| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| 500mg |
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| 1g |
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| Other Sizes |
| Targets |
As a catalyst precursor, Dichloro(benzene)ruthenium(II) dimer does not target a specific protein or enzyme for pharmacological intervention. Its utility is based on its chemical properties as an organometallic ruthenium complex, which enables it to catalyze various organic transformations such as hydrosilylation and other coupling reactions.
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|---|---|
| ln Vitro |
The in vitro activity of Dichloro(benzene)ruthenium(II) dimer is its function as a catalyst precursor in organic synthesis and drug discovery research. The compound is used as a hydrosilylation catalyst and is widely employed in biochemical experiments. Its ruthenium center can participate in various catalytic cycles, enabling the formation of carbon-carbon and carbon-heteroatom bonds.
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| ln Vivo |
No significant in vivo activity has been reported for Dichloro(benzene)ruthenium(II) dimer as a therapeutic agent. The compound is primarily utilized as a chemical catalyst and research reagent rather than a pharmacologically active compound.
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| Enzyme Assay |
In vitro assays for Dichloro(benzene)ruthenium(II) dimer are not typically performed in the context of enzyme or receptor binding. The compound is used in catalytic reactions where it serves as a precursor to active ruthenium catalysts. Reaction monitoring is typically performed by analytical techniques such as TLC, HPLC, or GC.
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| Cell Assay |
For in vitro cellular experiments, Dichloro(benzene)ruthenium(II) dimer is not typically used in cell-based assays. The compound is primarily used as a catalyst in organic synthesis and drug discovery research.
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| Animal Protocol |
In vivo animal experiments with Dichloro(benzene)ruthenium(II) dimer are not commonly performed, as the compound is primarily used as a chemical catalyst rather than a therapeutic candidate.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Dichloro(benzene)ruthenium(II) dimer have not been characterized, as it is a research-use chemical reagent rather than a drug candidate. The compound has a molecular weight of 500.18 g/mol and should be stored under appropriate conditions. It is an orange powder with a purity of 98.0%.
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| Toxicity/Toxicokinetics |
The compound is intended for research use only and not for human therapeutic or diagnostic applications. Standard laboratory safety precautions should be observed when handling this chemical reagent.
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| Additional Infomation |
Dichloro(benzene)ruthenium(II) dimer is a commonly used ruthenium catalyst precursor widely employed in biochemical experiments and drug synthesis research as a hydrosilylation catalyst. The compound has no clinical or therapeutic applications.
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| Molecular Formula |
C12H12CL4RU2
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|---|---|
| Molecular Weight |
500.18
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| Exact Mass |
499.778
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| CAS # |
37366-09-9
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| PubChem CID |
10962144
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| Appearance |
Brown to reddish brown solid powder
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| Melting Point |
250℃
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| LogP |
6.131
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
0
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
18
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| Complexity |
18.3
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C1=CC=CC=C1.C2=CC=CC=C2.[Ru+2].[Cl-].[Cl-].[Ru+2].[Cl-].[Cl-]
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| InChi Key |
YGXMUPKIEHNBNQ-UHFFFAOYSA-J
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| InChi Code |
InChI=1S/2C6H6.4ClH.2Ru/c2*1-2-4-6-5-3-1;;;;;;/h2*1-6H;4*1H;;/q;;;;;;2*+2/p-4
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| Chemical Name |
benzene;dichlororuthenium
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9993 mL | 9.9964 mL | 19.9928 mL | |
| 5 mM | 0.3999 mL | 1.9993 mL | 3.9986 mL | |
| 10 mM | 0.1999 mL | 0.9996 mL | 1.9993 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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