| Size | Price | Stock | Qty |
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| 1g |
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| 5g |
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| Other Sizes |
| Targets |
Sulfobetaine 10 does not target a specific protein or enzyme for pharmacological intervention. Its utility is as a zwitterionic surfactant for protein solubilization and purification. The compound has both positively and negatively charged groups in its structure, which allows it to maintain a neutral charge in solution and reduces its tendency to denature proteins. It is considered a mild non-denaturing surfactant and is extensively used in protein research.
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| ln Vitro |
A biochemical reagent called sulfobetaine 10 can be utilized in life science research as an organic substance or biological material.
The in vitro activity of Sulfobetaine 10 is its function as a zwitterionic surfactant for protein solubilization. The compound is used for the separation, solubilization, and purification of outer membrane proteins. It is used in 2D electrophoresis at a concentration of 2% (w/v). The surfactant disrupts lipid-lipid and lipid-protein interactions within biological membranes while maintaining the native structure and function of membrane proteins. |
| ln Vivo |
No significant in vivo activity has been reported for Sulfobetaine 10 as a therapeutic agent. The compound is primarily utilized as a biochemical reagent and surfactant for protein research rather than a pharmacologically active compound.
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| Enzyme Assay |
In vitro assays for Sulfobetaine 10 involve its use as a detergent for protein solubilization. The compound is added to membrane preparations or protein samples to extract and solubilize membrane proteins while maintaining their native structure and function.
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| Cell Assay |
For in vitro cellular experiments, Sulfobetaine 10 is not typically used in live cell assays. The compound is used in cell lysis buffers for the extraction of membrane proteins for further analysis by electrophoresis or other biochemical techniques.
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| Animal Protocol |
In vivo animal experiments with Sulfobetaine 10 are not commonly performed, as the compound is primarily used as a biochemical reagent rather than a therapeutic candidate.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Sulfobetaine 10 have not been characterized, as it is a research-use chemical reagent rather than a drug candidate. The compound has a molecular weight of 307.49 g/mol and a LogP of -2.77. It should be stored as a powder at -20°C for up to 3 years.
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| Toxicity/Toxicokinetics |
The compound is intended for research use only and not for human therapeutic or diagnostic applications. Standard laboratory safety precautions should be observed when handling this chemical reagent.
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| Additional Infomation |
Sulfobetaine 10 is a zwitterionic surfactant used for solubilizing membrane proteins in biochemistry and biophysics research. It is a mild, non-denaturing detergent that maintains protein structure and function. The compound has no clinical or therapeutic applications.
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| Molecular Formula |
C15H33NO3S
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|---|---|
| Molecular Weight |
307.49
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| Exact Mass |
307.218
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| CAS # |
15163-36-7
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| PubChem CID |
161111
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| Appearance |
White to off-white solid powder
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| Melting Point |
221-224°C
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| LogP |
-2.77
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
12
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| Heavy Atom Count |
20
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| Complexity |
307
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CCCCCCCCCC[N+](C)(C)CCCS(=O)(=O)[O-]
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| InChi Key |
WKALLSVICJPZTM-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C15H33NO3S/c1-4-5-6-7-8-9-10-11-13-16(2,3)14-12-15-20(17,18)19/h4-15H2,1-3H3
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| Chemical Name |
3-[decyl(dimethyl)azaniumyl]propane-1-sulfonate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2521 mL | 16.2607 mL | 32.5214 mL | |
| 5 mM | 0.6504 mL | 3.2521 mL | 6.5043 mL | |
| 10 mM | 0.3252 mL | 1.6261 mL | 3.2521 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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