DMSO given that the molecular weight of the compound is 350.26 g/mol?
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  • The answer of 17.513 mg appears in the Mass box. In a similar way, you may calculate the volume and concentration.

Dilution Calculator allows you to calculate how to dilute a stock solution of known concentrations. For example, you may Enter C1, C2 & V2 to calculate V1, as detailed below:

What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=25 μM, V2=25 ml and V1 is the unknown:
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  • The answer of 62.5 μL (0.1 ml) appears in the Volume (Start) box
g/mol

Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:

Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
Instructions to calculate molar mass (molecular weight) of a chemical compound:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
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In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)
Step 2: Enter in vivo formulation (This is only a calculator, not the exact formulation for a specific product. Please contact us first if there is no in vivo formulation in the solubility section.)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
             (2) Be sure to add the solvent(s) in order.

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