| Size | Price | Stock | Qty |
|---|---|---|---|
| 100g |
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| Other Sizes |
| Targets |
2,4-Difluorophenol does not target a specific protein or enzyme as a pharmacological agent. Its utility is as a chemical building block and synthetic intermediate rather than as a drug targeting specific molecular targets. The compound's chemical structure, featuring two fluorine atoms on a phenol ring, makes it a valuable precursor for the synthesis of various pharmaceutical compounds. The presence of fluorine atoms can enhance the metabolic stability and binding affinity of drug molecules synthesized from this building block.
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|---|---|
| ln Vitro |
The in vitro activity of 2,4-Difluorophenol is its function as a chemical building block for organic synthesis. The compound is used for the synthesis of various pharmaceutical compounds, such as antivirulence agents. Its chemical properties, including the presence of the phenolic hydroxyl group and the two fluorine substituents, make it a versatile intermediate for the preparation of more complex molecules. The compound can participate in various chemical reactions including electrophilic aromatic substitution, nucleophilic aromatic substitution, and coupling reactions.
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| ln Vivo |
No significant in vivo activity has been reported for 2,4-Difluorophenol as a therapeutic agent. The compound is primarily utilized as a chemical building block and research intermediate rather than a pharmacologically active compound. It is not intended for therapeutic use in living organisms.
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| Enzyme Assay |
In vitro assays for 2,4-Difluorophenol are not typically performed in the context of enzyme or receptor binding, as the compound is a chemical building block rather than a drug targeting specific biological targets. The compound is used in organic synthesis reactions where it serves as a precursor for the preparation of more complex molecules.
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| Cell Assay |
For in vitro cellular experiments, 2,4-Difluorophenol is not typically used in cell-based assays. The compound is primarily used as a chemical reagent in organic synthesis.
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| Animal Protocol |
In vivo animal experiments with 2,4-Difluorophenol are not commonly performed, as the compound is primarily used as a chemical building block rather than a therapeutic candidate.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of 2,4-Difluorophenol have not been characterized, as the compound is a research-use chemical reagent rather than a drug candidate. The compound has a molecular weight of 130.09 g/mol and is slightly soluble in water. It has a melting point of 22.4°C and a boiling point of 52-53°C at 19 mmHg. It should be stored in a flammables area.
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| Toxicity/Toxicokinetics |
2,4-Difluorophenol is intended for research use only and not for human therapeutic or diagnostic applications. Standard laboratory safety precautions should be observed when handling this chemical reagent, including storage in a flammables area.
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| Additional Infomation |
2,4-Difluorophenol (CAS#: 367-27-1) is an organic building block used for the synthesis of various pharmaceutical compounds, such as antivirulence agents. It is a fluorinated phenol derivative with applications in medicinal chemistry. The compound has no clinical or therapeutic applications.
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| Molecular Formula |
C6H4F2O
|
|---|---|
| Molecular Weight |
130.09
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| Exact Mass |
130.023
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| CAS # |
367-27-1
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| PubChem CID |
123051
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| Appearance |
Colorless to off-white <22.4°C solid powder,>22.4°C liquid
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| Density |
1.4±0.1 g/cm3
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| Boiling Point |
145.7±0.0 °C at 760 mmHg
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| Melting Point |
22.4 °C(lit.)
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| Flash Point |
56.7±0.0 °C
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| Vapour Pressure |
3.8±0.2 mmHg at 25°C
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| Index of Refraction |
1.496
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| LogP |
2.04
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
9
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| Complexity |
97.1
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| Defined Atom Stereocenter Count |
0
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| SMILES |
FC1C([H])=C(C([H])=C([H])C=1O[H])F
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| InChi Key |
NVWVWEWVLBKPSM-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H4F2O/c7-4-1-2-6(9)5(8)3-4/h1-3,9H
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| Chemical Name |
2,4-difluorophenol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.6870 mL | 38.4349 mL | 76.8699 mL | |
| 5 mM | 1.5374 mL | 7.6870 mL | 15.3740 mL | |
| 10 mM | 0.7687 mL | 3.8435 mL | 7.6870 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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